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SB-277011 , CAS No.215803-78-4, Antagonist of 5-HT 1D receptor;Antagonist of 5-HT 2B receptor;Antagonist of D 3 receptor

CAS#: 215803-78-4
Formula: C₂₈H₃₀N₄O
Molecular Weight: 438.56
PubChem CID: 5311096

Item Number

S125423

Grouped product items
SKU	Size	Availability	Price	Qty
S125423-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,476.90
S125423-50mg	50mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$3,636.90

View related series

5-HT1D receptor Antagonist (21) 5-HT2B receptor Antagonist (50) D3 receptor Antagonist (33) Dopamine Receptor (230) GPCR/G Protein (3067) Neuronal Signaling (3220) All Research Area

Basic Description

Synonyms	SB-277,011A \| SB-277,011-A \| AKOS025147802 \| CS-5889 \| J-523352 \| N-[4-[2-(6-cyano-3,4-dihydro-1H-isoquinolin-2-yl)ethyl]cyclohexyl]quinoline-4-carboxamide;SB-277011 \| SB277011 \| SB-277011 \| trans-N-[4-[2-(6-cyano-1,2,3,4-tetrahydroisoquinolin-2yl)-ethyl]
Specifications & Purity	Moligand™
Biochemical and Physiological Mechanisms	SB-277011 (SB-277011A) is a Dopamine D3 receptor antagonist
Storage Temp	Store at 2-8°C
Shipped In	Wet ice
Grade	Moligand™
Action Type	ANTAGONIST
Mechanism of action	Antagonist of 5-HT 1D receptor;Antagonist of 5-HT 2B receptor;Antagonist of D 3 receptor

Associated Targets(Human)

DRD3 Tclin D(3) dopamine receptor (14 Activities)

Discover Target: DRD3

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

HTR1D Tclin 5-hydroxytryptamine receptor 1D (1 Activities)

Discover Target: HTR1D

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

HTR2B Tclin 5-hydroxytryptamine receptor 2B (1 Activities)

Discover Target: HTR2B

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

DRD2 Tclin Dopamine D2 receptor (23596 Activities)

Discover Target: DRD2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

HRH1 Tclin Histamine H1 receptor (7573 Activities)

Discover Target: HRH1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

DRD3 Tclin Dopamine D3 receptor (14368 Activities)

Discover Target: DRD3

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

KCNH2 Tclin HERG (29587 Activities)

Discover Target: KCNH2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Names and Identifiers

IUPAC Name	N-[4-[2-(6-cyano-3,4-dihydro-1H-isoquinolin-2-yl)ethyl]cyclohexyl]quinoline-4-carboxamide
INCHI	InChI=1S/C28H30N4O/c29-18-21-5-8-23-19-32(16-13-22(23)17-21)15-12-20-6-9-24(10-7-20)31-28(33)26-11-14-30-27-4-2-1-3-25(26)27/h1-5,8,11,14,17,20,24H,6-7,9-10,12-13,15-16,19H2,(H,31,33)
InChi Key	OLWRVVHPJFLNPW-UHFFFAOYSA-N
Canonical SMILES	C1CC(CCC1CCN2CCC3=C(C2)C=CC(=C3)C#N)NC(=O)C4=CC=NC5=CC=CC=C45
Isomeric SMILES	C1CC(CCC1CCN2CCC3=C(C2)C=CC(=C3)C#N)NC(=O)C4=CC=NC5=CC=CC=C45
PubChem CID	5311096
Molecular Weight	438.56

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SB-277011 , CAS No.215803-78-4, Antagonist of 5-HT 1D receptor;Antagonist of 5-HT 2B receptor;Antagonist of D 3 receptor

Basic Description

Associated Targets(Human)

Associated Targets(non-human)

Mechanisms of Action

Names and Identifiers

Certificates

C of A & Other Certificates(BSE/TSE, COO)

Chemical and Physical Properties

Related Documents

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