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SDZ 220-581 - ≥98%(HPLC), high purity , CAS No.174575-17-8
Competitive NMDA antagonist
Basic Description Synonyms CS-1475 | LMGP10010012 | alpha-Amino-2'-chloro-5-(phosphonomethyl)(1,1'-biphenyl)-3-propanoic acid | HMS3412C08 | Sdz 220-581 | SDZ220581 | Sdz-220-581 | SDZ220-581 | (alphaS)-alpha-Amino-2'-chloro-5-(phosphonomethyl)[1,1'-biphenyl]-3-propanoic acid | Abi Specifications & Purity ≥98%(HPLC) Biochemical and Physiological Mechanisms Competitive NMDA receptor antagonist (pKi= 7.7). Centrally active following oral administration (ED50< 3.2 mg/kg for protection against MES-induced seizures). Storage Temp Room temperature Shipped In Normal
Associated Targets(Human) Associated Targets(non-human) Mechanisms of Action Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References
Names and Identifiers IUPAC Name (2S)-2-amino-3-[3-(2-chlorophenyl)-5-(phosphonomethyl)phenyl]propanoic acid INCHI InChI=1S/C16H17ClNO5P/c17-14-4-2-1-3-13(14)12-6-10(8-15(18)16(19)20)5-11(7-12)9-24(21,22)23/h1-7,15H,8-9,18H2,(H,19,20)(H2,21,22,23)/t15-/m0/s1 InChi Key VBRJFXSFCYEZMQ-HNNXBMFYSA-N Canonical SMILES C1=CC=C(C(=C1)C2=CC(=CC(=C2)CP(=O)(O)O)CC(C(=O)O)N)Cl Isomeric SMILES C1=CC=C(C(=C1)C2=CC(=CC(=C2)CP(=O)(O)O)C[C@@H](C(=O)O)N)Cl PubChem CID 128019 Molecular Weight 369.74
Chemical and Physical Properties Solubility Solvent:DMSO, Max Conc. mg/mL: 9.24, Max Conc. mM: 25 with gentle warming; Solvent:1.1eq. NaOH, Max Conc. mg/mL: 36.97, Max Conc. mM: 100
Safety and Hazards(GHS) Pictogram(s) GHS07 Signal Warning Hazard Statements H315: Causes skin irritation
H319: Causes serious eye irritation
H335: May cause respiratory irritation
Precautionary Statements P261: Avoid breathing dust/fume/gas/mist/vapors/spray.
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352: IF ON SKIN: wash with plenty of water.
P321: Specific treatment (see ... on this label).
P405: Store locked up.
P501: Dispose of contents/container to ...
P264: Wash hands [and …] thoroughly after handling.
P271: Use only outdoors or in a well-ventilated area.
P304+P340: IF INHALED: Remove person to fresh air and keep comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P362+P364: Take off contaminated clothing and wash it before reuse.
P264+P265: Wash hands [and …] thoroughly after handling. Do not touch eyes.
P337+P317: If eye irritation persists: Get medical help.
P332+P317: If skin irritation occurs: Get medical help.
P319: Get medical help if you feel unwell.
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