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SIB 1757 - 98%, high purity , CAS No.31993-01-8, Allosteric modulator of mGlu 5 receptor

Item Number
S287942
Grouped product items
SKUSizeAvailabilityPrice Qty
S287942-5mg
5mg
In stock
$53.90
S287942-10mg
10mg
In stock
$81.90
S287942-25mg
25mg
In stock
$183.90
S287942-50mg
50mg
In stock
$342.90
S287942-100mg
100mg
In stock
$615.90

Highly selective mGlu5antagonist

Basic Description

SynonymsNCGC00185991-01 | CHEBI:93722 | SR-01000076142-1 | BCP33033 | BDBM50478347 | DTXSID00425754 | EU-0101161 | CCG-205235 | GTPL1431 | s2645 | MLS000860049 | L000560 | SIB1757 | SIB-1757 | SIB-1757; SIB1757 | AKOS024456470 | NCGC00025047-03 | SCHEMBL179770 |
Specifications & PurityMoligand™, ≥98%
Biochemical and Physiological MechanismsA highly selective antagonist for the mGlu5metabotropic glutamate receptor subtype; displays an IC50value of 0.4μM at hmGlu5compared with > 30μM at hmGlu1b, hmGlu2, hmGlu4, hmGlu6, hmGlu7and hmGlu8.
Storage TempStore at -20°C
Shipped InIce chest + Ice pads
GradeMoligand™
Action TypeALLOSTERIC MODULATOR
Mechanism of actionAllosteric modulator of mGlu 5 receptor
Product Description

SIB-1757 is a highly selective and noncompetitive antagonist of mGlu5 receptor with an IC50 of 0.4 μM。


Associated Targets(Human)

GRM5 Tchem Metabotropic glutamate receptor 5 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

Names and Identifiers

Pubchem Sid488195160
Pubchem Sid Urlhttps://pubchem.ncbi.nlm.nih.gov/substance/488195160
IUPAC Name 6-methyl-2-phenyldiazenylpyridin-3-ol
INCHI InChI=1S/C12H11N3O/c1-9-7-8-11(16)12(13-9)15-14-10-5-3-2-4-6-10/h2-8,16H,1H3
InChi Key LOCPVWIREQIGNQ-UHFFFAOYSA-N
Canonical SMILES CC1=NC(=C(C=C1)O)N=NC2=CC=CC=C2
Isomeric SMILES CC1=NC(=C(C=C1)O)N=NC2=CC=CC=C2
PubChem CID 5218788
Molecular Weight 213.24

Certificates

C of A & Other Certificates

Find and download the COA for your product by matching the lot number on the packaging.

10 results found

Lot NumberCertificate TypeDateItem
E23081022Certificate of AnalysisMar 31, 2023 S287942
E23081335Certificate of AnalysisMar 31, 2023 S287942
E2308826Certificate of AnalysisMar 31, 2023 S287942
E2308917Certificate of AnalysisMar 31, 2023 S287942
E2308920Certificate of AnalysisMar 31, 2023 S287942
E2308949Certificate of AnalysisMar 31, 2023 S287942
E2308955Certificate of AnalysisMar 31, 2023 S287942
E2308980Certificate of AnalysisMar 31, 2023 S287942
E2308987Certificate of AnalysisMar 31, 2023 S287942
E2308988Certificate of AnalysisMar 31, 2023 S287942

Chemical and Physical Properties

SolubilitySolvent:DMSO, Max Conc. mg/mL: None, Max Conc. mM: 100

Safety and Hazards(GHS)

Pictogram(s) GHS07
Signal Warning
Hazard Statements

H315:Causes skin irritation

H319:Causes serious eye irritation

H335:May cause respiratory irritation

Precautionary Statements

P261:Avoid breathing dust/fume/gas/mist/vapors/spray.

P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing.

P280:Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352:IF ON SKIN: wash with plenty of water.

P321:Specific treatment (see ... on this label).

P405:Store locked up.

P501:Dispose of contents/container to ...

P264:Wash hands [and …] thoroughly after handling.

P271:Use only outdoors or in a well-ventilated area.

P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing.

P403+P233:Store in a well-ventilated place. Keep container tightly closed.

P362+P364:Take off contaminated clothing and wash it before reuse.

P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes.

P337+P317:If eye irritation persists: Get medical help.

P332+P317:If skin irritation occurs: Get medical help.

P319:Get medical help if you feel unwell.

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Solution Calculators