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SHP099 - 10mM in DMSO, high purity , CAS No.1801747-42-1(DMSO)
Basic Description
| Specifications & Purity | 10mM in DMSO |
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| Storage Temp | Store at -80°C |
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| Shipped In | Ice chest + Ice pads |
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| Product Description | General description：
SHP099 is a highly potent, selective small-molecule SHP2 inhibitor with an IC50 value of 71 nM and shows no activity against SHP1. |
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Associated Targets(Human)
Associated Targets(non-human)
Mechanisms of Action
| Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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Names and Identifiers
| IUPAC Name | 6-(4-amino-4-methylpiperidin-1-yl)-3-(2,3-dichlorophenyl)pyrazin-2-amine |
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| INCHI | InChI=1S/C16H19Cl2N5/c1-16(20)5-7-23(8-6-16)12-9-21-14(15(19)22-12)10-3-2-4-11(17)13(10)18/h2-4,9H,5-8,20H2,1H3,(H2,19,22) |
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| InChi Key | YGUFCDOEKKVKJK-UHFFFAOYSA-N |
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| Canonical SMILES | CC1(CCN(CC1)C2=CN=C(C(=N2)N)C3=C(C(=CC=C3)Cl)Cl)N |
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| Isomeric SMILES | CC1(CCN(CC1)C2=CN=C(C(=N2)N)C3=C(C(=CC=C3)Cl)Cl)N |
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| PubChem CID | 118238298 |
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| Molecular Weight | 352.26 |
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Chemical and Physical Properties
| Solubility | Insoluble in water and ethanol;70 mg/mL (198.72 mM)in DMSO |
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| Sensitivity | Moisture sensitive. |
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Safety and Hazards(GHS)
| Pictogram(s) | GHS07 |
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| Signal | Warning |
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| Hazard Statements | H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation H302:Harmful if swallowed |
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| Precautionary Statements | P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. |
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