Determine the necessary mass, volume, or concentration for preparing a solution.
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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S422725-1ml | 1ml | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $103.90 |
Synonyms | silibinin | Silybin | 22888-70-6 | Silibinin A | Silybin A | Silymarin I | Flavobin | SILYMARIN | Silibinine | Silymarine I | Silibininum | Silibinina | Silibinin [INN] | Silliver | Silybine | Flavobin Spofa | 36804-17-8 | (2R,3R)-3,5,7-trihydroxy-2-((2R,3R)-3-(4-hydroxy-3-methoxyphenyl)- |
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Specifications & Purity | Moligand™, 10mM in DMSO |
Storage Temp | Store at -80°C |
Shipped In | Ice chest + Ice pads |
Grade | Moligand™ |
Product Description | Silibinin, the main flavonoid extracted from the milk thistle Silybum marianum, displays hepatoprotective properties in acute and chronic liver injury.Silibinin itself is mixture of two diastereomers silibinin A and silybinin B in approximately equimolar ratio. |
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IUPAC Name | (2R,3R)-3,5,7-trihydroxy-2-[(2R,3R)-3-(4-hydroxy-3-methoxyphenyl)-2-(hydroxymethyl)-2,3-dihydro-1,4-benzodioxin-6-yl]-2,3-dihydrochromen-4-one |
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INCHI | InChI=1S/C25H22O10/c1-32-17-6-11(2-4-14(17)28)24-20(10-26)33-16-5-3-12(7-18(16)34-24)25-23(31)22(30)21-15(29)8-13(27)9-19(21)35-25/h2-9,20,23-29,31H,10H2,1H3/t20-,23+,24-,25-/m1/s1 |
InChi Key | SEBFKMXJBCUCAI-HKTJVKLFSA-N |
Canonical SMILES | COC1=C(C=CC(=C1)C2C(OC3=C(O2)C=C(C=C3)C4C(C(=O)C5=C(C=C(C=C5O4)O)O)O)CO)O |
Isomeric SMILES | COC1=C(C=CC(=C1)[C@@H]2[C@H](OC3=C(O2)C=C(C=C3)[C@@H]4[C@H](C(=O)C5=C(C=C(C=C5O4)O)O)O)CO)O |
WGK Germany | 3 |
RTECS | DJ2981770 |
Alternate CAS | 36804-17-8;142797-34-0 |
PubChem CID | 31553 |
Molecular Weight | 482.44 |
Enter Lot Number to search for COA:
Pictogram(s) | GHS07 |
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Signal | Warning |
Hazard Statements | H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation |
Precautionary Statements | P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P271:Use only outdoors or in a well-ventilated area. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P362+P364:Take off contaminated clothing and wash it before reuse. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P337+P317:If eye irritation persists: Get medical help. P332+P317:If skin irritation occurs: Get medical help. P319:Get medical help if you feel unwell. |
WGK Germany | 3 |
RTECS | DJ2981770 |
1. Yanan Wang, Huichao Wei, Keyang Li, Liru Liu, Yingfei Zhu, Xinyuan Wang, Jiahui Yan, Liangmin Yu, Xuefeng Yan, Zhiyu He. (2024) Ros-responsive dextran-phenylboronic acid-silibinin nanoparticles for targeting delivery of BAPTA-AM to effectively eliminate calcium overload-mediated inflammatory cascades and mitochondrial apoptosis: Alleviating acute liver injury. CHEMICAL ENGINEERING JOURNAL, 480 (148283). [PMID:] |
2. Guanglu Wang, Yue Xin, Kaixin Ping, Xuhui Xu, Ying Sun, Xing Li, Xinying Guan, Jingquan Dong. (2023) Silybin mitigates chronic Avermectin exposure-induced intestinal damage and growth inhibition in carp. ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY, (104351). [PMID:38135203] |
3. Shuai-Nan Zhang, Qi Liu, Xu-Zhao Li, Wu-De Yang, Ying Zhou. (2024) Liver protein and metabolite biolabels reveal hepatoprotective effects and active compounds of Eucommiae folium: Exploration of new application of herb based on multi-omics and bioinformatics. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 239 (19): (115870). [PMID:38008044] |
4. Pan En-Zhuang, Xin Yue, Li Xue-Qing, Wu Xin-Yu, Tan Xue-Lian, Dong Jing-Quan. (2023) Ameliorative effects of silybin against avermectin-triggered carp spleen mitochondrial dysfunction and apoptosis through inhibition of PERK-ATF4-CHOP signaling pathway. FISH PHYSIOLOGY AND BIOCHEMISTRY, (1-16). [PMID:37542703] |
5. Yanxia Liu, Minghuo Wu, Miaomiao Ren, Haijun Bao, Qing’an Wang, Nan Wang, Shibo Sun, Jianqiang Xu, Xiaojing Yang, Xu Zhao, Yongming Bao, Gaohong He, Weiping Xu. (2023) From Medical Herb to Functional Food: Development of a Fermented Milk Containing Silybin and Protein from Milk Thistle. Foods, 12 (6): (1308). [PMID:36981234] |
6. Qiang-Ming Li, Xiu-Rong Yang, Xue-Qiang Zha, Li-Hua Pan, Dan-Dan Zang, Feng-Yun Zhang, Jian-Ping Luo. (2022) Protective Effects of Three Flavonoids from Dendrobium huoshanense Flowers on Alcohol-Induced Hepatocyte Injury via Activating Nrf2 and Inhibiting NF-κB Pathways. CHEMISTRY & BIODIVERSITY, 19 (8): (e202200471). [PMID:35774029] |
7. Rong Xu, Siyan Qiu, Jie Zhang, Xiaoli Liu, Ling Zhang, Haizhu Xing, Min You, Man Wang, Yuting Lu, Peng Zhang, Jing Zhu. (2022) Silibinin Schiff Base Derivatives Counteract CCl4-Induced Acute Liver Injury by Enhancing Anti-Inflammatory and Antiapoptotic Bioactivities. Drug Design Development and Therapy, 16 (1441-1456). [PMID:35601675] |
8. Xinran Shi, Liang Ji, Yuanyuan Hu, Jinyu Gu, Liming Wang, Wenwen Lu, Jiali Meng, Yan Du, Lingzhong Huang, Dongxia Nie, Yanyan Yu. (2022) Dual-responsive zeolitic imidazolate framework-90 for the combined detection and intracellular imaging of ATP and ROS. SENSORS AND ACTUATORS B-CHEMICAL, 363 (131848). [PMID:] |
9. Bai Yang, Chen Jiaqi, Hu Weijian, Wang Lei, Wu Yulian, Yu Shi’an. (2022) Silibinin Therapy Improves Cholangiocarcinoma Outcomes by Regulating ERK/Mitochondrial Pathway. Frontiers in Pharmacology, 13 (975). [PMID:35401195] |
10. Yan Huang, Dandan Pu, Zhilin Hao, Xiao Yang, Yuyu Zhang. (2021) The Effect of Prickly Ash (Zanthoxylum bungeanum Maxim) on the Taste Perception of Stewed Sheep Tail Fat by LC-QTOF-MS/MS and a Chemometrics Analysis. Foods, 10 (11): (2709). [PMID:34828990] |
11. Pengfei Xu,Qi Yin,Jianan Shen,Lingli Chen,Haijun Yu,Zhiwen Zhang,Yaping Li. (2013-07-09) Synergistic inhibition of breast cancer metastasis by silibinin-loaded lipid nanoparticles containing TPGS.. International journal of pharmaceutics, 454 ((1)): (21-30). [PMID:23830941] |
1. Yanan Wang, Huichao Wei, Keyang Li, Liru Liu, Yingfei Zhu, Xinyuan Wang, Jiahui Yan, Liangmin Yu, Xuefeng Yan, Zhiyu He. (2024) Ros-responsive dextran-phenylboronic acid-silibinin nanoparticles for targeting delivery of BAPTA-AM to effectively eliminate calcium overload-mediated inflammatory cascades and mitochondrial apoptosis: Alleviating acute liver injury. CHEMICAL ENGINEERING JOURNAL, 480 (148283). [PMID:] |
2. Guanglu Wang, Yue Xin, Kaixin Ping, Xuhui Xu, Ying Sun, Xing Li, Xinying Guan, Jingquan Dong. (2023) Silybin mitigates chronic Avermectin exposure-induced intestinal damage and growth inhibition in carp. ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY, (104351). [PMID:38135203] |
3. Shuai-Nan Zhang, Qi Liu, Xu-Zhao Li, Wu-De Yang, Ying Zhou. (2024) Liver protein and metabolite biolabels reveal hepatoprotective effects and active compounds of Eucommiae folium: Exploration of new application of herb based on multi-omics and bioinformatics. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 239 (19): (115870). [PMID:38008044] |
4. Pan En-Zhuang, Xin Yue, Li Xue-Qing, Wu Xin-Yu, Tan Xue-Lian, Dong Jing-Quan. (2023) Ameliorative effects of silybin against avermectin-triggered carp spleen mitochondrial dysfunction and apoptosis through inhibition of PERK-ATF4-CHOP signaling pathway. FISH PHYSIOLOGY AND BIOCHEMISTRY, (1-16). [PMID:37542703] |
5. Yanxia Liu, Minghuo Wu, Miaomiao Ren, Haijun Bao, Qing’an Wang, Nan Wang, Shibo Sun, Jianqiang Xu, Xiaojing Yang, Xu Zhao, Yongming Bao, Gaohong He, Weiping Xu. (2023) From Medical Herb to Functional Food: Development of a Fermented Milk Containing Silybin and Protein from Milk Thistle. Foods, 12 (6): (1308). [PMID:36981234] |
6. Qiang-Ming Li, Xiu-Rong Yang, Xue-Qiang Zha, Li-Hua Pan, Dan-Dan Zang, Feng-Yun Zhang, Jian-Ping Luo. (2022) Protective Effects of Three Flavonoids from Dendrobium huoshanense Flowers on Alcohol-Induced Hepatocyte Injury via Activating Nrf2 and Inhibiting NF-κB Pathways. CHEMISTRY & BIODIVERSITY, 19 (8): (e202200471). [PMID:35774029] |
7. Rong Xu, Siyan Qiu, Jie Zhang, Xiaoli Liu, Ling Zhang, Haizhu Xing, Min You, Man Wang, Yuting Lu, Peng Zhang, Jing Zhu. (2022) Silibinin Schiff Base Derivatives Counteract CCl4-Induced Acute Liver Injury by Enhancing Anti-Inflammatory and Antiapoptotic Bioactivities. Drug Design Development and Therapy, 16 (1441-1456). [PMID:35601675] |
8. Xinran Shi, Liang Ji, Yuanyuan Hu, Jinyu Gu, Liming Wang, Wenwen Lu, Jiali Meng, Yan Du, Lingzhong Huang, Dongxia Nie, Yanyan Yu. (2022) Dual-responsive zeolitic imidazolate framework-90 for the combined detection and intracellular imaging of ATP and ROS. SENSORS AND ACTUATORS B-CHEMICAL, 363 (131848). [PMID:] |
9. Bai Yang, Chen Jiaqi, Hu Weijian, Wang Lei, Wu Yulian, Yu Shi’an. (2022) Silibinin Therapy Improves Cholangiocarcinoma Outcomes by Regulating ERK/Mitochondrial Pathway. Frontiers in Pharmacology, 13 (975). [PMID:35401195] |
10. Yan Huang, Dandan Pu, Zhilin Hao, Xiao Yang, Yuyu Zhang. (2021) The Effect of Prickly Ash (Zanthoxylum bungeanum Maxim) on the Taste Perception of Stewed Sheep Tail Fat by LC-QTOF-MS/MS and a Chemometrics Analysis. Foods, 10 (11): (2709). [PMID:34828990] |
11. Pengfei Xu,Qi Yin,Jianan Shen,Lingli Chen,Haijun Yu,Zhiwen Zhang,Yaping Li. (2013-07-09) Synergistic inhibition of breast cancer metastasis by silibinin-loaded lipid nanoparticles containing TPGS.. International journal of pharmaceutics, 454 ((1)): (21-30). [PMID:23830941] |