Basic Description

Synonyms	TRPV2 antagonist SET2 \| N-(Furan-2-ylmethyl)-3-((4-(methyl(propyl)amino)-6-(trifluoromethyl)pyrimidin-2-yl)thio)propanamide \| AKOS040755628 \| HY-132222 \| DTXSID101336558 \| GTPL12547 \| 2313525-20-9 \| N-(Furan-2-ylmethyl)-3-(4-(methyl(propyl)amino)-6-(trifl
Specifications & Purity	Moligand™, ≥98%(HPLC)
Biochemical and Physiological Mechanisms	TRPV2 (transient receptor potential vanilloid type 2) antagonist (IC50= 0.46 μM). Selective for TRPV2 over TRPV1, TRPV3 and TRPV4 expressed in HEK293 cells. Inhibits lyosphosphatidic acid (LPA)-induced prostate cancer cell migrationin vitro.
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Grade	Moligand™
Action Type	CHANNEL BLOCKER
Mechanism of action	Channel blocker of TRPV2

Associated Targets(Human)

TRPV2 Tchem Transient receptor potential cation channel subfamily V member 2 (0 Activities)

Discover Target: TRPV2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

TRPV4 Tchem Transient receptor potential cation channel subfamily V member 4 (774 Activities)

Discover Target: TRPV4

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

TRPV3 Tchem Transient receptor potential cation channel subfamily V member 3 (542 Activities)

Discover Target: TRPV3

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Associated Targets(non-human)

Trpv2 Transient receptor potential cation channel subfamily V member 2 (148 Activities)

Discover Target: Trpv2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Trpv1 Transient receptor potential cation channel subfamily V member 1 (45 Activities)

Discover Target: Trpv1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

Pubchem Sid	488203091
Pubchem Sid Url	https://pubchem.ncbi.nlm.nih.gov/substance/488203091
IUPAC Name	N-(furan-2-ylmethyl)-3-[4-[methyl(propyl)amino]-6-(trifluoromethyl)pyrimidin-2-yl]sulfanylpropanamide
INCHI	InChI=1S/C17H21F3N4O2S/c1-3-7-24(2)14-10-13(17(18,19)20)22-16(23-14)27-9-6-15(25)21-11-12-5-4-8-26-12/h4-5,8,10H,3,6-7,9,11H2,1-2H3,(H,21,25)
InChi Key	LZHSWRWIMQRTOP-UHFFFAOYSA-N
Canonical SMILES	CCCN(C)C1=NC(=NC(=C1)C(F)(F)F)SCCC(=O)NCC2=CC=CO2
Isomeric SMILES	CCCN(C)C1=NC(=NC(=C1)C(F)(F)F)SCCC(=O)NCC2=CC=CO2
PubChem CID	155541857
Molecular Weight	402.44

Database links

PubChem CID	155541857
ChEMBL Ligand	CHEMBL4519204
CAS Registry No.	2313525-20-9
PubChem SID	488203091

Certificates

Certificate of Analysis(COA)

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10 results found

Lot Number	Certificate Type	Date	Item
D2307772	Certificate of Analysis	Feb 20, 2023	S287626
D2307773	Certificate of Analysis	Feb 20, 2023	S287626
D2307779	Certificate of Analysis	Feb 20, 2023	S287626
D2307780	Certificate of Analysis	Feb 20, 2023	S287626
D2307857	Certificate of Analysis	Feb 20, 2023	S287626
D2307858	Certificate of Analysis	Feb 20, 2023	S287626
D2307868	Certificate of Analysis	Feb 20, 2023	S287626
D2307869	Certificate of Analysis	Feb 20, 2023	S287626
D2307870	Certificate of Analysis	Feb 20, 2023	S287626
D2307874	Certificate of Analysis	Feb 20, 2023	S287626

Chemical and Physical Properties

Solubility	Solvent:DMSO, Max Conc. mg/mL: 40.24, Max Conc. mM: 100; Solvent:ethanol, Max Conc. mg/mL: 20.12, Max Conc. mM: 50

References

1. Chai H, Cheng X, Zhou B, Zhao L, Lin X, Huang D, Lu W, Lv H, Tang F, Zhang Q et al.. (2019) Structure-Based Discovery of a Subtype-Selective Inhibitor Targeting a Transient Receptor Potential Vanilloid Channel.. J Med Chem, 62 (3): (1373-1384). [PMID:30620187] [10.1021/op500134e]

Solution Calculators

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SKU	Size	Availability	Price
S287626-5mg	5mg	In stock	$107.90
S287626-10mg	10mg	In stock	$177.90
S287626-25mg	25mg	In stock	$375.90
S287626-50mg	50mg	In stock	$632.90
S287626-100mg	100mg	In stock	$1,038.90

SET 2 - ≥98%(HPLC), high purity , CAS No.2313525-20-9, Channel blocker of TRPV2