Determine the necessary mass, volume, or concentration for preparing a solution.
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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S125513-1mg | 1mg | In stock | $23.90 | |
S125513-5mg | 5mg | In stock | $97.90 | |
S125513-10mg | 10mg | In stock | $162.90 | |
S125513-50mg | 50mg | In stock | $612.90 |
Potent and selective B-Raf kinase inhibitor
Specifications & Purity | ≥98% |
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Biochemical and Physiological Mechanisms | SB 590885 is known to be a potent Raf-B inhibitor. The compound has shown selectivity for Raf-B against 46 other kinases. SB 590885 has been shown to decreases anchorage-independent growth of melanoma cell lines and also known to inhibit phosphorylation a |
Storage Temp | Store at -20°C |
Shipped In | Ice chest + Ice pads |
Note | Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details. |
Product Description | SB590885 is a potent B-Raf inhibitor with Ki of 0.16 nM, 11-fold greater selectivity for B-Raf over c-Raf, no inhibition to other human kinases. |
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Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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IUPAC Name | (NE)-N-[5-[2-[4-[2-(dimethylamino)ethoxy]phenyl]-5-pyridin-4-yl-1H-imidazol-4-yl]-2,3-dihydroinden-1-ylidene]hydroxylamine |
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INCHI | InChI=1S/C27H27N5O2/c1-32(2)15-16-34-22-7-3-19(4-8-22)27-29-25(18-11-13-28-14-12-18)26(30-27)21-5-9-23-20(17-21)6-10-24(23)31-33/h3-5,7-9,11-14,17,33H,6,10,15-16H2,1-2H3,(H,29,30)/b31-24+ |
InChi Key | MLSAQOINCGAULQ-QFMPWRQOSA-N |
Canonical SMILES | CN(C)CCOC1=CC=C(C=C1)C2=NC(=C(N2)C3=CC=NC=C3)C4=CC5=C(C=C4)C(=NO)CC5 |
Isomeric SMILES | CN(C)CCOC1=CC=C(C=C1)C2=NC(=C(N2)C3=CC=NC=C3)C4=CC5=C(C=C4)/C(=N/O)/CC5 |
WGK Germany | 3 |
PubChem CID | 135421339 |
Molecular Weight | 453.54 |
Enter Lot Number to search for COA:
Find and download the COA for your product by matching the lot number on the packaging.
Lot Number | Certificate Type | Date | Item |
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G2219915 | Certificate of Analysis | May 15, 2024 | S125513 |
G2219933 | Certificate of Analysis | May 15, 2024 | S125513 |
G2219934 | Certificate of Analysis | May 15, 2024 | S125513 |
G2220079 | Certificate of Analysis | May 15, 2024 | S125513 |
Solubility | DMSO 5 mg/mL; Water <1 mg/mL; Ethanol <1 mg/mL |
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WGK Germany | 3 |
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