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SB 200646 - 10mM in DMSO, high purity , CAS No.143797-63-1
5-HT2 Selective Inhibitors | Agonists | Antagonists | Modulators
Basic Description Synonyms 143797-63-1 | SB-200646 | N-(1-Methyl-5-indolyl)-N'-(3-pyridyl)urea | 1-(1-Methyl-1H-indol-5-yl)-3-(pyridin-3-yl)urea | Mip-urea | SB 200646 | N-(1-Methyl-1H-indol-5-yl)-N'-3-pyridinylurea | Tocris-1371 | 1-(1-methylindol-5-yl)-3-pyridin-3-ylurea | RT8F72CL8L | CHEBI:8976 | SB Specifications & Purity 10mM in DMSO Biochemical and Physiological Mechanisms SB 200646 (SB 200646A) is a potent, selective and oral-active antagonist of 5-HT2B/2C over 5-HT2A receptor with 50 fold selectivity. The pKi for rat 5-HT2C receptor, rat 5-HT2B receptor and rat 5-HT2A receptor are 6.9, 7.5 and 5.2, respectively. SB 200646 Storage Temp Store at -80°C Shipped In Ice chest + Ice pads Product Description Information
SB 200646 (SB 200646A) is a potent, selective and oral-active antagonist of5-HT2B/2Cover 5-HT2A receptor with 50 fold selectivity. The pKi for rat 5-HT2C receptor, rat 5-HT2B receptor and rat 5-HT2A receptor are 6.9, 7.5 and 5.2, respectively. SB 200646 has electrophysiological and anxiolytic properties in vivo.
Targets
5-HT2B (rat) (Cell-free assay); 5-HT2C (Rat) (Cell-free assay); 5-HT2A (rat) (Cell-free assay) 7.5(pKi); 6.9(pKi); 5.2(pKi)
Product Properties ALogP 1.871 HBD Count 2 Rotatable Bond 2
Associated Targets(Human) Associated Targets(non-human) Mechanisms of Action Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References
Names and Identifiers IUPAC Name 1-(1-methylindol-5-yl)-3-pyridin-3-ylurea INCHI InChI=1S/C15H14N4O/c1-19-8-6-11-9-12(4-5-14(11)19)17-15(20)18-13-3-2-7-16-10-13/h2-10H,1H3,(H2,17,18,20) InChi Key OJZZJTLBYXHUSJ-UHFFFAOYSA-N Canonical SMILES CN1C=CC2=C1C=CC(=C2)NC(=O)NC3=CN=CC=C3 Isomeric SMILES CN1C=CC2=C1C=CC(=C2)NC(=O)NC3=CN=CC=C3 PubChem CID 126769 Molecular Weight 266.3
Chemical and Physical Properties DMSO(mg / mL) Max Solubility 53 DMSO(mM) Max Solubility 199.023657529103 Water(mg / mL) Max Solubility ˂1
Safety and Hazards(GHS) Pictogram(s) GHS07 Signal Warning Hazard Statements H315: Causes skin irritation
H319: Causes serious eye irritation
H335: May cause respiratory irritation
H302: Harmful if swallowed
Precautionary Statements P261: Avoid breathing dust/fume/gas/mist/vapors/spray.
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352: IF ON SKIN: wash with plenty of water.
P301+P312: IF SWALLOWED: call a POISON CENTER/doctor/... IF you feel unwell.
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