Determine the necessary mass, volume, or concentration for preparing a solution.
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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S125924-10mg | 10mg | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $94.90 | |
S125924-50mg | 50mg | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $355.90 | |
S125924-100mg | 100mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $664.90 |
ALK inhibitor
Synonyms | 4-(4-(benzo[d][1,3]dioxol-5-yl)-5-(pyridin-2-yl)-1H-imidazol-2-yl)benzamide | 4-[4-(1,3-BENZODIOXOL-5-YL)-5-(2-PYRIDINYL)-1H-IMIDAZOL-2-YL]BENZAMIDE | SB431542 | SB-431542 | 4-[4-(1,3-benzodioxol-5-yl)-5-pyridin-2-yl-1H-imidazol-2-yl]benzamide | SB 431542 |
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Specifications & Purity | Moligand™, ≥98% |
Biochemical and Physiological Mechanisms | SB 431542 is a small molecule that acts as a specific and selective inhibitor of TGFβ RI, ACTR-IB and ACTR-IC (transforming growth factor-β superfamily type I activin receptor-like kinase (ALK) receptors ALK4, 5, and 7). Renal carcinoma studies have demon |
Storage Temp | Protected from light,Store at -20°C |
Shipped In | Ice chest + Ice pads |
Grade | Moligand™ |
Action Type | INHIBITOR |
Mechanism of action | Inhibitor of activin A receptor type 1C;Inhibitor of transforming growth factor beta receptor 1 |
Note | Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details. |
Product Description | SB431542 is a potent and selective inhibitor of ALK5 with IC50 of 94 nM in a cell-free assay, 100-fold more selective for ALK5 than p38 MAPK and other kinases. |
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Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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IUPAC Name | 4-[4-(1,3-benzodioxol-5-yl)-5-pyridin-2-yl-1H-imidazol-2-yl]benzamide |
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INCHI | InChI=1S/C22H16N4O3/c23-21(27)13-4-6-14(7-5-13)22-25-19(20(26-22)16-3-1-2-10-24-16)15-8-9-17-18(11-15)29-12-28-17/h1-11H,12H2,(H2,23,27)(H,25,26) |
InChi Key | FHYUGAJXYORMHI-UHFFFAOYSA-N |
Canonical SMILES | C1OC2=C(O1)C=C(C=C2)C3=C(NC(=N3)C4=CC=C(C=C4)C(=O)N)C5=CC=CC=N5 |
Isomeric SMILES | C1OC2=C(O1)C=C(C=C2)C3=C(NC(=N3)C4=CC=C(C=C4)C(=O)N)C5=CC=CC=N5 |
PubChem CID | 4521392 |
Molecular Weight | 384.39 |
ChEMBL Ligand | CHEMBL440084 |
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PubChem CID | 4521392 |
CAS Registry No. | 301836-41-9 |
Wikipedia | SB-431542 |
RCSB PDB Ligand | 85, 085 |
Enter Lot Number to search for COA:
Find and download the COA for your product by matching the lot number on the packaging.
Lot Number | Certificate Type | Date | Item |
---|---|---|---|
G2430449 | Certificate of Analysis | Jul 16, 2024 | S125924 |
G2430450 | Certificate of Analysis | Jul 16, 2024 | S125924 |
G2430451 | Certificate of Analysis | Jul 16, 2024 | S125924 |
G2430476 | Certificate of Analysis | Jul 16, 2024 | S125924 |
K2125415 | Certificate of Analysis | Sep 11, 2023 | S125924 |
I1509074 | Certificate of Analysis | Mar 17, 2023 | S125924 |
Solubility | Soluble in DMSO (77 mg/ml at 25 °C), ethanol (45 mg/ml at 25 °C), DMF (~20 mg/ml), DMSO:PBS (pH 7.2) (1:1) (~ 0.5 mg/ml), and water (<1 mg/ml at 25 °C). |
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Sensitivity | Heat sensitive;light sensitive |
Melt Point(°C) | 214 °C(dec.) |
Starting at $169.90
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38. Meng Wang, Hui Li, Yaxin Zhao, Chuanfeng Lv, Guanghua Zhou. (2019) Rhynchophylline attenuates allergic bronchial asthma by inhibiting transforming growth factor‑β1‑mediated Smad and mitogen‑activated protein kinase signaling transductions in vivo and in vitro. Experimental and Therapeutic Medicine, 17 (1): (251-259). [PMID:30651790] [10.3892/etm.2018.6909] |