SBP-7455 - 10mM in DMSO, high purity , CAS No.1884222-74-5

Item Number

S422307

Grouped product items
SKU	Size	Availability	Price	Qty
S422307-1ml	1ml	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$241.90

Basic Description

Specifications & Purity	Moligand™, 10mM in DMSO
Biochemical and Physiological Mechanisms	SBP-7455 is a dual-Specific ULK1/2 autophagy inhibitor with IC50s of 13 nM and 476 nM for ULK1 and ULK2 in ADP-Glo assay, respectively.
Storage Temp	Store at -80°C
Shipped In	Ice chest + Ice pads
Grade	Moligand™
Product Description	Information SBP-7455 (compound 26) is a dual inhibitor of ULK1 and ULK2 that potently inhibits ULK1/2 enzymatic activity in vitro and in vivo. SBP-7455 inhibits starvation-induced autophagic flux in TNBC cells.

Associated Targets(Human)

ULK1 Tchem Serine/threonine-protein kinase ULK1 (1 Activities)

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

MDA-MB-468 (9477 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

ULK2 Tchem Serine/threonine-protein kinase ULK2 (652 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Names and Identifiers

IUPAC Name	4-N-cyclopropyl-2-N-(3,4-dimethoxyphenyl)-5-(trifluoromethyl)pyrimidine-2,4-diamine
INCHI	InChI=1S/C16H17F3N4O2/c1-24-12-6-5-10(7-13(12)25-2)22-15-20-8-11(16(17,18)19)14(23-15)21-9-3-4-9/h5-9H,3-4H2,1-2H3,(H2,20,21,22,23)
InChi Key	BQROJYIEHOOQBY-UHFFFAOYSA-N
Canonical SMILES	COC1=C(C=C(C=C1)NC2=NC=C(C(=N2)NC3CC3)C(F)(F)F)OC
Isomeric SMILES	COC1=C(C=C(C=C1)NC2=NC=C(C(=N2)NC3CC3)C(F)(F)F)OC
PubChem CID	132178569
Molecular Weight	354.33

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Basic Description