Skip to the beginning of the images gallery

SB431542 - ≥98%, high purity , CAS No.301836-41-9, Inhibitor of activin A receptor type 1C;Inhibitor of transforming growth factor beta receptor 1

Moligand™
≥98%

CAS#: 301836-41-9
Formula: C₂₂H₁₆N₄O₃
Molecular Weight: 384.39
MDL number: MFCD05865244
PubChem CID: 4521392

Item Number

S125924

Grouped product items
SKU	Size	Availability	Price
S125924-10mg	10mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$94.90
S125924-50mg	50mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$355.90
S125924-100mg	100mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$664.90

ALK inhibitor

View related series

activin A receptor type 1C Inhibitor Receptor tyrosine kinase (RTK) inhibitors transforming growth factor beta receptor 1 Inhibitor

Basic Description

Synonyms	301836-41-9\|SB-431542\|SB 431542\|4-(4-(benzo[d][1,3]dioxol-5-yl)-5-(pyridin-2-yl)-1H-imidazol-2-yl)benzamide\|SB431542\|4-[4-(1,3-BENZODIOXOL-5-YL)-5-(2-PYRIDINYL)-1H-IMIDAZOL-2-YL]BENZAMIDE\|CHEMBL440084\|J1.722.247C\|E1557V1V0N\|4-[4-(1,3-benzodioxol-5-yl)-5-p
Specifications & Purity	Moligand™, ≥98%
Biochemical and Physiological Mechanisms	SB 431542 is a small molecule that acts as a specific and selective inhibitor of TGFβ RI, ACTR-IB and ACTR-IC (transforming growth factor-β superfamily type I activin receptor-like kinase (ALK) receptors ALK4, 5, and 7). Renal carcinoma studies have demon
Storage Temp	Protected from light,Store at -20°C
Shipped In	Ice chest + Ice pads
Grade	Moligand™
Action Type	INHIBITOR
Mechanism of action	Inhibitor of activin A receptor type 1C;Inhibitor of transforming growth factor beta receptor 1
Note	Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description	SB431542 is a potent and selective inhibitor of ALK5 with IC50 of 94 nM in a cell-free assay, 100-fold more selective for ALK5 than p38 MAPK and other kinases. A specific and selective inhibitor of TGF-β type I ALK receptors and Smad3.

Associated Targets

CYP1A2 Tchem Cytochrome P450 1A2 0 Activities

Discover Target: CYP1A2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

COL6A5 Tbio Collagen alpha-5(VI) chain 0 Activities

Discover Target: COL6A5

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CYP3A4 Tclin Cytochrome P450 3A4 0 Activities

Discover Target: CYP3A4

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ERBB2 Tclin Receptor tyrosine-protein kinase erbB-2 0 Activities

Discover Target: ERBB2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

EGFR Tclin Epidermal growth factor receptor 0 Activities

Discover Target: EGFR

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CDK9 Tchem Cyclin-dependent kinase 9 0 Activities

Discover Target: CDK9

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CDK18 Tchem Cyclin-dependent kinase 18 0 Activities

Discover Target: CDK18

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CDK2 Tchem Cyclin-dependent kinase 2 0 Activities

Discover Target: CDK2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CDK5 Tchem Cyclin-dependent-like kinase 5 0 Activities

Discover Target: CDK5

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

FLT4 Tclin Vascular endothelial growth factor receptor 3 0 Activities

Discover Target: FLT4

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

YES1 Tclin Tyrosine-protein kinase Yes 0 Activities

Discover Target: YES1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

TYK2 Tclin Non-receptor tyrosine-protein kinase TYK2 0 Activities

Discover Target: TYK2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

HDAC6 Tclin Histone deacetylase 6 0 Activities

Discover Target: HDAC6

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

FLT3 Tclin Receptor-type tyrosine-protein kinase FLT3 0 Activities

Discover Target: FLT3

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

FGFR1 Tclin Fibroblast growth factor receptor 1 0 Activities

Discover Target: FGFR1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

FGFR2 Tclin Fibroblast growth factor receptor 2 0 Activities

Discover Target: FGFR2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

FGFR3 Tclin Fibroblast growth factor receptor 3 0 Activities

Discover Target: FGFR3

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

MET Tclin Hepatocyte growth factor receptor 0 Activities

Discover Target: MET

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

IGF1R Tclin Insulin-like growth factor 1 receptor 0 Activities

Discover Target: IGF1R

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PLK4 Tchem Serine/threonine-protein kinase PLK4 0 Activities

Discover Target: PLK4

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PIM1 Tchem Serine/threonine-protein kinase pim-1 0 Activities

Discover Target: PIM1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PDGFRA Tclin Platelet-derived growth factor receptor alpha 0 Activities

Discover Target: PDGFRA

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PIM2 Tchem Serine/threonine-protein kinase pim-2 0 Activities

Discover Target: PIM2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PIM3 Tchem Serine/threonine-protein kinase pim-3 0 Activities

Discover Target: PIM3

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PRKG2 Tchem cGMP-dependent protein kinase 2 0 Activities

Discover Target: PRKG2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

RPS6KA2 Tchem Ribosomal protein S6 kinase alpha-2 0 Activities

Discover Target: RPS6KA2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PRKCE Tchem Protein kinase C epsilon type 0 Activities

Discover Target: PRKCE

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PRKCH Tchem Protein kinase C eta type 0 Activities

Discover Target: PRKCH

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PRKD1 Tchem Serine/threonine-protein kinase D1 0 Activities

Discover Target: PRKD1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

BTK Tclin Tyrosine-protein kinase BTK 0 Activities

Discover Target: BTK

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

AURKA Tchem Aurora kinase A 0 Activities

Discover Target: AURKA

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

AURKB Tchem Aurora kinase B 0 Activities

Discover Target: AURKB

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

FLT1 Tclin Vascular endothelial growth factor receptor 1 0 Activities

Discover Target: FLT1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

KDR Tclin Vascular endothelial growth factor receptor 2 0 Activities

Discover Target: KDR

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

AAK1 Tchem AP2-associated protein kinase 1 0 Activities

Discover Target: AAK1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

TNK2 Tclin Activated CDC42 kinase 1 0 Activities

Discover Target: TNK2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ABL1 Tclin Tyrosine-protein kinase ABL1 0 Activities

Discover Target: ABL1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ACVRL1 Tchem Serine/threonine-protein kinase receptor R3 0 Activities

Discover Target: ACVRL1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

AKT3 Tchem RAC-gamma serine/threonine-protein kinase 0 Activities

Discover Target: AKT3

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

AKT2 Tchem RAC-beta serine/threonine-protein kinase 0 Activities

Discover Target: AKT2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

AKT1 Tchem RAC-alpha serine/threonine-protein kinase 0 Activities

Discover Target: AKT1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CLK3 Tchem Dual specificity protein kinase CLK3 0 Activities

Discover Target: CLK3

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CLK1 Tchem Dual specificity protein kinase CLK1 0 Activities

Discover Target: CLK1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

GSK3B Tclin Glycogen synthase kinase-3 beta 0 Activities

Discover Target: GSK3B

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

KIT Tclin Mast/stem cell growth factor receptor Kit 0 Activities

Discover Target: KIT

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

NTRK1 Tclin High affinity nerve growth factor receptor 0 Activities

Discover Target: NTRK1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

MAP2K1 Tclin Dual specificity mitogen-activated protein kinase kinase 1 0 Activities

Discover Target: MAP2K1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	4-[4-(1,3-benzodioxol-5-yl)-5-pyridin-2-yl-1H-imidazol-2-yl]benzamide
INCHI	InChI=1S/C22H16N4O3/c23-21(27)13-4-6-14(7-5-13)22-25-19(20(26-22)16-3-1-2-10-24-16)15-8-9-17-18(11-15)29-12-28-17/h1-11H,12H2,(H2,23,27)(H,25,26)
InChi Key	FHYUGAJXYORMHI-UHFFFAOYSA-N
Canonical SMILES	C1OC2=C(O1)C=C(C=C2)C3=C(NC(=N3)C4=CC=C(C=C4)C(=O)N)C5=CC=CC=N5
Isomeric SMILES	C1OC2=C(O1)C=C(C=C2)C3=C(NC(=N3)C4=CC=C(C=C4)C(=O)N)C5=CC=CC=N5
PubChem CID	4521392
Molecular Weight	384.39

Database links

ChEMBL Ligand	CHEMBL440084
PubChem CID	4521392
CAS Registry No.	301836-41-9
Wikipedia	SB-431542
RCSB PDB Ligand	85, 085

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section

6 results found

Lot Number	Certificate Type	Date	Item
G2430449	Certificate of Analysis	Jul 16, 2024	S125924
G2430450	Certificate of Analysis	Jul 16, 2024	S125924
G2430451	Certificate of Analysis	Jul 16, 2024	S125924
G2430476	Certificate of Analysis	Jul 16, 2024	S125924
K2125415	Certificate of Analysis	Sep 11, 2023	S125924
I1509074	Certificate of Analysis	Mar 17, 2023	S125924

Chemical and Physical Properties

Solubility	Soluble in DMSO (77 mg/ml at 25 °C), ethanol (45 mg/ml at 25 °C), DMF (~20 mg/ml), DMSO:PBS (pH 7.2) (1:1) (~ 0.5 mg/ml), and water (<1 mg/ml at 25 °C).
Sensitivity	Heat sensitive；light sensitive
Melt Point(°C)	214 °C(dec.)

Alternative Products

FAQs and Articles

FAQ

New Uses for Organoids

Categories: Technical articles

Tags:

Organoids

References

1. Callahan JF, Burgess JL, Fornwald JA, Gaster LM, Harling JD, Harrington FP, Heer J, Kwon C, Lehr R, Mathur A et al.. (2002) Identification of novel inhibitors of the transforming growth factor beta1 (TGF-beta1) type 1 receptor (ALK5).. J Med Chem, 45 (5): (999-1001). [PMID:11855979]
2. Inman GJ, Nicolás FJ, Callahan JF, Harling JD, Gaster LM, Reith AD, Laping NJ, Hill CS. (2002) SB-431542 is a potent and specific inhibitor of transforming growth factor-beta superfamily type I activin receptor-like kinase (ALK) receptors ALK4, ALK5, and ALK7.. Mol Pharmacol, 62 (1): (65-74). [PMID:12065756]
3. Minutti CM et al.. (2019) A Macrophage-Pericyte Axis Directs Tissue Restoration via Amphiregulin-Induced Transforming Growth Factor Beta Activation.. Immunity, 50 (3): (645-654.e6). [PMID:30770250]
4. Liberti DC et al.. (2021) Alveolar epithelial cell fate is maintained in a spatially restricted manner to promote lung regeneration after acute injury.. Cell Rep, 35 (6): (109092). [PMID:33979629]
5. Chen H et al.. (2012) Airway epithelial progenitors are region specific and show differential responses to bleomycin-induced lung injury.. Stem Cells, 30 (9): (1948-60). [PMID:22696116]
6. André PA et al.. (2015) BARD1 mediates TGF-ß signaling in pulmonary fibrosis.. Respir Res, 16 (118). [PMID:26415510]
7. Salehi H et al.. (2019) Application of Hanging Drop Culture for Retinal Precursor-Like Cells Differentiation of Human Adipose-Derived Stem Cells Using Small Molecules.. J Mol Neurosci, [PMID:31363912]
8. Kutsche LK et al.. (2018) Combined Experimental and System-Level Analyses Reveal the Complex Regulatory Network of miR-124 during Human Neurogenesis.. Cell Syst, 7 (4): (438-452.e8). [PMID:30292704]
9. Konishi S et al.. (2022) Defined conditions for long-term expansion of murine and human alveolar epithelial stem cells in three-dimensional cultures.. STAR Protoc, 3 (2): (101447). [PMID:35712012]
10. Abarca-Buis R et al.. (2020) Control of fibrosis by TGFß signalling modulation promotes redifferentiation during limited regeneration of mouse ear.. Int J Dev Biol, 64 (7-8-9): (423-432). [PMID:33063836]
11. Keatinge M et al.. (2021) CRISPR gRNA phenotypic screening in zebrafish reveals pro-regenerative genes in spinal cord injury.. PLoS Genet, 17 (4): (e1009515). [PMID:33914736]
12. Xiang Y et al.. (2020) Dysregulation of BRD4 Function Underlies the Functional Abnormalities of MeCP2 Mutant Neurons.. Mol Cell, 79 (84-98.e9). [PMID:32526163]
13. . (1991) From the Centers for Disease Control. AIDS Clinical Trials Information Service.. JAMA, 266 (13): (1756). [PMID:1653860]
14. Teisanu RM et al.. (2011) Functional analysis of two distinct bronchiolar progenitors during lung injury and repair.. Am J Respir Cell Mol Biol, 44 (6): (794-803). [PMID:20656948]
15. Xiang Y et al.. (2018) Generation and Fusion of Human Cortical and Medial Ganglionic Eminence Brain Organoids.. Curr Protoc Stem Cell Biol, 47 [PMID:30854156]
16. Xiang Y et al.. (2020) Generation of Regionally Specified Human Brain Organoids Resembling Thalamus Development.. STAR Protoc, 1 [PMID:33103124]
17. Zong W et al.. (2015) Estradiol plays a role in regulating the expression of lysyl oxidase family genes in mouse urogenital tissues and human Ishikawa cells.. J Zhejiang Univ Sci B, 16 (10): (857-64). [PMID:26465133]
18. Xiang Y et al.. (2019) hESC-Derived Thalamic Organoids Form Reciprocal Projections When Fused with Cortical Organoids.. Cell Stem Cell, 24 (3): (487-497.e7). [PMID:30799279]
19. Wimmer RA et al.. (2019) Human blood vessel organoids as a\xa0model of\xa0diabetic vasculopathy.. Nature, 565 (7740): (505-510). [PMID:30651639]
20. Katsura H et al.. (2020) Human Lung Stem Cell-Based Alveolospheres Provide Insights into SARS-CoV-2-Mediated Interferon Responses and Pneumocyte Dysfunction.. Cell Stem Cell, 27 (6): (890-904.e8). [PMID:33128895]
21. Malaguti M et al.. (2019) Id1 Stabilizes Epiblast Identity by Sensing Delays in Nodal Activation and Adjusting the Timing of Differentiation.. Dev Cell, 50 (4): (462-477.e5). [PMID:31204172]
22. Khanam R et al.. (2022) Identification of Adamts4 as a novel adult cardiac injury biomarker with therapeutic implications in patients with cardiac injuries.. Sci Rep, 12 (9898). [PMID:35701493]
23. Ashja-Arvan M et al.. (2020) Impact of IFN-ß and LIF overexpression on human adipose-derived stem cells properties.. J Cell Physiol, [PMID:32324266]
24. Kim D et al.. (2015) Impaired osteogenesis in Menkes disease-derived induced pluripotent stem cells.. Stem Cell Res Ther, 6 (160). [PMID:26347346]
25. Sabate-Soler S et al.. (2022) Microglia integration into human midbrain organoids leads to increased neuronal maturation and functionality.. Glia, 70 (7): (1267-1288). [PMID:35262217]
26. Xu M et al.. (2021) MicroRNA-17-5p restrains the dysfunction of Ang-II induced podocytes by suppressing secreted modular calcium-binding protein 2 via NF-κB and TGFβ signaling.. Environ Toxicol, 36 (7): (1402-1411). [PMID:33835671]
27. Liu H et al.. (2022) MicroRNA-642b-3p functions as an oncomiR in gastric cancer by down-regulating the CUB and sushi multiple domains protein 1/smad axis.. Bioengineered, 13 (4): (9613-9627). [PMID:35412956]
28. Zhu K et al.. (2014) MiR-302c inhibits tumor growth of hepatocellular carcinoma by suppressing the endothelial-mesenchymal transition of endothelial cells.. Sci Rep, 4 (5524). [PMID:25027009]
29. Hargus G et al.. (2014) Origin-dependent neural cell identities in differentiated human iPSCs in vitro and after transplantation into the mouse brain.. Cell Rep, 8 (6): (1697-703). [PMID:25220454]
30. Zhang M et al.. (2022) Prkg2 regulates alveolar type 2-mediated re-alveolarization.. Stem Cell Res Ther, 13 (111). [PMID:35313961]
31. Esteves TC et al.. (2011) Somatic cell nuclear reprogramming of mouse oocytes endures beyond reproductive decline.. Aging Cell, 10 (80-95). [PMID:20969722]
32. Ateaque S et al.. (2022) Selective activation and down-regulation of Trk receptors by neurotrophins in human neurons co-expressing TrkB and TrkC.. J Neurochem, 161 (6): (463-477). [PMID:35536742]
33. Yang YH et al.. (2016) Stromal Tissue Rigidity Promotes Mesenchymal Stem Cell-Mediated Corneal Wound Healing Through the Transforming Growth Factor ß Signaling Pathway.. Stem Cells, 34 (10): (2525-2535). [PMID:27250866]
34. Kelly TJ et al.. (2019) Temporal Control of the TGF-ß Signaling Network by Mouse ESC MicroRNA Targets of Different Affinities.. Cell Rep, 29 (9): (2702-2717.e7). [PMID:31775039]
35. Kang Y et al.. (2016) Transforming Growth Factor-ß Limits Secretion of Lumican by Activated Stellate Cells within Primary Pancreatic Adenocarcinoma Tumors.. Clin Cancer Res, 22 (19): (4934-4946). [PMID:27126993]
36. Epping MT et al.. (2015) TSPYL2 is an essential component of the REST/NRSF transcriptional complex for TGFß signaling activation.. Cell Death Differ, 22 (8): (1353-62). [PMID:25613376]

Solution Calculators

Molarity Calculator

Determine the necessary mass, volume, or concentration for preparing a solution.

Dilution Calculator

Determine the dilution needed to prepare a stock solution.