Saruparib - 98%, high purity , CAS No.2589531-76-8

  • ≥98%
Item Number
S578989
Grouped product items
SKUSizeAvailabilityPrice Qty
S578989-1mg
1mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$108.90
S578989-5mg
5mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$233.90
S578989-10mg
10mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$474.90
S578989-25mg
25mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$629.90
S578989-50mg
50mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$1,434.90
View related series
Cell Cycle/DNA Damage PARP

Basic Description

SynonymsHY-132167 | saruparib [INN] | Azd 5305 | 2589531-76-8 | SY295016 | 2-Pyridinecarboxamide, 5-(4-((7-ethyl-5,6-dihydro-6-oxo-1,5-naphthyridin-3-yl)methyl)-1-piperazinyl)-N-methyl- | EX-A5234 | MS-26971 | NSC834196 | NSC-834196 | SCHEMBL22912701 | 5-(4-((7-E
Specifications & Purity≥98%
Storage TempStore at -20°C
Shipped InIce chest + Ice pads
Product Description

Saruparib (AZD5305) is a potent, orally active and selective PARP inhibitor and trapper with IC50 values of 3 nM and 1400 nM for PARP1 and PARP2, respectively. Saruparib has anti-proliferative activity and inhibits growth in cells with deficiencies in DNA repair. 

Associated Targets(Human)

KCNH2 Tclin HERG (29587 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PARP1 Tclin Poly [ADP-ribose] polymerase-1 (6206 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
DLD-1 (17511 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PARP2 Tclin Poly [ADP-ribose] polymerase 2 (1185 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PARP3 Tclin Poly [ADP-ribose] polymerase 3 (206 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
TNKS Tchem Tankyrase-1 (1241 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PARP4 Tchem Poly [ADP-ribose] polymerase 4 (71 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
TNKS2 Tchem Tankyrase-2 (1531 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PARP14 Tchem Poly [ADP-ribose] polymerase 14 (380 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
TIPARP Tbio TCDD-inducible poly [ADP-ribose] polymerase (41 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PARP11 Tbio Poly [ADP-ribose] polymerase 11 (83 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PARP10 Tchem Poly [ADP-ribose] polymerase 10 (418 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PARP12 Tchem Poly [ADP-ribose] polymerase 12 (63 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PARP8 Tbio Poly [ADP-ribose] polymerase 8 (85 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PARP16 Tchem Mono [ADP-ribose] polymerase PARP16 (46 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PARP9 Tbio Protein mono-ADP-ribosyltransferase PARP9 (12 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Names and Identifiers

IUPAC Name 5-[4-[(7-ethyl-6-oxo-5H-1,5-naphthyridin-3-yl)methyl]piperazin-1-yl]-N-methylpyridine-2-carboxamide
INCHI InChI=1S/C22H26N6O2/c1-3-16-11-19-20(26-21(16)29)10-15(12-24-19)14-27-6-8-28(9-7-27)17-4-5-18(25-13-17)22(30)23-2/h4-5,10-13H,3,6-9,14H2,1-2H3,(H,23,30)(H,26,29)
InChi Key WQAVGRAETZEADU-UHFFFAOYSA-N
Canonical SMILES CCC1=CC2=C(C=C(C=N2)CN3CCN(CC3)C4=CN=C(C=C4)C(=O)NC)NC1=O
Isomeric SMILES CCC1=CC2=C(C=C(C=N2)CN3CCN(CC3)C4=CN=C(C=C4)C(=O)NC)NC1=O
PubChem CID 155586901
Molecular Weight 406.48

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E2415322Certificate of AnalysisMar 14, 2024 S578989
E2415323Certificate of AnalysisMar 14, 2024 S578989
E2415330Certificate of AnalysisMar 14, 2024 S578989
E2415331Certificate of AnalysisMar 14, 2024 S578989
E2415332Certificate of AnalysisMar 14, 2024 S578989
E2415333Certificate of AnalysisMar 14, 2024 S578989
E2415334Certificate of AnalysisMar 14, 2024 S578989
E2415336Certificate of AnalysisMar 14, 2024 S578989
E2415337Certificate of AnalysisMar 14, 2024 S578989
E2415342Certificate of AnalysisMar 14, 2024 S578989

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