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Sertindole - 95%, high purity , Serotonin 2 receptors; 5-HT2a & 5-HT2c antagonist, CAS No.106516-24-9, Serotonin 2 receptors; 5-HT2a & 5-HT2c antagonist
Basic Description Synonyms SERTINDOLE|106516-24-9|SerLect|Serdolect|Sertindol|Lu 23-174|Sertindolum|Sertindol [INN-Spanish]|Sertindolum [INN-Latin]|zerdol|Lu-23-174|1-[2-[4-[5-chloro-1-(4-fluorophenyl)indol-3-yl]piperidin-1-yl]ethyl]imidazolidin-2-one|1-(2-{4-[5-chloro-1-(4-fluorop Specifications & Purity Moligand™, ≥95% Biochemical and Physiological Mechanisms Sertindole readily passes the blood-brain barrier and is metabolized into compounds that show greater affinity for 5-HT2 receptors and less for D2 receptors. It is an effective treatment agent for schizophrenia as it improves cognitive impairment.1 Sertin Storage Temp Store at -20°C Shipped In Ice chest + Ice pads Grade Moligand™ Action Type ANTAGONIST Mechanism of action Serotonin 2 receptors; 5-HT2a & 5-HT2c antagonist Product Description Sertindole was used to study the role of 5-HT2C receptor in antipsychotic-induced body weight gain in rats.
Names and Identifiers IUPAC Name 1-[2-[4-[5-chloro-1-(4-fluorophenyl)indol-3-yl]piperidin-1-yl]ethyl]imidazolidin-2-one INCHI InChI=1S/C24H26ClFN4O/c25-18-1-6-23-21(15-18)22(16-30(23)20-4-2-19(26)3-5-20)17-7-10-28(11-8-17)13-14-29-12-9-27-24(29)31/h1-6,15-17H,7-14H2,(H,27,31) InChi Key GZKLJWGUPQBVJQ-UHFFFAOYSA-N Canonical SMILES C1CN(CCC1C2=CN(C3=C2C=C(C=C3)Cl)C4=CC=C(C=C4)F)CCN5CCNC5=O Isomeric SMILES C1CN(CCC1C2=CN(C3=C2C=C(C=C3)Cl)C4=CC=C(C=C4)F)CCN5CCNC5=O WGK Germany 3 RTECS NJ0621100 PubChem CID 60149 Molecular Weight 440.9 Reaxy-Rn 5364890
Chemical and Physical Properties Solubility DMSO: >10 mg/mL；H2O: <2 mg/mL Sensitivity heat sensitive Melt Point(°C) 155°C(lit.)
Safety and Hazards(GHS) Pictogram(s) GHS07 Signal Warning Hazard Statements H315: Causes skin irritation
H319: Causes serious eye irritation
H335: May cause respiratory irritation
H413: May cause long lasting harmful effects to aquatic life
Precautionary Statements P261: Avoid breathing dust/fume/gas/mist/vapors/spray.
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing.
P273: Avoid release to the environment.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352: IF ON SKIN: wash with plenty of water.
P321: Specific treatment (see ... on this label).
P405: Store locked up.
P501: Dispose of contents/container to ...
P264: Wash hands [and …] thoroughly after handling.
P271: Use only outdoors or in a well-ventilated area.
P304+P340: IF INHALED: Remove person to fresh air and keep comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P362+P364: Take off contaminated clothing and wash it before reuse.
P264+P265: Wash hands [and …] thoroughly after handling. Do not touch eyes.
P337+P317: If eye irritation persists: Get medical help.
P332+P317: If skin irritation occurs: Get medical help.
P319: Get medical help if you feel unwell.
WGK Germany 3 RTECS NJ0621100 Reaxy-Rn 5364890 Merck Index 8466
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