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SB 334867 - 10mM in DMSO, high purity , CAS No.792173-99-0
Selective OX 1 receptor antagonist
Basic Description
| Synonyms | 792173-99-0 | 1-(2-methylbenzo[d]oxazol-6-yl)-3-(1,5-naphthyridin-4-yl)urea | 249889-64-3 | SB-334867 | SB-334867 free base | SB 334867 | SB334867 | SB-334867 (free base) | 1-(2-methyl-1,3-benzoxazol-6-yl)-3-(1,5-naphthyridin-4-yl)urea | C17H13N5O2 | SB334867A free base | N-(2 |
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| Specifications & Purity | Moligand™, 10mM in DMSO |
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| Biochemical and Physiological Mechanisms | Selective OX 1 receptor antagonist. Inhibits orexin-A induced intracellular calcium release (IC 50 = 226 nM). Shows anxiolytic, sedative and anorectic effects in vivo. |
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| Storage Temp | Store at -80°C |
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| Shipped In | Ice chest + Ice pads |
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| Grade | Moligand™ |
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Associated Targets(Human)
Associated Targets(non-human)
Names and Identifiers
| IUPAC Name | 1-(2-methyl-1,3-benzoxazol-6-yl)-3-(1,5-naphthyridin-4-yl)urea |
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| INCHI | InChI=1S/C17H13N5O2/c1-10-20-12-5-4-11(9-15(12)24-10)21-17(23)22-14-6-8-18-13-3-2-7-19-16(13)14/h2-9H,1H3,(H2,18,21,22,23) |
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| InChi Key | AKMNUCBQGHFICM-UHFFFAOYSA-N |
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| Canonical SMILES | CC1=NC2=C(O1)C=C(C=C2)NC(=O)NC3=C4C(=NC=C3)C=CC=N4 |
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| Isomeric SMILES | CC1=NC2=C(O1)C=C(C=C2)NC(=O)NC3=C4C(=NC=C3)C=CC=N4 |
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| PubChem CID | 6604926 |
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| Molecular Weight | 319.32 |
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Safety and Hazards(GHS)
| Pictogram(s) | GHS07 |
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| Signal | Warning |
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| Hazard Statements | H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation |
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| Precautionary Statements | P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P271:Use only outdoors or in a well-ventilated area. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P362+P364:Take off contaminated clothing and wash it before reuse. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P337+P317:If eye irritation persists: Get medical help. P332+P317:If skin irritation occurs: Get medical help. P319:Get medical help if you feel unwell. |
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