The store will not work correctly when cookies are disabled.
JavaScript seems to be disabled in your browser. For the best experience on our site, be sure to turn on Javascript in your browser.
SB 200646 - 98%, high purity , CAS No.143797-63-1
5-HT2 Selective Inhibitors | Agonists | Antagonists | Modulators
Basic Description Synonyms HY-103129A | 1-(1-methylindol-5-yl)-3-(3-pyridyl)urea | UNII-RT8F72CL8L | CS-0119679 | N-(1-Methyl-1H-indol-5-yl)-N'-3-pyridinylurea | N-(1-METHYL-1H-INDOL-5-YL)-N-3-PYRIDINYLUREA | Urea, N-(1-methyl-1H-indol-5-yl)-N'-3-pyridinyl- | SCHEMBL173735 | SB 200 Specifications & Purity ≥98% Biochemical and Physiological Mechanisms SB 200646 (SB 200646A) is a potent, selective and oral-active antagonist of 5-HT2B/2C over 5-HT2A receptor with 50 fold selectivity. The pKi for rat 5-HT2C receptor, rat 5-HT2B receptor and rat 5-HT2A receptor are 6.9, 7.5 and 5.2, respectively. SB 200646 Storage Temp Store at -20°C Shipped In Ice chest + Ice pads Product Description Information
SB 200646 (SB 200646A) is a potent, selective and oral-active antagonist of5-HT2B/2Cover 5-HT2A receptor with 50 fold selectivity. The pKi for rat 5-HT2C receptor, rat 5-HT2B receptor and rat 5-HT2A receptor are 6.9, 7.5 and 5.2, respectively. SB 200646 has electrophysiological and anxiolytic properties in vivo.
Targets
5-HT2B (rat) (Cell-free assay); 5-HT2C (Rat) (Cell-free assay); 5-HT2A (rat) (Cell-free assay) 7.5(pKi); 6.9(pKi); 5.2(pKi)
Product Properties ALogP 1.871 HBD Count 2 Rotatable Bond 2
Associated Targets(Human) Associated Targets(non-human) Mechanisms of Action Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References
Names and Identifiers IUPAC Name 1-(1-methylindol-5-yl)-3-pyridin-3-ylurea INCHI InChI=1S/C15H14N4O/c1-19-8-6-11-9-12(4-5-14(11)19)17-15(20)18-13-3-2-7-16-10-13/h2-10H,1H3,(H2,17,18,20) InChi Key OJZZJTLBYXHUSJ-UHFFFAOYSA-N Canonical SMILES CN1C=CC2=C1C=CC(=C2)NC(=O)NC3=CN=CC=C3 Isomeric SMILES CN1C=CC2=C1C=CC(=C2)NC(=O)NC3=CN=CC=C3 PubChem CID 126769 Molecular Weight 266.3
Chemical and Physical Properties Solubility Solubility (25°C) In vitro DMSO: 53 mg/mL (199.02 mM); Ethanol: 2 mg/mL (7.51 mM); Water: ˂1 mg/mL DMSO(mg / mL) Max Solubility 53 DMSO(mM) Max Solubility 199.023657529103 Water(mg / mL) Max Solubility ˂1
Safety and Hazards(GHS) Pictogram(s) GHS07 Signal Warning Hazard Statements H315: Causes skin irritation
H319: Causes serious eye irritation
H335: May cause respiratory irritation
H302: Harmful if swallowed
Precautionary Statements P261: Avoid breathing dust/fume/gas/mist/vapors/spray.
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352: IF ON SKIN: wash with plenty of water.
P301+P312: IF SWALLOWED: call a POISON CENTER/doctor/... IF you feel unwell.
Solution Calculators Molarity Calculator Determine the necessary mass, volume, or concentration for preparing a solution.
Dilution Calculator Determine the dilution needed to prepare a stock solution.
Reconstitution Calculator
K2225651
