SB 225002 - 98%, high purity , CAS No.182498-32-4, Antagonist of CXCR2

Item Number
S275393
Grouped product items
SKUSizeAvailabilityPrice Qty
S275393-5mg
5mg
In stock
$53.90
S275393-10mg
10mg
In stock
$75.90
S275393-50mg
50mg
Available within 1-2 weeks(?)
Item is derived from our semi-finished stock and is processed in 1-2 weeks.
$314.90
S275393-100mg
100mg
In stock
$532.90

A selective non-peptide CXCR2 antagonist

Basic Description

SynonymsL000539 | J-011676 | CS-3538 | Q27088712 | SCHEMBL1110610 | NCGC00167841-01 | BRD-K61323504-001-03-2 | N-(2-hydroxy-4-nitrophenyl)-N'-(2-bromophenyl)urea | HMS3648O06 | CCG-268049 | HY-16711 | BDBM50203012 | BCP11852 | HSCI1_000088 | DTXSID20397383 | 1-(2
Specifications & PurityMoligand™, ≥98%
Biochemical and Physiological MechanismsA selective non-peptide CXCR2 antagonist. Inhibits IL-8 binding to CXCR2 (IC 50 = 22 nM).
SourceSynthetic
Storage TempStore at -20°C,Desiccated
Shipped InIce chest + Ice pads
GradeMoligand™
Action TypeANTAGONIST
Mechanism of actionAntagonist of CXCR2
NoteWherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Refer to SDS for further information. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description

Product Describtion:

SB225002, a potent, selective and non-peptide CXCR2 antagonist, inhibits 125I-IL-8 binding to CXCR2 with an IC50 of 22 nM.

Associated Targets(Human)

CXCR2 Tchem C-X-C chemokine receptor type 2 (5 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
CXCR1 Tchem C-X-C chemokine receptor type 1 (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
CXCR2 Tchem Interleukin-8 receptor B (3491 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
CXCR1 Tchem Interleukin-8 receptor A (2256 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
SK-OV-3 (52876 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HepG2 (196354 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
HUVEC (11049 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
MDA-MB-231 (73002 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
TDP1 Tchem Tyrosyl-DNA phosphodiesterase 1 (345557 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
MEN1 Tchem Menin/Histone-lysine N-methyltransferase MLL (48157 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
RUNX1 Tbio Runt-related transcription factor 1/Core-binding factor subunit beta (7867 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Associated Targets(non-human)

Hdac6 Histone deacetylase 6 (222 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
rep Replicase polyprotein 1ab (378 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Mechanisms of Action

Mechanism of ActionAction Typetarget IDTarget NameTarget TypeTarget OrganismBinding Site NameReferences

Names and Identifiers

Pubchem Sid488194611
Pubchem Sid Urlhttps://pubchem.ncbi.nlm.nih.gov/substance/488194611
IUPAC Name 1-(2-bromophenyl)-3-(2-hydroxy-4-nitrophenyl)urea
INCHI InChI=1S/C13H10BrN3O4/c14-9-3-1-2-4-10(9)15-13(19)16-11-6-5-8(17(20)21)7-12(11)18/h1-7,18H,(H2,15,16,19)
InChi Key MQBZVUNNWUIPMK-UHFFFAOYSA-N
Canonical SMILES C1=CC=C(C(=C1)NC(=O)NC2=C(C=C(C=C2)[N+](=O)[O-])O)Br
Isomeric SMILES C1=CC=C(C(=C1)NC(=O)NC2=C(C=C(C=C2)[N+](=O)[O-])O)Br
PubChem CID 3854666
Molecular Weight 352.14

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

Find and download the COA for your product by matching the lot number on the packaging.

8 results found

Lot NumberCertificate TypeDateItem
D23201088Certificate of AnalysisFeb 23, 2024 S275393
D23201089Certificate of AnalysisFeb 23, 2024 S275393
D23201093Certificate of AnalysisFeb 23, 2024 S275393
D23201094Certificate of AnalysisFeb 23, 2024 S275393
D23201092Certificate of AnalysisJan 31, 2024 S275393
D23201097Certificate of AnalysisJan 31, 2024 S275393
D23201104Certificate of AnalysisJan 31, 2024 S275393
D23201095Certificate of AnalysisMar 16, 2023 S275393

Chemical and Physical Properties

SolubilitySoluble in DMSO to 75 mM and in ethanol to 25 mM

Safety and Hazards(GHS)

Pictogram(s) GHS07
Signal Warning
Hazard Statements

H315:Causes skin irritation

H319:Causes serious eye irritation

H335:May cause respiratory irritation

Precautionary Statements

P261:Avoid breathing dust/fume/gas/mist/vapors/spray.

P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing.

P280:Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352:IF ON SKIN: wash with plenty of water.

P321:Specific treatment (see ... on this label).

P405:Store locked up.

P501:Dispose of contents/container to ...

P264:Wash hands [and …] thoroughly after handling.

P271:Use only outdoors or in a well-ventilated area.

P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing.

P403+P233:Store in a well-ventilated place. Keep container tightly closed.

P362+P364:Take off contaminated clothing and wash it before reuse.

P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes.

P337+P317:If eye irritation persists: Get medical help.

P332+P317:If skin irritation occurs: Get medical help.

P319:Get medical help if you feel unwell.

Related Documents

References

1. White JR, Lee JM, Young PR, Hertzberg RP, Jurewicz AJ, Chaikin MA, Widdowson K, Foley JJ, Martin LD, Griswold DE et al..  (1998)  Identification of a potent, selective non-peptide CXCR2 antagonist that inhibits interleukin-8-induced neutrophil migration..  J Biol Chem,  273  (17): (10095-8).  [PMID:9553055] [10.1021/op500134e]

Solution Calculators