sFRP-1 Inhibitor inhibitor - ≥95%, high purity , CAS No.915754-88-0

Item Number

S334427

Grouped product items
SKU	Size	Availability	Price	Qty
S334427-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$209.90

a selective and reversible inhibitor of sFRP-1

Basic Description

Synonyms	sFRP-1 Inhibitor \| 915754-88-0 \| CHEMBL473916 \| 5-(benzenesulfonyl)-N-[3-(dimethylamino)propyl]-2-ethylbenzenesulfonamide \| SCHEMBL4616141 \| DTXSID90648874 \| BDBM50246616 \| PD015729 \| N-[3-(Dimethylamino)propyl]-2-ethyl-5-(phenylsulfonyl)benzenesulfonamide \| 5-(Benzenesulf
Specifications & Purity	≥95%
Storage Temp	Store at 2-8°C
Shipped In	Wet ice
Note	Store as supplied at 4° C.Following reconstitution, aliquot and freeze at -20° C.Stock solutions are stable for up to 6 months at -20° C.
Product Description	sFRP-1 Inhibitor is a cell-permeable diphenylsulfone-sulfonamide compound that acts as a selective and reversible inhibitor of sFRP-1, and potently activates canonical Wnt pathway. Shows a desirable aqueous solubility and\|in-vitro\|microsomal stability-human. Marginally affects cytochrome p450 isozymes.

Associated Targets(Human)

CYP2D6 Tclin Cytochrome P450 2D6 (33882 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CYP2C9 Tchem Cytochrome P450 2C9 (32119 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CYP3A4 Tclin Cytochrome P450 3A4 (53859 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

SFRP1 Tchem Secreted frizzled-related protein 1 (240 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Names and Identifiers

IUPAC Name	5-(benzenesulfonyl)-N-[3-(dimethylamino)propyl]-2-ethylbenzenesulfonamide
INCHI	InChI=1S/C19H26N2O4S2/c1-4-16-11-12-18(26(22,23)17-9-6-5-7-10-17)15-19(16)27(24,25)20-13-8-14-21(2)3/h5-7,9-12,15,20H,4,8,13-14H2,1-3H3
InChi Key	BHFFSIFXFHJJNJ-UHFFFAOYSA-N
Canonical SMILES	CCC1=C(C=C(C=C1)S(=O)(=O)C2=CC=CC=C2)S(=O)(=O)NCCCN(C)C
Isomeric SMILES	CCC1=C(C=C(C=C1)S(=O)(=O)C2=CC=CC=C2)S(=O)(=O)NCCCN(C)C
PubChem CID	25147677
Molecular Weight	410.55

Solubility

Soluble in water (26 μg/ml) at pH 7.4, and DMSO (5 mg/ml).

Refractive Index

n20D1.57

Boil Point(°C)

586.88° C at 760 mmHg (Predicted)

Solution Calculators

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Basic Description