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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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S275393-5mg | 5mg | In stock | $53.90 | |
S275393-10mg | 10mg | In stock | $75.90 | |
S275393-50mg | 50mg | Available within 1-2 weeks(?) Item is derived from our semi-finished stock and is processed in 1-2 weeks. | $314.90 | |
S275393-100mg | 100mg | In stock | $532.90 |
A selective non-peptide CXCR2 antagonist
Synonyms | L000539 | J-011676 | CS-3538 | Q27088712 | SCHEMBL1110610 | NCGC00167841-01 | BRD-K61323504-001-03-2 | N-(2-hydroxy-4-nitrophenyl)-N'-(2-bromophenyl)urea | HMS3648O06 | CCG-268049 | HY-16711 | BDBM50203012 | BCP11852 | HSCI1_000088 | DTXSID20397383 | 1-(2 |
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Specifications & Purity | Moligand™, ≥98% |
Biochemical and Physiological Mechanisms | A selective non-peptide CXCR2 antagonist. Inhibits IL-8 binding to CXCR2 (IC 50 = 22 nM). |
Source | Synthetic |
Storage Temp | Store at -20°C,Desiccated |
Shipped In | Ice chest + Ice pads |
Grade | Moligand™ |
Action Type | ANTAGONIST |
Mechanism of action | Antagonist of CXCR2 |
Note | Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Refer to SDS for further information. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details. |
Product Description | Product Describtion: SB225002, a potent, selective and non-peptide CXCR2 antagonist, inhibits 125I-IL-8 binding to CXCR2 with an IC50 of 22 nM. |
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Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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Pubchem Sid | 488194611 |
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Pubchem Sid Url | https://pubchem.ncbi.nlm.nih.gov/substance/488194611 |
IUPAC Name | 1-(2-bromophenyl)-3-(2-hydroxy-4-nitrophenyl)urea |
INCHI | InChI=1S/C13H10BrN3O4/c14-9-3-1-2-4-10(9)15-13(19)16-11-6-5-8(17(20)21)7-12(11)18/h1-7,18H,(H2,15,16,19) |
InChi Key | MQBZVUNNWUIPMK-UHFFFAOYSA-N |
Canonical SMILES | C1=CC=C(C(=C1)NC(=O)NC2=C(C=C(C=C2)[N+](=O)[O-])O)Br |
Isomeric SMILES | C1=CC=C(C(=C1)NC(=O)NC2=C(C=C(C=C2)[N+](=O)[O-])O)Br |
PubChem CID | 3854666 |
Molecular Weight | 352.14 |
PubChem CID | 3854666 |
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ChEMBL Ligand | CHEMBL239767 |
BindingDB Ligand | 50203012 |
CAS Registry No. | 182498-32-4 |
GPCRdb Ligand | SB 225002 |
PubChem SID | 488194611 |
Enter Lot Number to search for COA:
Find and download the COA for your product by matching the lot number on the packaging.
Lot Number | Certificate Type | Date | Item |
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D23201088 | Certificate of Analysis | Feb 23, 2024 | S275393 |
D23201089 | Certificate of Analysis | Feb 23, 2024 | S275393 |
D23201093 | Certificate of Analysis | Feb 23, 2024 | S275393 |
D23201094 | Certificate of Analysis | Feb 23, 2024 | S275393 |
D23201092 | Certificate of Analysis | Jan 31, 2024 | S275393 |
D23201097 | Certificate of Analysis | Jan 31, 2024 | S275393 |
D23201104 | Certificate of Analysis | Jan 31, 2024 | S275393 |
D23201095 | Certificate of Analysis | Mar 16, 2023 | S275393 |
Solubility | Soluble in DMSO to 75 mM and in ethanol to 25 mM |
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Pictogram(s) | GHS07 |
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Signal | Warning |
Hazard Statements | H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation |
Precautionary Statements | P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P271:Use only outdoors or in a well-ventilated area. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P362+P364:Take off contaminated clothing and wash it before reuse. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P337+P317:If eye irritation persists: Get medical help. P332+P317:If skin irritation occurs: Get medical help. P319:Get medical help if you feel unwell. |
1. White JR, Lee JM, Young PR, Hertzberg RP, Jurewicz AJ, Chaikin MA, Widdowson K, Foley JJ, Martin LD, Griswold DE et al.. (1998) Identification of a potent, selective non-peptide CXCR2 antagonist that inhibits interleukin-8-induced neutrophil migration.. J Biol Chem, 273 (17): (10095-8). [PMID:9553055] [10.1021/op500134e] |