Senktide, CAS No.106128-89-6, Agonist of NK 3 receptor

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    Item Number
    S288372
    Grouped product items
    SKUSizeAvailabilityPrice Qty
    S288372-500μg
    500μg
    Available within 8-12 weeks(?)
    Production requires sourcing of materials. We appreciate your patience and understanding.
    $444.90
    S288372-1mg
    1mg
    Available within 8-12 weeks(?)
    Production requires sourcing of materials. We appreciate your patience and understanding.
    $54.90
    S288372-5mg
    5mg
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    Production requires sourcing of materials. We appreciate your patience and understanding.
    $126.90
    S288372-10mg
    10mg
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    Production requires sourcing of materials. We appreciate your patience and understanding.
    $188.90

    Tachykinin NK3agonist

    View related series
    NK3 receptor Agonist

    Basic Description

    Product NameSenktide, CAS No.106128-89-6
    SynonymsSenktide | 106128-89-6 | CHEMBL106124 | (5S,8S,14S,17S,20S)-14,17-Dibenzyl-5-carbamoyl-20-(carboxymethyl)-8-isobutyl-15-methyl-7,10,13,16,19,22-hexaoxo-2-thia-6,9,12,15,18,21-hexaazapentacosan-25-oic acid | Succinyl-6-asp-8-Me-phe-substance P (6-11) | Substance P (
    GradeMoligand™
    Specifications & PurityMoligand™, ≥98%
    Biochemical and Physiological MechanismsNK3tachykinin receptor agonist. Causes direct excitation of dopamine neurons; enhances dopaminergic function. Induces locomotor activity.
    SequenceDFFGLM(Modifications: Asp-1 = Succinyl-Asp, Phe-3 = Me-Phe, Met-6 = C-terminal amide)
    Action TypeAGONIST
    Mechanism of actionAgonist of NK 3 receptor
    Note卖完停产,不再备货

    Associated Targets(Human)

    TACR3 Tchem Neuromedin-K receptor (10 Activities)
    Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
    ABL1 Tclin Tyrosine-protein kinase ABL (18331 Activities)
    Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
    ADRB2 Tclin Beta-2 adrenergic receptor (11824 Activities)
    Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
    ADRA2A Tclin Alpha-2a adrenergic receptor (9450 Activities)
    Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
    AGTR1 Tclin Type-1 angiotensin II receptor (5176 Activities)
    Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
    MME Tclin Neprilysin (838 Activities)
    Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
    TACR1 Tclin Neurokinin 1 receptor (6273 Activities)
    Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
    TACR2 Tchem Neurokinin 2 receptor (3341 Activities)
    Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
    GSK3B Tclin Glycogen synthase kinase-3 beta (11785 Activities)
    Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
    CSNK1D Tchem Casein kinase I delta (4546 Activities)
    Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
    TACR3 Tchem Neurokinin 3 receptor (1696 Activities)
    Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
    S1PR1 Tclin Sphingosine 1-phosphate receptor Edg-1 (5806 Activities)
    Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
    CDK2 Tchem Cyclin-dependent kinase 2 (9050 Activities)
    Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
    GLP1R Tclin Glucagon-like peptide 1 receptor (111429 Activities)
    Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
    C5AR1 Tclin C5a anaphylatoxin chemotactic receptor (2677 Activities)
    Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
    AURKA Tchem Serine/threonine-protein kinase Aurora-A (10240 Activities)
    Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
    U2OS (164939 Activities)
    Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
    CX3CR1 Tchem C-X3-C chemokine receptor 1 (1686 Activities)
    Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
    FPR2 Tchem Lipoxin A4 receptor (3472 Activities)
    Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
    FFAR4 Tchem G-protein coupled receptor 120 (2999 Activities)
    Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
    BRD4 Tchem Bromodomain-containing protein 4 (13122 Activities)
    Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
    GPR35 Tchem G-protein coupled receptor 35 (2643 Activities)
    Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
    TRIM24 Tchem Transcription intermediary factor 1-alpha (2087 Activities)
    Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
    BRPF1 Tchem Peregrin (2217 Activities)
    Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
    HEK-293T (167025 Activities)
    Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
    ADGRF1 Tbio Adhesion G-protein coupled receptor F1 (1591 Activities)
    Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

    Associated Targets(non-human)

    Aplnr Apelin receptor (201 Activities)
    Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
    Mapk1 MAP kinase ERK2 (650 Activities)
    Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
    Fgfr3 Fibroblast growth factor receptor 3 (21 Activities)
    Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
    Gpr119 Glucose-dependent insulinotropic receptor (270 Activities)
    Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
    Serum (58 Activities)
    Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
    TACR3 NK-3 receptor (9 Activities)
    Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

    Product Specifications

    Storage TempProtected from light,Store at -20°C,Desiccated
    Shipped InIce chest + Ice pads
    CAS106128-89-6

    Certificates

    Certificate of Analysis(COA)

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    8 results found

    Lot NumberCertificate TypeDateItem
    A2422345Certificate of AnalysisDec 19, 2023 S288372
    A2422351Certificate of AnalysisDec 19, 2023 S288372
    A2422352Certificate of AnalysisDec 19, 2023 S288372
    A2422353Certificate of AnalysisDec 19, 2023 S288372
    A2422354Certificate of AnalysisDec 19, 2023 S288372
    A2422355Certificate of AnalysisDec 19, 2023 S288372
    A2422356Certificate of AnalysisDec 19, 2023 S288372
    A2422357Certificate of AnalysisDec 19, 2023 S288372

    Safety and Hazards(GHS)

    WGK Germany 3
    RIDADR NONHforallmodesoftransport

    Genetic information

    Alternate NamesSenktide|106128-89-6|CHEMBL106124|(5S,8S,14S,17S,20S)-14,17-Dibenzyl-5-carbamoyl-20-(carboxymethyl)-8-isobutyl-15-methyl-7,10,13,16,19,22-hexaoxo-2-thia-6,9,12,15,18,21-hexaazapentacosan-25-oic acid|Succinyl-6-asp-8-Me-phe-substance P (6-11)|Substance P (
    Reference
    • 1. Kinetics and inhibition of recombinant human cystathionine gamma-lyase. Toward the rational control of transsulfuration., The Journal of biological chemistry, Steegborn, C C and 7 more authors.
    • 2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences., Proceedings of the National Academy of Sciences of the United States of America, Strausberg, Robert L RL and 83 more authors.
    • 3. Genomic basis of cystathioninuria (MIM 219500) revealed by multiple mutations in cystathionine gamma-lyase (CTH)., Human genetics, Wang, Jian J and Hegele, Robert A RA.
    • 4. Cloning and nucleotide sequence of human liver cDNA encoding for cystathionine gamma-lyase., Biochemical and biophysical research communications, Lu, Y Y, O'Dowd, B F BF, Orrego, H H and Israel, Y Y.
    • 5. Single nucleotide polymorphism in CTH associated with variation in plasma homocysteine concentration., Clinical genetics, Wang, J J, Huff, A M AM, Spence, J D JD and Hegele, R A RA.
    • 6. Cystathionine gamma-lyase overexpression inhibits cell proliferation via a H2S-dependent modulation of ERK1/2 phosphorylation and p21Cip/WAK-1., The Journal of biological chemistry, Yang, Guangdong G, Cao, Kun K, Wu, Lingyun L and Wang, Rui R.
    • 7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)., Genome research, Gerhard, Daniela S DS and 115 more authors.
    • 8. Towards a proteome-scale map of the human protein-protein interaction network., Nature, Rual, Jean-François JF and 37 more authors.
    • 9. The DNA sequence and biological annotation of human chromosome 1., Nature, Gregory, S G SG and 178 more authors.
    • 10. Polymorphisms in one-carbon metabolism and trans-sulfuration pathway genes and susceptibility to bladder cancer., International journal of cancer, Moore, Lee E LE and 14 more authors. more

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