Determine the necessary mass, volume, or concentration for preparing a solution.
Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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SKU | Size | Availability | Price | Qty |
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S286623-5mg | 5mg | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $112.90 | |
S286623-10mg | 10mg | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $197.90 | |
S286623-25mg | 25mg | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $445.90 | |
S286623-50mg | 50mg | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $706.90 | |
S286623-100mg | 100mg | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $1,226.90 |
ATP citrate lyase (ACLY) inhibitor
Synonyms | (3R,5S)-rel-5-[6-(2,4-Dichlorophenyl)hexyl]tetrahydro-3-hydroxy-2-oxo-3-furanacetic acid | SB-204990 | 2-[(3S,5R)-5-[6-(2,4-dichlorophenyl)hexyl]-3-hydroxy-2-oxooxolan-3-yl]acetic acid | EX-A6876 | 3-Furanacetic acid, 5-(6-(2,4-dichlorophenyl)hexyl)tetrah |
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Specifications & Purity | ≥98%(HPLC) |
Biochemical and Physiological Mechanisms | SB-204990 is a cell-permeable and orally available γ-lactone prodrug of the non-cell-permeable SB-201076 that inhibits human and rat ATP citrate-lyase (Ki =1 μM against human and rat ACL) in a predominantly competitive manner with a small but significant |
Storage Temp | Store at -20°C |
Shipped In | Ice chest + Ice pads |
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Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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IUPAC Name | 2-[(3S,5R)-5-[6-(2,4-dichlorophenyl)hexyl]-3-hydroxy-2-oxooxolan-3-yl]acetic acid |
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INCHI | InChI=1S/C18H22Cl2O5/c19-13-8-7-12(15(20)9-13)5-3-1-2-4-6-14-10-18(24,11-16(21)22)17(23)25-14/h7-9,14,24H,1-6,10-11H2,(H,21,22)/t14-,18+/m1/s1 |
InChi Key | YTRNLFYTHYWDAU-KDOFPFPSSA-N |
Canonical SMILES | C1C(OC(=O)C1(CC(=O)O)O)CCCCCCC2=C(C=C(C=C2)Cl)Cl |
Isomeric SMILES | C1[C@H](OC(=O)[C@]1(CC(=O)O)O)CCCCCCC2=C(C=C(C=C2)Cl)Cl |
PubChem CID | 10340264 |
Molecular Weight | 389.27 |
Enter Lot Number to search for COA:
Find and download the COA for your product by matching the lot number on the packaging.
Lot Number | Certificate Type | Date | Item |
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K2219122 | Certificate of Analysis | Sep 07, 2022 | S286623 |
K2219130 | Certificate of Analysis | Sep 07, 2022 | S286623 |
K2219131 | Certificate of Analysis | Sep 07, 2022 | S286623 |
K2219132 | Certificate of Analysis | Sep 07, 2022 | S286623 |
K2219133 | Certificate of Analysis | Sep 07, 2022 | S286623 |
Solubility | Solvent:DMSO, Max Conc. mg/mL: 38.93, Max Conc. mM: 100; Solvent:ethanol, Max Conc. mg/mL: 38.93, Max Conc. mM: 100 |
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