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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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S275436-1mg | 1mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $84.90 | |
S275436-5mg | 5mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $338.90 | |
S275436-10mg | 10mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $541.90 | |
S275436-25mg | 25mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $948.90 | |
S275436-50mg | 50mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $1,517.90 |
Potent melanocortin 3 and 4 (MC 3 and MC 4 ) receptor antagonist
Specifications & Purity | Moligand™, ≥95% |
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Biochemical and Physiological Mechanisms | Potent melanocortin 3 and 4 (MC 3 and MC 4 ) receptor antagonist (IC 50 values are 0.23 and 0.06 nM, respectively). Also shows MC 5 partial agonist activity (EC 50 = 0.12 nM). Dose-dependently increases food intake following central administration. |
Storage Temp | Store at -20°C,Desiccated |
Shipped In | Ice chest + Ice pads |
Grade | Moligand™ |
Action Type | AGONIST, ANTAGONIST |
Mechanism of action | Agonist of MC 1 receptor;Antagonist of MC 3 receptor;Antagonist of MC 4 receptor;Agonist of MC 5 receptor |
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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Molecular Weight | 1074.25(free base) |
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PubChem CID | 6440621 |
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CAS Registry No. | 168482-23-3 |
GPCRdb Ligand | SHU9119 |
Enter Lot Number to search for COA:
Find and download the COA for your product by matching the lot number on the packaging.
Lot Number | Certificate Type | Date | Item |
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C2425471 | Certificate of Analysis | Jan 30, 2024 | S275436 |
C2425472 | Certificate of Analysis | Jan 30, 2024 | S275436 |
C2425473 | Certificate of Analysis | Jan 30, 2024 | S275436 |
C2425474 | Certificate of Analysis | Jan 30, 2024 | S275436 |
C2425475 | Certificate of Analysis | Jan 30, 2024 | S275436 |
C2425491 | Certificate of Analysis | Jan 30, 2024 | S275436 |
C2425492 | Certificate of Analysis | Jan 30, 2024 | S275436 |
C2425502 | Certificate of Analysis | Jan 30, 2024 | S275436 |
C2425503 | Certificate of Analysis | Jan 30, 2024 | S275436 |
C2425504 | Certificate of Analysis | Jan 30, 2024 | S275436 |
Solubility | Soluble in water |
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1. Kabra DG et al.. (2016) Hypothalamic leptin action is mediated by histone deacetylase 5.. Nat Commun, 7 (10782). [PMID:26923837] |
2. Bruschetta G et al.. (2020) MC4R Signaling in Dorsal Raphe Nucleus Controls Feeding, Anxiety, and Depression.. Cell Rep, 33 (2): (108267). [PMID:33053350] |
3. Martins CA et al.. (2020) Neuroprotective effect of ACTH on collagenase-induced peri-intraventricular hemorrhage in newborn male rats.. Sci Rep, 10 (17734). [PMID:33082383] |