Determine the necessary mass, volume, or concentration for preparing a solution.
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SKU | Size | Availability | Price | Qty |
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S421489-1ml | 1ml | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $69.90 |
Synonyms | SMR004703325 | Sildenafil- Bio-X | DTXCID003579 | G04BE03 | HSDB 7305 | Spectrum3_001892 | UK-92480 | sildenafilum | SpecPlus_000798 | UNII-3M7OB98Y7H | 5-{2-ETHOXY-5-[(4-METHYLPIPERAZIN-1-YL)SULFONYL]PHENYL}-1-METHYL-3-PROPYL-1H,6H,7H-PYRAZOLO[4,3-D]PYRI |
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Specifications & Purity | Moligand™, 10mM in Water |
Biochemical and Physiological Mechanisms | Sildenafil is a selective inhibitor of the type 5 cGMP phosphodiesterase (PDE5 inhibitor) which catalyzes the hydrolysis of 3',5'-cyclic guanosine monophosphate (cGMP). As a PDE5 inhibitor, Sildenafil has been reported to enhance neuro-, synapto- and angi |
Storage Temp | Store at -80°C |
Shipped In | Ice chest + Ice pads |
Grade | Moligand™ |
Product Description | Sildenafil, one of the selective phosphodiesterase-5 (PDE5) inhibitors(IC50= 5.22 nM), is considered the best treatment for erectile dysfunction. |
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IUPAC Name | 5-[2-ethoxy-5-(4-methylpiperazin-1-yl)sulfonylphenyl]-1-methyl-3-propyl-6H-pyrazolo[4,3-d]pyrimidin-7-one |
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INCHI | InChI=1S/C22H30N6O4S/c1-5-7-17-19-20(27(4)25-17)22(29)24-21(23-19)16-14-15(8-9-18(16)32-6-2)33(30,31)28-12-10-26(3)11-13-28/h8-9,14H,5-7,10-13H2,1-4H3,(H,23,24,29) |
InChi Key | BNRNXUUZRGQAQC-UHFFFAOYSA-N |
Canonical SMILES | CCCC1=NN(C2=C1N=C(NC2=O)C3=C(C=CC(=C3)S(=O)(=O)N4CCN(CC4)C)OCC)C |
Isomeric SMILES | CCCC1=NN(C2=C1N=C(NC2=O)C3=C(C=CC(=C3)S(=O)(=O)N4CCN(CC4)C)OCC)C |
PubChem CID | 135398744 |
Molecular Weight | 474.58 |
Enter Lot Number to search for COA:
Pictogram(s) | GHS07 |
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Signal | Warning |
Hazard Statements | H319:Causes serious eye irritation H412:Harmful to aquatic life with long lasting effects H302:Harmful if swallowed |
Precautionary Statements | P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P273:Avoid release to the environment. P280:Wear protective gloves/protective clothing/eye protection/face protection. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P270:Do not eat, drink or smoke when using this product. P330:Rinse mouth. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P301+P317:IF SWALLOWED: Get medical help. P337+P317:If eye irritation persists: Get medical help. |
1. Yang Yi-Ting, Yan Bin, Li Yu-Hua, Guo Li-Na, Wang Wei-Wei, Liu Li-Jie, Yu He-Guo, Diao Hua. (2023) Phosphodiesterase 10A inhibitor PF-2545920 as a prospective agent for the clinical promotion of sperm motility. ASIAN JOURNAL OF ANDROLOGY, (10.4103/aja2022117). [PMID:37026191] [10.4103/aja2022117] |
2. Kun Liu, Xiaohan Zhang, Xiongfeng Zhou, Xinming Huo, Xiaohao Wang, Kostya (Ken) Ostrikov. (2022) Experimental investigation of an atmospheric pressure plasma jet as an ion source for on-site mass-spectrometry analysis of nonvolatile solid samples: the integration effect of thermal desorption and ionization. JOURNAL OF PHYSICS D-APPLIED PHYSICS, 55 (48): (485202). [PMID:] [10.1088/1361-6463/ac968a] |
3. Hao Gu, Kang Ma, Weiqian Zhao, Lirong Qiu, Wei Xu. (2021) A general purpose MALDI matrix for the analyses of small organic, peptide and protein molecules. ANALYST, 146 (12): (4080-4086). [PMID:34052846] [10.1039/D1AN00474C] |
4. Ting-Ting ZOU, Jin-Yi YANG, Zhen-Lin XU, Hong WANG, Yuan-Ming SUN, Hong-Tao LEI, Xue-Cai TAN, Yu-Dong SHEN. (2019) Detection of Tadalafil and Its Analogues in Health Wine and Oral Liquid by Microwell Lateral Flow Immunochromatography Assay. CHINESE JOURNAL OF ANALYTICAL CHEMISTRY, 47 (1249). [PMID:] [10.1016/S1872-2040(19)61182-5] |
1. Yang Yi-Ting, Yan Bin, Li Yu-Hua, Guo Li-Na, Wang Wei-Wei, Liu Li-Jie, Yu He-Guo, Diao Hua. (2023) Phosphodiesterase 10A inhibitor PF-2545920 as a prospective agent for the clinical promotion of sperm motility. ASIAN JOURNAL OF ANDROLOGY, (10.4103/aja2022117). [PMID:37026191] [10.4103/aja2022117] |
2. Kun Liu, Xiaohan Zhang, Xiongfeng Zhou, Xinming Huo, Xiaohao Wang, Kostya (Ken) Ostrikov. (2022) Experimental investigation of an atmospheric pressure plasma jet as an ion source for on-site mass-spectrometry analysis of nonvolatile solid samples: the integration effect of thermal desorption and ionization. JOURNAL OF PHYSICS D-APPLIED PHYSICS, 55 (48): (485202). [PMID:] [10.1088/1361-6463/ac968a] |
3. Hao Gu, Kang Ma, Weiqian Zhao, Lirong Qiu, Wei Xu. (2021) A general purpose MALDI matrix for the analyses of small organic, peptide and protein molecules. ANALYST, 146 (12): (4080-4086). [PMID:34052846] [10.1039/D1AN00474C] |
4. Ting-Ting ZOU, Jin-Yi YANG, Zhen-Lin XU, Hong WANG, Yuan-Ming SUN, Hong-Tao LEI, Xue-Cai TAN, Yu-Dong SHEN. (2019) Detection of Tadalafil and Its Analogues in Health Wine and Oral Liquid by Microwell Lateral Flow Immunochromatography Assay. CHINESE JOURNAL OF ANALYTICAL CHEMISTRY, 47 (1249). [PMID:] [10.1016/S1872-2040(19)61182-5] |