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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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S287942-5mg | 5mg | In stock | $53.90 | |
S287942-10mg | 10mg | In stock | $81.90 | |
S287942-25mg | 25mg | In stock | $183.90 | |
S287942-50mg | 50mg | In stock | $342.90 | |
S287942-100mg | 100mg | In stock | $615.90 |
Highly selective mGlu5antagonist
Synonyms | NCGC00185991-01 | CHEBI:93722 | SR-01000076142-1 | BCP33033 | BDBM50478347 | DTXSID00425754 | EU-0101161 | CCG-205235 | GTPL1431 | s2645 | MLS000860049 | L000560 | SIB1757 | SIB-1757 | SIB-1757; SIB1757 | AKOS024456470 | NCGC00025047-03 | SCHEMBL179770 | |
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Specifications & Purity | Moligand™, ≥98% |
Biochemical and Physiological Mechanisms | A highly selective antagonist for the mGlu5metabotropic glutamate receptor subtype; displays an IC50value of 0.4μM at hmGlu5compared with > 30μM at hmGlu1b, hmGlu2, hmGlu4, hmGlu6, hmGlu7and hmGlu8. |
Storage Temp | Store at -20°C |
Shipped In | Ice chest + Ice pads |
Grade | Moligand™ |
Action Type | ALLOSTERIC MODULATOR |
Mechanism of action | Allosteric modulator of mGlu 5 receptor |
Product Description | SIB-1757 is a highly selective and noncompetitive antagonist of mGlu5 receptor with an IC50 of 0.4 μM。 |
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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Pubchem Sid | 488195160 |
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Pubchem Sid Url | https://pubchem.ncbi.nlm.nih.gov/substance/488195160 |
IUPAC Name | 6-methyl-2-phenyldiazenylpyridin-3-ol |
INCHI | InChI=1S/C12H11N3O/c1-9-7-8-11(16)12(13-9)15-14-10-5-3-2-4-6-10/h2-8,16H,1H3 |
InChi Key | LOCPVWIREQIGNQ-UHFFFAOYSA-N |
Canonical SMILES | CC1=NC(=C(C=C1)O)N=NC2=CC=CC=C2 |
Isomeric SMILES | CC1=NC(=C(C=C1)O)N=NC2=CC=CC=C2 |
PubChem CID | 5218788 |
Molecular Weight | 213.24 |
Find and download the COA for your product by matching the lot number on the packaging.
10 results found
Lot Number | Certificate Type | Date | Item |
---|---|---|---|
E23081022 | Certificate of Analysis | Mar 31, 2023 | S287942 |
E23081335 | Certificate of Analysis | Mar 31, 2023 | S287942 |
E2308826 | Certificate of Analysis | Mar 31, 2023 | S287942 |
E2308917 | Certificate of Analysis | Mar 31, 2023 | S287942 |
E2308920 | Certificate of Analysis | Mar 31, 2023 | S287942 |
E2308949 | Certificate of Analysis | Mar 31, 2023 | S287942 |
E2308955 | Certificate of Analysis | Mar 31, 2023 | S287942 |
E2308980 | Certificate of Analysis | Mar 31, 2023 | S287942 |
E2308987 | Certificate of Analysis | Mar 31, 2023 | S287942 |
E2308988 | Certificate of Analysis | Mar 31, 2023 | S287942 |
Solubility | Solvent:DMSO, Max Conc. mg/mL: None, Max Conc. mM: 100 |
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Pictogram(s) | GHS07 |
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Signal | Warning |
Hazard Statements | H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation |
Precautionary Statements | P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P271:Use only outdoors or in a well-ventilated area. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P362+P364:Take off contaminated clothing and wash it before reuse. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P337+P317:If eye irritation persists: Get medical help. P332+P317:If skin irritation occurs: Get medical help. P319:Get medical help if you feel unwell. |