Determine the necessary mass, volume, or concentration for preparing a solution.
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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S111161-1g | 1g | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $46.90 | |
S111161-5g | 5g | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $177.90 | |
S111161-25g | 25g | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $812.90 |
Endogenous neurotransmitter, 5-HT receptor agonist
Synonyms | Serotonin hydrochloride | 153-98-0 | 5-Hydroxytryptamine hydrochloride | Serotonin HCl | 3-(2-aminoethyl)-1H-indol-5-ol hydrochloride | 1H-Indol-5-ol, 3-(2-aminoethyl)-, monohydrochloride | CCRIS 4420 | UNII-GKN429M9VS | GKN429M9VS | 5-HT hydrochloride | 3-(2-aminoethyl)-1H- |
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Specifications & Purity | AR |
Biochemical and Physiological Mechanisms | Endogenous 5-HT receptor agonist. Neurotransmitter involved in diverse physiological functions such as mood, appetite, sleep, sex and temperature in addition to modulating cardiovascular function and the gastrointestinal system. |
Storage Temp | Store at -20°C,Argon charged |
Shipped In | Ice chest + Ice pads |
Grade | AR |
Note | Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details. |
Product Description | Serotonin hydrochloride is the salt form of Serotonin, a monoamine neurotransmitter biochemically derived from tryptophan. This neurotransmitter is located in the central nervous system and functions as an endogenous SR (serotonin receptor) agonist in a variety of biochemical processes. In the majority of the human bodies, serotonin is located in enterochromaffin (”Kulchitsky cells”). Serotonin is found in the gastrointestinal tract and platelets. Furthermore, Serotonin functions as a growth factor in some cells and facilitates wound healing in conjunction with platelets. Serotonin is thought to be a key component in the regulation of moods, cognition, and personality traits. As a result, this compound is essential in studying the variations in these traits. |
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IUPAC Name | 3-(2-aminoethyl)-1H-indol-5-ol;hydrochloride |
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INCHI | InChI=1S/C10H12N2O.ClH/c11-4-3-7-6-12-10-2-1-8(13)5-9(7)10;/h1-2,5-6,12-13H,3-4,11H2;1H |
InChi Key | MDIGAZPGKJFIAH-UHFFFAOYSA-N |
Canonical SMILES | C1=CC2=C(C=C1O)C(=CN2)CCN.Cl |
Isomeric SMILES | C1=CC2=C(C=C1O)C(=CN2)CCN.Cl |
WGK Germany | 3 |
RTECS | NM2571000 |
PubChem CID | 160436 |
UN Number | 2811 |
Molecular Weight | 212.68 |
Beilstein | 3570963 |
Reaxy-Rn | 3570963 |
Enter Lot Number to search for COA:
To view the certificate results,please click on a Lot number.For Lot numbers from past orders,please use our order status section
Lot Number | Certificate Type | Date | Item |
---|---|---|---|
J2323691 | Certificate of Analysis | Oct 07, 2023 | S111161 |
J2323692 | Certificate of Analysis | Oct 07, 2023 | S111161 |
J2323714 | Certificate of Analysis | Oct 07, 2023 | S111161 |
E2326312 | Certificate of Analysis | Jun 13, 2022 | S111161 |
H2217678 | Certificate of Analysis | Jun 13, 2022 | S111161 |
H2217679 | Certificate of Analysis | Jun 13, 2022 | S111161 |
Solubility | Soluble in water (17 mg/ml), methanol, ethanol (5.3 mg/ml), 0.1 M HCl (22 mg/ml), aqueous acid, and DMSO (100 mM). Insoluble in chloroform, and ether. |
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Sensitivity | Moisture & Light sensitive |
Melt Point(°C) | 168-172°C |
Pictogram(s) | GHS06, GHS07 |
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Signal | Danger |
Hazard Statements | H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation H301:Toxic if swallowed H302:Harmful if swallowed H312:Harmful in contact with skin H332:Harmful if inhaled |
Precautionary Statements | P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P271:Use only outdoors or in a well-ventilated area. P270:Do not eat, drink or smoke when using this product. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P362+P364:Take off contaminated clothing and wash it before reuse. P330:Rinse mouth. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P301+P316:IF SWALLOWED: Get emergency medical help immediately. P301+P317:IF SWALLOWED: Get medical help. P317:Get emergency medical help. P337+P317:If eye irritation persists: Get medical help. P332+P317:If skin irritation occurs: Get medical help. P319:Get medical help if you feel unwell. |
WGK Germany | 3 |
RTECS | NM2571000 |
Reaxy-Rn | 3570963 |
Merck Index | 8462 |
Starting at $152.90
1. Wenlin Ma, Lihua Pang, Jinhua Liu, Lei Wen, Huili Ma, Yinhui Li, Zhihui Xu, Chengwu Zhang, Hai-Dong Yu. (2023) MnO4–-Triggered Immediate-Stable Real-Time Fluorescence Immunosensor with High Response Speed and Low Steady-State Error. ANALYTICAL CHEMISTRY, 95 (15): (6323–6331). [PMID:37018486] |
2. Jiang Mengyuan, Tian Liang, Su Mengjie, Cao Xiaoqing, Jiang Qiyu, Huo Xiaolei, Yu Chunmei. (2022) Real-time monitoring of 5-HT release from cells based on MXene hybrid single-walled carbon nanotubes modified electrode. ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 414 (28): (7967-7976). [PMID:36129526] |
3. Yao Wang,Wentao Zhu,Jing Qiu,Xinru Wang,Ping Zhang,Jin Yan,Zhiqiang Zhou. (2015-04-13) Monitoring tryptophan metabolism after exposure to hexaconazole and the enantioselective metabolism of hexaconazole in rat hepatocytes in vitro.. Journal of hazardous materials, 295 (9-16). [PMID:25863579] |
4. Jian-Jun Zhong,Ningbo Liao,Tian Ding,Xingqian Ye,Dong-Hong Liu. (2015-07-05) Liquid chromatographic method for toxic biogenic amines in foods using a chaotropic salt.. Journal of chromatography. A, 1406 (331-336). [PMID:26141272] |
1. Lim I et al.. (2018) Altered ureteral contractility with ageing: Role of the rho-kinase pathway.. Mech Ageing Dev, 171 (31-36). [PMID:29530787] |
2. Foster JD et al.. (2014) Nitric oxide-mediated modulation of the murine locomotor network.. J Neurophysiol, 111 (3): (659-74). [PMID:24259545] |
3. Wenlin Ma, Lihua Pang, Jinhua Liu, Lei Wen, Huili Ma, Yinhui Li, Zhihui Xu, Chengwu Zhang, Hai-Dong Yu. (2023) MnO4–-Triggered Immediate-Stable Real-Time Fluorescence Immunosensor with High Response Speed and Low Steady-State Error. ANALYTICAL CHEMISTRY, 95 (15): (6323–6331). [PMID:37018486] |
4. Jiang Mengyuan, Tian Liang, Su Mengjie, Cao Xiaoqing, Jiang Qiyu, Huo Xiaolei, Yu Chunmei. (2022) Real-time monitoring of 5-HT release from cells based on MXene hybrid single-walled carbon nanotubes modified electrode. ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 414 (28): (7967-7976). [PMID:36129526] |
5. Yao Wang,Wentao Zhu,Jing Qiu,Xinru Wang,Ping Zhang,Jin Yan,Zhiqiang Zhou. (2015-04-13) Monitoring tryptophan metabolism after exposure to hexaconazole and the enantioselective metabolism of hexaconazole in rat hepatocytes in vitro.. Journal of hazardous materials, 295 (9-16). [PMID:25863579] |
6. Jian-Jun Zhong,Ningbo Liao,Tian Ding,Xingqian Ye,Dong-Hong Liu. (2015-07-05) Liquid chromatographic method for toxic biogenic amines in foods using a chaotropic salt.. Journal of chromatography. A, 1406 (331-336). [PMID:26141272] |