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SKU | Size | Availability | Price | Qty |
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S651632-1mg | 1mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $166.90 | |
S651632-5mg | 5mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $350.90 | |
S651632-10mg | 10mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $550.90 | |
S651632-25mg | 25mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $950.90 | |
S651632-50mg | 50mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $1,450.90 | |
S651632-100mg | 100mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $2,250.90 |
Specifications & Purity | ≥99% |
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Biochemical and Physiological Mechanisms | SHIP2-IN-1 is a potent SHIP2 inhibitor, inhibits SHIP2 activity, with an IC 50 of 2 µM. SHIP2-IN-1 blocks GSK3β activation by phosphorylation at the Ser9 residue. SHIP2-IN-1 is used in the research of Alzheimer’s disease. |
Storage Temp | Store at -20°C |
Shipped In | Ice chest + Ice pads |
Product Description | SHIP2-IN-1 is a potent SHIP2 inhibitor, inhibits SHIP2 activity, with an IC 50 of 2 µM. SHIP2-IN-1 blocks GSK3β activation by phosphorylation at the Ser9 residue. SHIP2-IN-1 is used in the research of Alzheimer’s disease In Vitro SHIP2-IN-1 (Compound 43; 10 µM) significantly inhibits PI(3,4)P2 production in HT22 cells. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:IC50: 2 µM (SHIP2) |
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IUPAC Name | 5-[5-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]pyridin-3-yl]pyrimidin-2-amine |
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INCHI | InChI=1S/C17H13Cl2FN4O/c1-9(15-13(18)2-3-14(20)16(15)19)25-12-4-10(5-22-8-12)11-6-23-17(21)24-7-11/h2-9H,1H3,(H2,21,23,24)/t9-/m1/s1 |
InChi Key | ATPYDXUUBCDYKQ-SECBINFHSA-N |
Canonical SMILES | CC(C1=C(C=CC(=C1Cl)F)Cl)OC2=CN=CC(=C2)C3=CN=C(N=C3)N |
Isomeric SMILES | C[C@H](C1=C(C=CC(=C1Cl)F)Cl)OC2=CN=CC(=C2)C3=CN=C(N=C3)N |
PubChem CID | 138319691 |
Molecular Weight | 379.2 |
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Solubility | DMSO : 100 mg/mL (263.70 mM; Need ultrasonic) |
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