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SB 328437 (DMSO solution) , CAS No.247580-43-4, Antagonist of CCR3

  • Moligand™
Item Number
S275358
Grouped product items
SKUSizeAvailabilityPrice Qty
S275358-10mg
10mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$187.90
S275358-50mg
50mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$612.90
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Highly potent selective CCR3 antagonist

View related series
CCR3 Antagonist

Basic Description

SynonymsSB 328437|247580-43-4|SB-328437|L-Phenylalanine, N-(1-naphthalenylcarbonyl)-4-nitro-, methyl ester|CHEMBL33227|methyl (2S)-2-(naphthalene-1-carbonylamino)-3-(4-nitrophenyl)propanoate|methyl (2S)-2-(naphthalene-2-carbonylamino)-3-(4-nitrophenyl)propanoate|
Specifications & PurityMoligand™
Storage TempProtected from light,Store at -20°C,Desiccated
Shipped InIce chest + Ice pads
GradeMoligand™
Action TypeANTAGONIST
Mechanism of actionAntagonist of CCR3
Product Description

Shipped at Room Temperature. Store at -20°C. Store In the Dark. Store under desiccating conditions.

Associated Targets

CCR3 Tchem C-C chemokine receptor type 3 11 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

HDAC6 Tclin Histone deacetylase 6 0 Activities

Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

Names and Identifiers

IUPAC Name methyl (2S)-2-(naphthalene-1-carbonylamino)-3-(4-nitrophenyl)propanoate
INCHI InChI=1S/C21H18N2O5/c1-28-21(25)19(13-14-9-11-16(12-10-14)23(26)27)22-20(24)18-8-4-6-15-5-2-3-7-17(15)18/h2-12,19H,13H2,1H3,(H,22,24)/t19-/m0/s1
InChi Key VMFGCGRAIBLAFY-IBGZPJMESA-N
Canonical SMILES COC(=O)C(CC1=CC=C(C=C1)[N+](=O)[O-])NC(=O)C2=CC=CC3=CC=CC=C32
Isomeric SMILES COC(=O)[C@H](CC1=CC=C(C=C1)[N+](=O)[O-])NC(=O)C2=CC=CC3=CC=CC=C32
PubChem CID 10474776
Molecular Weight 378.38

Certificates

Certificate of Analysis(COA)

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Safety and Hazards(GHS)

Pictogram(s) GHS09,   GHS07
Signal Warning
Hazard Statements

H302:Harmful if swallowed

H400:Very toxic to aquatic life

Precautionary Statements

P273:Avoid release to the environment.

P501:Dispose of contents/container to ...

P264:Wash hands [and …] thoroughly after handling.

P270:Do not eat, drink or smoke when using this product.

P391:Collect spillage.

P330:Rinse mouth.

P301+P317:IF SWALLOWED: Get medical help.

Related Documents

 SDS

 Specification Sheet

References

1. Abonyo BO et al..  (2005)  Autoregulation of CCL26 synthesis and secretion in A549 cells: a possible mechanism by which alveolar epithelial cells modulate airway inflammation..  Am J Physiol Lung Cell Mol Physiol,  289  (3): (L478-88).  [PMID:15863444]
2. White JR et al..  (2000)  Identification of potent, selective non-peptide CC chemokine receptor-3 antagonist that inhibits eotaxin-, eotaxin-2-, and monocyte chemotactic protein-4-induced eosinophil migration..  J Biol Chem,  275  (47): (36626-31).  [PMID:10969084]
3. Mori A et al..  (2007)  Selective suppression of Th2-mediated airway eosinophil infiltration by low-molecular weight CCR3 antagonists..  Int Immunol,  19  (8): (913-21).  [PMID:17804691]

Solution Calculators

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