SB505124 - ≥98%, high purity , CAS No.694433-59-5, Inhibitor of transforming growth factor beta receptor 1

Item Number

S126125

• Synonyms: 694433-59-5 | SB-505124 | SB505124 | 2-(4-(benzo[d][1,3]dioxol-5-yl)-2-tert-butyl-1H-imidazol-5-yl)-6-methylpyridine | SB 505124 | TGF-beta RI Inhibitor III | 2-(4-(benzo[d][1,3]dioxol-5-yl)-2-(tert-butyl)-1H-imidazol-5-yl)-6-methylpyridine | CHEMBL226838 | 2-(5-benzo[1,
• Specifications & Purity: Moligand™, ≥98%
• Biochemical and Physiological Mechanisms: SB-505124 is an inhibitor of activin receptor-like kinase (ALK-5). SB-505124 is demonstrated to suppress the action of transforming growth factor-B (TGF-B) both in vitro and in vivo.Potent, reversible, competitive ALK5 inhibitor (IC 50 values are 47 and 1
• Storage Temp: Store at -20°C
• Shipped In: Ice chest + Ice pads
• Grade: Moligand™
• Action Type: INHIBITOR
• Mechanism of action: Inhibitor of transforming growth factor beta receptor 1
• Note: Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Product Description

SB505124 is a selective inhibitor of TGFβR for ALK4, ALK5 with IC50 of 129 nM and 47 nM in cell-free assays, respectively, also inhibits ALK7, but does not inhibit ALK1, 2, 3, or 6.
An inhibitor of Activin receptor-like kinase 5