Potent, competitive and non-selective MMP-2 and MMP-9 inhibitor (K i values are 13.9 and 600 nM for MMP-2 and MMP-9 respectively). Does not alter the activity of MMP-1, MMP-3 or MMP-7 (K i values are 206 (MMP-1), 15 (MMP-3) and 96 (MMP-7) μM).
Storage Temp
Store at -20°C,Desiccated
Shipped In
Ice chest + Ice pads
Grade
Moligand™
Action Type
INHIBITOR
Mechanism of action
Inhibitor of MMP2;Inhibitor of MMP9
Note
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
1.Rai D et al.. (2014) Cerebrospinal fluid cytokines and matrix metalloproteinases in human immunodeficiency seropositive and seronegative patients of tuberculous meningitis.. Ann Indian Acad Neurol, 17 (2):(171-8). [PMID:25024567]
2.Kumar S et al.. (2018) MMP Secretion Rate and Inter-invadopodia Spacing Collectively Govern Cancer Invasiveness.. Biophys J, 114 (3):(650-662). [PMID:29414711]
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I2202895