SHU9119,TFA - ≥95%, high purity , CAS No.168482-23-3(free base), Agonist of MC 1 receptor;Antagonist of MC 3 receptor;Antagonist of MC 4 receptor;Agonist of MC 5 receptor

Item Number
S275436
Grouped product items
SKUSizeAvailabilityPrice Qty
S275436-1mg
1mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$84.90
S275436-5mg
5mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$338.90
S275436-10mg
10mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$541.90
S275436-25mg
25mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$948.90
S275436-50mg
50mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$1,517.90

Potent melanocortin 3 and 4 (MC 3 and MC 4 ) receptor antagonist

Basic Description

Specifications & PurityMoligand™, ≥95%
Biochemical and Physiological MechanismsPotent melanocortin 3 and 4 (MC 3 and MC 4 ) receptor antagonist (IC 50 values are 0.23 and 0.06 nM, respectively). Also shows MC 5 partial agonist activity (EC 50 = 0.12 nM). Dose-dependently increases food intake following central administration.
Storage TempStore at -20°C,Desiccated
Shipped InIce chest + Ice pads
GradeMoligand™
Action TypeAGONIST, ANTAGONIST
Mechanism of actionAgonist of MC 1 receptor;Antagonist of MC 3 receptor;Antagonist of MC 4 receptor;Agonist of MC 5 receptor

Associated Targets(Human)

MC5R Tchem Melanocortin receptor 5 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
MC4R Tclin Melanocortin receptor 4 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
MC3R Tchem Melanocortin receptor 3 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
MC1R Tclin Melanocyte-stimulating hormone receptor (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

Names and Identifiers

Molecular Weight 1074.25(free base)

Certificates

Certificate of Analysis(COA)

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10 results found

Lot NumberCertificate TypeDateItem
C2425471Certificate of AnalysisJan 30, 2024 S275436
C2425472Certificate of AnalysisJan 30, 2024 S275436
C2425473Certificate of AnalysisJan 30, 2024 S275436
C2425474Certificate of AnalysisJan 30, 2024 S275436
C2425475Certificate of AnalysisJan 30, 2024 S275436
C2425491Certificate of AnalysisJan 30, 2024 S275436
C2425492Certificate of AnalysisJan 30, 2024 S275436
C2425502Certificate of AnalysisJan 30, 2024 S275436
C2425503Certificate of AnalysisJan 30, 2024 S275436
C2425504Certificate of AnalysisJan 30, 2024 S275436

Chemical and Physical Properties

SolubilitySoluble in water

Related Documents

References

1. Kabra DG et al..  (2016)  Hypothalamic leptin action is mediated by histone deacetylase 5..  Nat Commun,  (10782).  [PMID:26923837]
2. Bruschetta G et al..  (2020)  MC4R Signaling in Dorsal Raphe Nucleus Controls Feeding, Anxiety, and Depression..  Cell Rep,  33  (2): (108267).  [PMID:33053350]
3. Martins CA et al..  (2020)  Neuroprotective effect of ACTH on collagenase-induced peri-intraventricular hemorrhage in newborn male rats..  Sci Rep,  10  (17734).  [PMID:33082383]

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