Skip to the beginning of the images gallery

Seltorexant - 98%, high purity , CAS No.1293281-49-8, Antagonist of OX 1 receptor;Antagonist of OX 2 receptor

Moligand™

≥98%

CAS#: 1293281-49-8
Formula: C₂₁H₂₂FN₇O
Molecular Weight: 407.44
EC Number: 813-814-3
PubChem CID: 67116280

Item Number

S412988

Grouped product items
SKU	Size	Availability	Price
S412988-1mg	1mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$36.90
S412988-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$85.90
S412988-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$119.90
S412988-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$199.90
S412988-50mg	50mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$359.90
S412988-100mg	100mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$512.90

View related series

GPCR/G Protein Neuronal Signaling Orexin Receptor (OX Receptor) OX1 receptor Antagonist OX2 receptor Antagonist

Basic Description

Synonyms	JNJ42847922 \| JNJ-42847922 \| ((3aR,6aS)-5-(4,6-dimethylpyrimidin- 2-yl)hexahydropyrrolo(3,4-c)pyrrol-2(1H)-yl)(2-fluoro- 6-(2H-1,2,3-triazol-2-yl)phenyl)methanone \| Seltorexant (USAN/INN) \| JNJ-922 \| [2-(4,6-dimethylpyrimidin-2-yl)-1,3,3a,4,6,6a-hexahydro
Specifications & Purity	Moligand™, ≥98%
Biochemical and Physiological Mechanisms	Seltorexant (JNJ-42847922) is a potent, selective and orally active antagonist of orexin-2 receptor (OX2R) with pKi of 8.0 and 8.1 for human OX2R and rat OX2R, respectively. Seltorexant (JNJ-42847922) crosses the blood-brain barrier and quickly occupies O
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Grade	Moligand™
Action Type	ANTAGONIST
Mechanism of action	Antagonist of OX 1 receptor;Antagonist of OX 2 receptor
Product Description	Information Seltorexant (JNJ-42847922) is a potent, selective and orally active antagonist of orexin-2 receptor (OX2R) with pKi of 8.0 and 8.1 for human OX2R and rat OX2R, respectively. Seltorexant (JNJ-42847922) crosses the blood-brain barrier and quickly occupies OX2R binding sites in the rat brain.

Associated Targets(Human)

HCRTR1 Tclin Orexin receptor type 1 (2 Activities)

Discover Target: HCRTR1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

HCRTR2 Tclin Orexin receptor type 2 (4 Activities)

Discover Target: HCRTR2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

HCRTR1 Tclin Orexin receptor 1 (5435 Activities)

Discover Target: HCRTR1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

HCRTR2 Tclin Orexin receptor 2 (5902 Activities)

Discover Target: HCRTR2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Names and Identifiers

IUPAC Name	[2-(4,6-dimethylpyrimidin-2-yl)-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-5-yl]-[2-fluoro-6-(triazol-2-yl)phenyl]methanone
INCHI	InChI=1S/C21H22FN7O/c1-13-8-14(2)26-21(25-13)28-11-15-9-27(10-16(15)12-28)20(30)19-17(22)4-3-5-18(19)29-23-6-7-24-29/h3-8,15-16H,9-12H2,1-2H3
InChi Key	SQOCEMCKYDVLMM-UHFFFAOYSA-N
Canonical SMILES	CC1=CC(=NC(=N1)N2CC3CN(CC3C2)C(=O)C4=C(C=CC=C4F)N5N=CC=N5)C
Isomeric SMILES	CC1=CC(=NC(=N1)N2CC3CN(CC3C2)C(=O)C4=C(C=CC=C4F)N5N=CC=N5)C
Alternate CAS	1293281-49-8
PubChem CID	67116280
MeSH Entry Terms	((3aR,6aS)-5-(4,6-Dimethyl-2-pyrimidinyl)hexahydropyrrolo(3,4-c)pyrrol-2(1H)-yl)(2-fluoro-6-(2H-1,2,3-triazol-2-yl)phenyl)methanone;JNJ-42847922;Methanone, ((3aR,6aS)-5-(4,6-dimethyl-2-pyrimidinyl)hexahydropyrrolo(3,4-c)pyrrol-2(1H)-yl)(2-fluoro-6-(2H-1,2
Molecular Weight	407.44

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

Find and download the COA for your product by matching the lot number on the packaging.

12 results found

Lot Number	Certificate Type	Date	Item
C2412473	Certificate of Analysis	Jan 25, 2024	S412988
C2412474	Certificate of Analysis	Jan 25, 2024	S412988
C2412475	Certificate of Analysis	Jan 25, 2024	S412988
C2412476	Certificate of Analysis	Jan 25, 2024	S412988
C2412477	Certificate of Analysis	Jan 25, 2024	S412988
C2412478	Certificate of Analysis	Jan 25, 2024	S412988
C2412479	Certificate of Analysis	Jan 25, 2024	S412988
C2412480	Certificate of Analysis	Jan 25, 2024	S412988
C2412481	Certificate of Analysis	Jan 25, 2024	S412988
C2412482	Certificate of Analysis	Jan 25, 2024	S412988
C2412483	Certificate of Analysis	Jan 25, 2024	S412988
C2412484	Certificate of Analysis	Jan 25, 2024	S412988

Show more⌵

Safety and Hazards(GHS)

Pictogram(s)	GHS06, GHS07
Signal	Danger
Hazard Statements	H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation H301:Toxic if swallowed H312:Harmful in contact with skin H332:Harmful if inhaled
Precautionary Statements	P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P271:Use only outdoors or in a well-ventilated area. P270:Do not eat, drink or smoke when using this product. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P362+P364:Take off contaminated clothing and wash it before reuse. P330:Rinse mouth. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P301+P316:IF SWALLOWED: Get emergency medical help immediately. P317:Get emergency medical help. P337+P317:If eye irritation persists: Get medical help. P332+P317:If skin irritation occurs: Get medical help. P319:Get medical help if you feel unwell.

References

1. Bonaventure P, Shelton J, Yun S, Nepomuceno D, Sutton S, Aluisio L, Fraser I, Lord B, Shoblock J, Welty N et al.. (2015) Characterization of JNJ-42847922, a Selective Orexin-2 Receptor Antagonist, as a Clinical Candidate for the Treatment of Insomnia.. J Pharmacol Exp Ther, 354 (3): (471-82). [PMID:26177655] [10.1021/op500134e]

Solution Calculators

Molarity Calculator

Determine the necessary mass, volume, or concentration for preparing a solution.

Dilution Calculator

Determine the dilution needed to prepare a stock solution.