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SB 200646 hydrochloride - 96%, high purity , CAS No.143797-62-0
Selective 5-HT 2C / 2B receptor antagonist
Basic Description Synonyms SB 200646 hydrochloride | SB200646 | SB-200646 HCL | 1-(1-methylindol-5-yl)-3-pyridin-3-ylurea;hydrochloride | D80628 | HY-103129 | SR-01000597751-1 | AKOS024456555 | SCHEMBL2116886 | SR-01000597751 | DTXSID901017649 | SB-200646 hydrochloride | 1-(1-Methy Specifications & Purity ≥96% Biochemical and Physiological Mechanisms Selective 5-HT 2C / 2B receptor antagonist. Prevents ethanol-induced, Ca 2+ -dependent miniature inhibitory postsynaptic currents. Shows anxiolytic effects in vivo. Orally active. Storage Temp Store at 2-8°C,Argon charged Shipped In Wet ice Note Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details. Product Description Store at room temperature.
explanation：
SB-200646A is an orally active, selective antagonist of 5-HT2B/2C over 5-HT2A receptor with pKi of 7.5, 6.9 and 5.2 for 5-HT2B, 5-HT2C and 5-HT2A, respectively. SB-200646A exerts anxiolytic and electrophysiological properties in vivo.
Associated Targets(Human) Associated Targets(non-human) Mechanisms of Action Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References
Names and Identifiers IUPAC Name 1-(1-methylindol-5-yl)-3-pyridin-3-ylurea;hydrochloride INCHI InChI=1S/C15H14N4O.ClH/c1-19-8-6-11-9-12(4-5-14(11)19)17-15(20)18-13-3-2-7-16-10-13;/h2-10H,1H3,(H2,17,18,20);1H InChi Key IGRYPUQJEDJLHC-UHFFFAOYSA-N Canonical SMILES CN1C=CC2=C1C=CC(=C2)NC(=O)NC3=CN=CC=C3.Cl Isomeric SMILES CN1C=CC2=C1C=CC(=C2)NC(=O)NC3=CN=CC=C3.Cl PubChem CID 5311422 Molecular Weight 302.76
Chemical and Physical Properties Solubility Soluble in DMSO to 100 mM Sensitivity Moisture sensitive
Safety and Hazards(GHS) Pictogram(s) GHS07 Signal Warning Hazard Statements H315: Causes skin irritation
H319: Causes serious eye irritation
H335: May cause respiratory irritation
Precautionary Statements P261: Avoid breathing dust/fume/gas/mist/vapors/spray.
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352: IF ON SKIN: wash with plenty of water.
P321: Specific treatment (see ... on this label).
P405: Store locked up.
P501: Dispose of contents/container to ...
P264: Wash hands [and …] thoroughly after handling.
P271: Use only outdoors or in a well-ventilated area.
P304+P340: IF INHALED: Remove person to fresh air and keep comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P362+P364: Take off contaminated clothing and wash it before reuse.
P264+P265: Wash hands [and …] thoroughly after handling. Do not touch eyes.
P337+P317: If eye irritation persists: Get medical help.
P332+P317: If skin irritation occurs: Get medical help.
P319: Get medical help if you feel unwell.
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