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SCH 221510 - ≥98%, high purity , CAS No.322473-89-2, Agonist of δ receptor;Agonist of κ receptor;Agonist of μ receptor;Agonist of NOP receptor

Moligand™
≥98%

CAS#: 322473-89-2
Formula: C₂₈H₃₁NO
Molecular Weight: 397.55
PubChem CID: 9887077

Item Number

S287959

Grouped product items
SKU	Size	Availability	Price
S287959-5mg	5mg	In stock	$143.90
S287959-10mg	10mg	In stock	$221.90
S287959-25mg	25mg	In stock	$498.90
S287959-50mg	50mg	In stock	$931.90

Potent and selective NOP agonist

View related series

NOP receptor Agonist δ receptor Agonist κ receptor Agonist μ receptor Agonist

Basic Description

Synonyms	SCH 221510\|322473-89-2\|Sch221510\|8-[bis(2-methylphenyl)methyl]-3-phenyl-8-azabicyclo[3.2.1]octan-3-ol\|CHEMBL513136\|3-Endo-8-[bis(2-methylphenyl)methyl]-3-phenyl-8-azabicyclo[3.2.1]octan-3-ol\|Sch-221510\|GTPL8868\|SCHEMBL15795054\|DTXSID10432414\|BDBM50258880\|
Specifications & Purity	Moligand™, ≥98%
Biochemical and Physiological Mechanisms	Potent and selective nociceptin opioid receptor (NOP) agonist (EC50values are 12, 693, 683 and 8071 nM, and Kivalues are 0.3, 65, 131 and 2854 nM at NOP,μ-,κ- andδ-opioid receptors respectively). Exhibits anxiolytic-like activity at doses that have no eff
Storage Temp	Room temperature
Shipped In	Normal
Grade	Moligand™
Action Type	AGONIST
Mechanism of action	Agonist of δ receptor;Agonist of κ receptor;Agonist of μ receptor;Agonist of NOP receptor

Associated Targets

CX3CR1 Tchem CX3C chemokine receptor 1 0 Activities

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GPR35 Tchem G-protein coupled receptor 35 0 Activities

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BRD4 Tchem Bromodomain-containing protein 4 0 Activities

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CDK2 Tchem Cyclin-dependent kinase 2 0 Activities

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FFAR4 Tchem Free fatty acid receptor 4 0 Activities

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HDAC6 Tclin Histone deacetylase 6 0 Activities

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FPR2 Tchem N-formyl peptide receptor 2 0 Activities

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FGFR3 Tclin Fibroblast growth factor receptor 3 0 Activities

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CSNK1D Tchem Casein kinase I isoform delta 0 Activities

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S1PR1 Tclin Sphingosine 1-phosphate receptor 1 0 Activities

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TRIM24 Tchem Transcription intermediary factor 1-alpha 0 Activities

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C5AR1 Tclin C5a anaphylatoxin chemotactic receptor 1 0 Activities

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BRPF1 Tchem Peregrin 0 Activities

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AURKA Tchem Aurora kinase A 0 Activities

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ADRB2 Tclin Beta-2 adrenergic receptor 0 Activities

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APLNR Tchem Apelin receptor 0 Activities

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ABL1 Tclin Tyrosine-protein kinase ABL1 0 Activities

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ADRA2A Tclin Alpha-2A adrenergic receptor 0 Activities

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ADGRF1 Tbio Adhesion G-protein coupled receptor F1 0 Activities

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AGTR1 Tclin Type-1 angiotensin II receptor 0 Activities

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GSK3B Tclin Glycogen synthase kinase-3 beta 0 Activities

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GPR119 Tclin Glucose-dependent insulinotropic receptor 0 Activities

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GLP1R Tclin Glucagon-like peptide 1 receptor 0 Activities

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Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

OPRD1 Tclin Delta-type opioid receptor 1 Activities

Discover Target: OPRD1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

OPRK1 Tclin Kappa-type opioid receptor 1 Activities

Discover Target: OPRK1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

OPRL1 Tchem Nociceptin receptor 6 Activities

Discover Target: OPRL1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

OPRM1 Tclin Mu-type opioid receptor 2 Activities

Discover Target: OPRM1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

MAPK1 Tchem Mitogen-activated protein kinase 1 0 Activities

Discover Target: MAPK1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	8-[bis(2-methylphenyl)methyl]-3-phenyl-8-azabicyclo[3.2.1]octan-3-ol
INCHI	InChI=1S/C28H31NO/c1-20-10-6-8-14-25(20)27(26-15-9-7-11-21(26)2)29-23-16-17-24(29)19-28(30,18-23)22-12-4-3-5-13-22/h3-15,23-24,27,30H,16-19H2,1-2H3
InChi Key	LOSJNRBXNQTUNT-UHFFFAOYSA-N
Canonical SMILES	CC1=CC=CC=C1C(C2=CC=CC=C2C)N3C4CCC3CC(C4)(C5=CC=CC=C5)O
Isomeric SMILES	CC1=CC=CC=C1C(C2=CC=CC=C2C)N3C4CCC3CC(C4)(C5=CC=CC=C5)O
PubChem CID	9887077
Molecular Weight	397.55

PubChem CID

ChEMBL Ligand

CAS Registry No.

GPCRdb Ligand

Certificates

Certificate of Analysis(COA)

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4 results found

Lot Number	Certificate Type	Date	Item
F2328712	Certificate of Analysis	Jun 06, 2023	S287959
F2328713	Certificate of Analysis	Jun 06, 2023	S287959
F2328714	Certificate of Analysis	Jun 06, 2023	S287959
F2328715	Certificate of Analysis	Jun 06, 2023	S287959

References

1. Varty GB, Lu SX, Morgan CA, Cohen-Williams ME, Hodgson RA, Smith-Torhan A, Zhang H, Fawzi AB, Graziano MP, Ho GD et al.. (2008) The anxiolytic-like effects of the novel, orally active nociceptin opioid receptor agonist 8-[bis(2-methylphenyl)methyl]-3-phenyl-8-azabicyclo[3.2.1]octan-3-ol (SCH 221510).. J Pharmacol Exp Ther, 326 (2): (672-82). [PMID:18492950]

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