SB 204741 - 98%, high purity , CAS No.152239-46-8, Antagonist of 5-HT 2B receptor;Antagonist of 5-HT 2C receptor

Item Number

S275502

• Synonyms: SB 204741|152239-46-8|SB204741|1-(1-methylindol-5-yl)-3-(3-methyl-1,2-thiazol-5-yl)urea|SB-204741|1-(1-methyl-1H-indol-5-yl)-3-(3-methylisothiazol-5-yl)urea|N-(1-methyl-5-indolyl)-N'-(3-methyl-5-isothiazolyl)urea|9VHM49MS42|N-(1-Methyl-1H-5-indolyl)-N'-(3
• Specifications & Purity: Moligand™, ≥98%
• Biochemical and Physiological Mechanisms: Selective 5-HT 2B receptor antagonist. High affinity for 5-HT 2B receptors (pK i = 7.85), some activity at 5-HT 2C receptors (pK i = 5.8).
• Storage Temp: Store at 2-8°C
• Shipped In: Wet ice
• Grade: Moligand™
• Action Type: ANTAGONIST
• Mechanism of action: Antagonist of 5-HT 2B receptor;Antagonist of 5-HT 2C receptor
• Note: Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Product Description

 Product description

SB 204741 is a selective and high affinity 5-HT2B antagonist with a pKi value of 7.1.

Application

SB 204741 has been used as a 5-hydroxytryptamine receptor 2B (Htr2B) antagonist:

to inhibit Htr2b signaling to test its effect on hepatic stellate cell (HSC) activation in three-month-old adult zebrafish

to test its effect on the inhibition of fluoxetine effects in depressive-like behavioral studies in mice

to test its effect in reducing scratching behavior evoked by sertraline in mice