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SB 328437 (DMSO solution) , CAS No.247580-43-4, Antagonist of CCR3

CAS#: 247580-43-4
Formula: C₂₁H₁₈N₂O₅
Molecular Weight: 378.38
PubChem CID: 10474776

Item Number

S275358

Grouped product items
SKU	Size	Availability	Price	Qty
S275358-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$187.90
S275358-50mg	50mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$612.90

Highly potent selective CCR3 antagonist

View related series

CCR CCR3 Antagonist GPCR/G Protein Immunology/Inflammation

Basic Description

Synonyms	F81757 \| AKOS040745353 \| HMS3414E05 \| SCHEMBL3930225 \| MS-26166 \| SB 328437 \| L-Phenylalanine, N-(1-naphthalenylcarbonyl)-4-nitro-, methyl ester \| BDBM50100021 \| DTXSID30440571 \| N-(1-NAPHTHALENYLCARBONYL)-4-NITRO-L-PHENYLALANINE METHYL ESTER \| methyl (2S
Specifications & Purity	Moligand™
Storage Temp	Protected from light,Store at -20°C,Desiccated
Shipped In	Ice chest + Ice pads
Grade	Moligand™
Action Type	ANTAGONIST
Mechanism of action	Antagonist of CCR3
Product Description	Shipped at Room Temperature. Store at -20°C. Store In the Dark. Store under desiccating conditions.

Associated Targets(Human)

CCR3 Tchem C-C chemokine receptor type 3 (11 Activities)

Discover Target: CCR3

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CCR3 Tchem C-C chemokine receptor type 3 (1666 Activities)

Discover Target: CCR3

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Homo sapiens (32628 Activities)

Explore this target

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Associated Targets(non-human)

Hdac6 Histone deacetylase 6 (222 Activities)

Discover Target: Hdac6

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

rep Replicase polyprotein 1ab (378 Activities)

Discover Target: rep

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Names and Identifiers

IUPAC Name	methyl (2S)-2-(naphthalene-1-carbonylamino)-3-(4-nitrophenyl)propanoate
INCHI	InChI=1S/C21H18N2O5/c1-28-21(25)19(13-14-9-11-16(12-10-14)23(26)27)22-20(24)18-8-4-6-15-5-2-3-7-17(15)18/h2-12,19H,13H2,1H3,(H,22,24)/t19-/m0/s1
InChi Key	VMFGCGRAIBLAFY-IBGZPJMESA-N
Canonical SMILES	COC(=O)C(CC1=CC=C(C=C1)[N+](=O)[O-])NC(=O)C2=CC=CC3=CC=CC=C32
Isomeric SMILES	COC(=O)[C@H](CC1=CC=C(C=C1)[N+](=O)[O-])NC(=O)C2=CC=CC3=CC=CC=C32
PubChem CID	10474776
Molecular Weight	378.38

CAS Registry No.

247580-43-4

PubChem CID

5311092

GPCRdb Ligand

SB328437

Safety and Hazards(GHS)

Pictogram(s)	GHS09, GHS07
Signal	Warning
Hazard Statements	H302:Harmful if swallowed H400:Very toxic to aquatic life
Precautionary Statements	P273:Avoid release to the environment. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P270:Do not eat, drink or smoke when using this product. P391:Collect spillage. P330:Rinse mouth. P301+P317:IF SWALLOWED: Get medical help.

References

1. Abonyo BO et al.. (2005) Autoregulation of CCL26 synthesis and secretion in A549 cells: a possible mechanism by which alveolar epithelial cells modulate airway inflammation.. Am J Physiol Lung Cell Mol Physiol, 289 (3): (L478-88). [PMID:15863444]
2. White JR et al.. (2000) Identification of potent, selective non-peptide CC chemokine receptor-3 antagonist that inhibits eotaxin-, eotaxin-2-, and monocyte chemotactic protein-4-induced eosinophil migration.. J Biol Chem, 275 (47): (36626-31). [PMID:10969084]
3. Mori A et al.. (2007) Selective suppression of Th2-mediated airway eosinophil infiltration by low-molecular weight CCR3 antagonists.. Int Immunol, 19 (8): (913-21). [PMID:17804691]

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SB 328437 (DMSO solution) , CAS No.247580-43-4, Antagonist of CCR3

Basic Description

Associated Targets(Human)

Associated Targets(non-human)

Mechanisms of Action

Names and Identifiers

Database links

Certificates

Certificate of Analysis(COA)

Safety and Hazards(GHS)

Related Documents

References

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