SB216763 - ≥98%, high purity , CAS No.280744-09-4, Inhibitor of glycogen synthase kinase 3 alpha;Inhibitor of glycogen synthase kinase 3 beta

Item Number

S129716

• Synonyms: FT-0688716 | B5716 | CHEBI:91421 | GTPL8015 | Lopac-S-3442 | Q4918914 | Z2065671802 | 3-(2,4-dichlorophenyl)-4-(1-methylindol-3-yl)pyrrole-2,5-dione;SB-216763 | C19H12Cl2N2O2 | CCG-101287 | SDCCGSBI-0050908.P002 | NCGC00015949-01 | NCGC00025232-02 | LP009
• Specifications & Purity: Moligand™, ≥98%
• Biochemical and Physiological Mechanisms: SB 216763 is potent and selective glycogen synthase kinase-3 (GSK-3) inhibitor (Ki = 9 nM for GSK-3α); competes with ATP. SB 216763 has minimal activity against 24 other protein kinases (IC50 > 10 μ M). Stimulates glycogen synthesis, gene tran
• Legal Information: Sold for only research purposes
• Storage Temp: Store at -20°C
• Shipped In: Ice chest + Ice pads
• Grade: Moligand™
• Action Type: INHIBITOR
• Mechanism of action: Inhibitor of glycogen synthase kinase 3 alpha;Inhibitor of glycogen synthase kinase 3 beta
• Note: Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Product Description

SB 216763
SB-216763 was used to inhibit GSK-3β in human brain microvascular endothelial cell line⁶and colorectal cancer cells.⁷

^{SB-216763 was used to inhibit GSK-3β in human brain microvascular endothelial cell line and colorectal cancer cells.}