Basic Description

Synonyms	447410-57-3 \| SB-756050 \| SB756050 \| 1,4-bis((3,4-dimethoxyphenyl)sulfonyl)-1,4-diazepane \| SB-050 \| F3EST236LD \| 1,4-bis[(3,4-dimethoxyphenyl)sulfonyl]-1,4-diazepane \| 1H-1,4-Diazepine, 1,4-bis((3,4-dimethoxyphenyl)sulfonyl)hexahydro- \| ChemDiv1_023869 \| UNII-F3EST236LD \| O
Specifications & Purity	10mM in DMSO
Biochemical and Physiological Mechanisms	SB-756050 is a selective TGR5 agonist (EC50 = 1.3 μM for the human receptor).
Storage Temp	Store at -80°C
Shipped In	Ice chest + Ice pads
Product Description	Information SB-756050 SB-756050 is a selective TGR5 agonist (EC50 = 1.3 μM for the human receptor). Targets TGR5

Product Properties

ALogP	1.527
Rotatable Bond	8

GPBAR1 Tchem G-protein coupled bile acid receptor 1 (1723 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Hdac6 Histone deacetylase 6 (222 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

rep Replicase polyprotein 1ab (378 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

IUPAC Name	1,4-bis[(3,4-dimethoxyphenyl)sulfonyl]-1,4-diazepane
INCHI	InChI=1S/C21H28N2O8S2/c1-28-18-8-6-16(14-20(18)30-3)32(24,25)22-10-5-11-23(13-12-22)33(26,27)17-7-9-19(29-2)21(15-17)31-4/h6-9,14-15H,5,10-13H2,1-4H3
InChi Key	GJUFPAZNBPFNRI-UHFFFAOYSA-N
Canonical SMILES	COC1=C(C=C(C=C1)S(=O)(=O)N2CCCN(CC2)S(=O)(=O)C3=CC(=C(C=C3)OC)OC)OC
Isomeric SMILES	COC1=C(C=C(C=C1)S(=O)(=O)N2CCCN(CC2)S(=O)(=O)C3=CC(=C(C=C3)OC)OC)OC
PubChem CID	1520267
Molecular Weight	500.59

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Pictogram(s)	GHS07
Signal	Warning
Hazard Statements	H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation H302:Harmful if swallowed
Precautionary Statements	P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P271:Use only outdoors or in a well-ventilated area. P362:Take off contaminated clothing. P270:Do not eat, drink or smoke when using this product. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P337+P313:IF eye irritation persists: Get medical advice/attention. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P332+P313:IF SKIN irritation occurs: Get medical advice/attention. P330:Rinse mouth. P301+P312:IF SWALLOWED: call a POISON CENTER/doctor/... IF you feel unwell.

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