SB 204990 - ≥98%(HPLC), high purity , CAS No.154566-12-8

  • ≥98%(HPLC)
Item Number
S286623
Grouped product items
SKUSizeAvailabilityPrice Qty
S286623-5mg
5mg
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$112.90
S286623-10mg
10mg
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$197.90
S286623-25mg
25mg
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$445.90
S286623-50mg
50mg
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$706.90
S286623-100mg
100mg
Available within 4-8 weeks(?)
Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!
$1,226.90

ATP citrate lyase (ACLY) inhibitor

Basic Description

Synonyms(3R,5S)-rel-5-[6-(2,4-Dichlorophenyl)hexyl]tetrahydro-3-hydroxy-2-oxo-3-furanacetic acid | SB-204990 | 2-[(3S,5R)-5-[6-(2,4-dichlorophenyl)hexyl]-3-hydroxy-2-oxooxolan-3-yl]acetic acid | EX-A6876 | 3-Furanacetic acid, 5-(6-(2,4-dichlorophenyl)hexyl)tetrah
Specifications & Purity≥98%(HPLC)
Biochemical and Physiological MechanismsSB-204990 is a cell-permeable and orally available γ-lactone prodrug of the non-cell-permeable SB-201076 that inhibits human and rat ATP citrate-lyase (Ki =1 μM against human and rat ACL) in a predominantly competitive manner with a small but significant
Storage TempStore at -20°C
Shipped InIce chest + Ice pads

Associated Targets(Human)

ACLY Tclin ATP-citrate synthase (168 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
PC-3 (62116 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SK-OV-3 (52876 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
A549 (127892 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Associated Targets(non-human)

Rattus norvegicus (775804 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Mechanisms of Action

Mechanism of ActionAction Typetarget IDTarget NameTarget TypeTarget OrganismBinding Site NameReferences

Names and Identifiers

IUPAC Name 2-[(3S,5R)-5-[6-(2,4-dichlorophenyl)hexyl]-3-hydroxy-2-oxooxolan-3-yl]acetic acid
INCHI InChI=1S/C18H22Cl2O5/c19-13-8-7-12(15(20)9-13)5-3-1-2-4-6-14-10-18(24,11-16(21)22)17(23)25-14/h7-9,14,24H,1-6,10-11H2,(H,21,22)/t14-,18+/m1/s1
InChi Key YTRNLFYTHYWDAU-KDOFPFPSSA-N
Canonical SMILES C1C(OC(=O)C1(CC(=O)O)O)CCCCCCC2=C(C=C(C=C2)Cl)Cl
Isomeric SMILES C1[C@H](OC(=O)[C@]1(CC(=O)O)O)CCCCCCC2=C(C=C(C=C2)Cl)Cl
PubChem CID 10340264
Molecular Weight 389.27

Certificates

Certificate of Analysis(COA)

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5 results found

Lot NumberCertificate TypeDateItem
K2219122Certificate of AnalysisSep 07, 2022 S286623
K2219130Certificate of AnalysisSep 07, 2022 S286623
K2219131Certificate of AnalysisSep 07, 2022 S286623
K2219132Certificate of AnalysisSep 07, 2022 S286623
K2219133Certificate of AnalysisSep 07, 2022 S286623

Chemical and Physical Properties

SolubilitySolvent:DMSO, Max Conc. mg/mL: 38.93, Max Conc. mM: 100; Solvent:ethanol, Max Conc. mg/mL: 38.93, Max Conc. mM: 100

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Solution Calculators