SDHB Antibody - Primary antibody, specific to SDHB, Rabbit IgG

Features and benefits
  • Short Overview:

    Recombinant; Rabbit anti Human SDHB Antibody; WB, IP; Unconjugated

  • Species reactivity(Reacts with): Human,Mouse,Rat
  • Isotype: Rabbit IgG
    Application:
  • IP
  • WB
Item Number
Ab126854
Grouped product items
SKUSizeAvailabilityPrice Qty
Ab126854-10μl
10μl
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$59.90
Ab126854-50μl
50μl
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$209.90
Ab126854-100μl
100μl
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$329.90
Ab126854-1ml
1ml
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$2,099.90

Recombinant; Rabbit anti Human SDHB Antibody; WB, IP; Unconjugated

Basic Description

Product NameSDHB Antibody - Primary antibody, specific to SDHB, Rabbit IgG
SynonymsCWS2 antibody; DHSB_HUMAN antibody; FLJ92337 antibody; Ip antibody; Iron sulfur subunit antibody; Iron sulfur subunit of complex II antibody; Iron-sulfur subunit of complex II antibody; mitochondrial antibody; PGL 4 antibody; PGL4 antibody; SDH 1 antibody
Specifications & PurityExactAb™, Validated, Recombinant, Lot by Lot
Biochemical and Physiological MechanismsIron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).
Host speciesRabbit
SpecificitySDHB
ImmunogenA synthetic peptide derived from human SDHB (AA 1-280).
Positive ControlWB: HeLa, Jurkat, HepG2, MCF7, Mouse heart, liver, kidney, slpeen, lung, brain, skin, Rat heart, liver, kidney, brain, spleen, lung, skin lysates. IP: HeLa lysates.
ConjugationUnconjugated
GradeExactAb™, Recombinant, Validated
Product Description

Rabbit anti Human SDHB Antibody, Recombinant, could be used for WB, IP and so on.

Product Properties

IsotypeRabbit IgG
Light Chain Typekappa
SDS-PAGE150 kDa
Purification MethodProtein A purified
FormLiquid
ConcentrationLot by Lot
Storage TempStore at -20°C,Avoid repeated freezing and thawing
Shipped InIce chest + Ice pads
Stability And StorageStore at 4°C short term (1-2 weeks). Store at -20°C long term (24 months). Upon delivery aliquot. Avoid freeze/thaw cycle.

Associated Targets(Human)

SDHB Tchem Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
SDHB Tchem Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial (56 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Application

ApplicationDilution info
WB

1/1000 - 1/2000

IP

1/20-1/50

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

Related Documents

References

1. Kita, K K, Oya, H H, Gennis, R B RB, Ackrell, B A BA and Kasahara, M M..  (1990)  Human complex II (succinate-ubiquinone oxidoreductase): cDNA cloning of iron sulfur (Ip) subunit of liver mitochondria..  Biochemical and biophysical research communications,    (15):   [PMID:2302193]
2. Gould, S J SJ, Subramani, S S and Scheffler, I E IE..  (1989)  Use of the DNA polymerase chain reaction for homology probing: isolation of partial cDNA or genomic clones encoding the iron-sulfur protein of succinate dehydrogenase from several species..  Proceedings of the National Academy of Sciences of the United States of America,      [PMID:2494655]
3. Au, H C HC and 5 more authors..  (1995)  Structural organization of the gene encoding the human iron-sulfur subunit of succinate dehydrogenase..  Gene,    (4):   [PMID:7622059]
4. Astuti, D D and 9 more authors..  (2001)  Gene mutations in the succinate dehydrogenase subunit SDHB cause susceptibility to familial pheochromocytoma and to familial paraganglioma..  American journal of human genetics,      [PMID:11404820]
5. Baysal, B E BE and 11 more authors..  (2002)  Prevalence of SDHB, SDHC, and SDHD germline mutations in clinic patients with head and neck paragangliomas..  Journal of medical genetics,      [PMID:11897817]
6. Neumann, Hartmut P H HP and 29 more authors..  (2002)  Germ-line mutations in nonsyndromic pheochromocytoma..  The New England journal of medicine,    (9):   [PMID:12000816]
7. Young, Abbie L AL, Baysal, Bora E BE, Deb, Arjun A and Young, William F WF..  (2002)  Familial malignant catecholamine-secreting paraganglioma with prolonged survival associated with mutation in the succinate dehydrogenase B gene..  The Journal of clinical endocrinology and metabolism,      [PMID:12213855]
8. Benn, Diana E DE and 9 more authors..  (2003)  Novel succinate dehydrogenase subunit B (SDHB) mutations in familial phaeochromocytomas and paragangliomas, but an absence of somatic SDHB mutations in sporadic phaeochromocytomas..  Oncogene,    (6):   [PMID:12618761]
9. Gimenez-Roqueplo, Anne-Paule AP and 10 more authors..  (2003)  Mutations in the SDHB gene are associated with extra-adrenal and/or malignant phaeochromocytomas..  Cancer research,    (1):   [PMID:14500403]
10. Maier-Woelfle, Margarete M and 10 more authors..  (2004)  A novel succinate dehydrogenase subunit B gene mutation, H132P, causes familial malignant sympathetic extraadrenal paragangliomas..  The Journal of clinical endocrinology and metabolism,      [PMID:14715873]
11. Astuti, Dewi D and 13 more authors..  (2003)  Genetic analysis of mitochondrial complex II subunits SDHD, SDHB and SDHC in paraganglioma and phaeochromocytoma susceptibility..  Clinical endocrinology,      [PMID:14974914]
12. Neumann, Hartmut P H HP and 16 more authors..  (2004)  Distinct clinical features of paraganglioma syndromes associated with SDHB and SDHD gene mutations..  JAMA,    (25):   [PMID:15328326]
13. McDonnell, Ciara M CM, Benn, Diana E DE, Marsh, Deborah J DJ, Robinson, Bruce G BG and Zacharin, Margaret R MR..  (2004)  K40E: a novel succinate dehydrogenase (SDH)B mutation causing familial phaeochromocytoma and paraganglioma..  Clinical endocrinology,      [PMID:15473885]
14. Gregory, S G SG and 178 more authors..  (2006)  The DNA sequence and biological annotation of human chromosome 1..  Nature,    (18):   [PMID:16710414]
15. Kullberg, Morgan M, Nilsson, Maria A MA, Arnason, Ulfur U, Harley, Eric H EH and Janke, Axel A..  (2006)  Housekeeping genes for phylogenetic analysis of eutherian relationships..  Molecular biology and evolution,      [PMID:16751257]
16. van Nederveen, Francien H FH, Korpershoek, Esther E, Lenders, Jacques W M JW, de Krijger, Ronald R RR and Dinjens, Winand N M WN..  (2007)  Somatic SDHB mutation in an extraadrenal pheochromocytoma..  The New England journal of medicine,    (19):   [PMID:17634472]
17. .  (2007)  Familial gastrointestinal stromal tumors and germ-line mutations..  The New England journal of medicine,    (6):   [PMID:17804857]
18. Ni, Ying Y and 9 more authors..  (2008)  Germline mutations and variants in the succinate dehydrogenase genes in Cowden and Cowden-like syndromes..  American journal of human genetics,      [PMID:18678321]
19. Alston, Charlotte L CL and 12 more authors..  (2012)  Recessive germline SDHA and SDHB mutations causing leukodystrophy and isolated mitochondrial complex II deficiency..  Journal of medical genetics,      [PMID:22972948]
20. Helman, Guy G and 13 more authors..  (2016)  Magnetic resonance imaging spectrum of succinate dehydrogenase-related infantile leukoencephalopathy..  Annals of neurology,      [PMID:26642834]
21. Maio, Nunziata N and 9 more authors..  (2016)  Disease-Causing SDHAF1 Mutations Impair Transfer of Fe-S Clusters to SDHB..  Cell metabolism,    (9):   [PMID:26749241]
22. Ardissone, Anna and 5 more authors..  (2015)  Mitochondrial leukoencephalopathy and complex II deficiency associated with a recessive SDHB mutation with reduced penetrance..  Molecular genetics and metabolism reports,      [PMID:26925370]
23. Grønborg, Sabine S and 10 more authors..  (2017)  Leukoencephalopathy due to Complex II Deficiency and Bi-Allelic SDHB Mutations: Further Cases and Implications for Genetic Counselling..  JIMD reports,      [PMID:27604842]
24. Kaur, Parneet; Sharma, Suvasini; Kadavigere, Rajagopal; Girisha, Katta Mohan and Shukla, Anju..  (2020)  Novel variant p.(Ala102Thr) in SDHB causes mitochondrial complex II deficiency: Case report and review of the literature..  Annals of human genetics,      [PMID:32124427]
25. Saribas, Sami and Safak, Mahmut..  (2020)  A Comprehensive Proteomics Analysis of the JC Virus (JCV) Large and Small Tumor Antigen Interacting Proteins: Large T Primarily Targets the Host Protein Complexes with V-ATPase and Ubiquitin Ligase Activities While Small t Mostly Associates with Those Having Phosphatase and Chromatin-Remodeling Functions..  Viruses,    (20):   [PMID:33092197]

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