Determine the necessary mass, volume, or concentration for preparing a solution.
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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S129538-250mg | 250mg | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $149.90 | |
S129538-1g | 1g | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $13.90 | |
S129538-5g | 5g | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $23.90 | |
S129538-10g | 10g | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $32.90 | |
S129538-25g | 25g | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $56.90 | |
S129538-100g | 100g | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $159.90 |
HMG-CoA reductase inhibitor
Synonyms | BRN 4768037 | Butanoic acid, 2,2-dimethyl-, (1S,3R,7S,8S,8aR)-1,2,3,7,8,8a-hexahydro-3,7-dimethyl-8-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-1-naphthalenyl ester | MK 0733 | SIMVASTATIN [MART.] | Sinvascor | L 644128-000U | Zocord | Sim |
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Specifications & Purity | Moligand™, ≥97%(HPLC) |
Biochemical and Physiological Mechanisms | Simvastatin is an HMGCR (HMG-CoA reductase) inhibitor with anti-proliferative properties. This compound has been shown to modulate purified bovine pituitary 20 S proteasome via mild stimulation of chymotrypsin-like activity and inhibition of peptidylgluta |
Storage Temp | Store at 2-8°C,Argon charged |
Shipped In | Wet ice |
Grade | Moligand™ |
Action Type | INHIBITOR |
Mechanism of action | HMG-CoA reductase inhibitor |
Note | Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details. |
Product Description | Product Description Simvastatin is a prodrug. Simvastatin is a semisynthetic derivative/analog of lovastatin. Simvastatin is insoluble in water but is soluble in polar organic solvents. Product Application Simvastatin has been used: |
ALogP | 4.7 |
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Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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IUPAC Name | [(1S,3R,7S,8S,8aR)-8-[2-[(2R,4R)-4-hydroxy-6-oxooxan-2-yl]ethyl]-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl] 2,2-dimethylbutanoate |
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INCHI | InChI=1S/C25H38O5/c1-6-25(4,5)24(28)30-21-12-15(2)11-17-8-7-16(3)20(23(17)21)10-9-19-13-18(26)14-22(27)29-19/h7-8,11,15-16,18-21,23,26H,6,9-10,12-14H2,1-5H3/t15-,16-,18+,19+,20-,21-,23-/m0/s1 |
InChi Key | RYMZZMVNJRMUDD-HGQWONQESA-N |
Canonical SMILES | CCC(C)(C)C(=O)OC1CC(C=C2C1C(C(C=C2)C)CCC3CC(CC(=O)O3)O)C |
Isomeric SMILES | CCC(C)(C)C(=O)O[C@H]1C[C@H](C=C2[C@H]1[C@H]([C@H](C=C2)C)CC[C@@H]3C[C@H](CC(=O)O3)O)C |
WGK Germany | 2 |
RTECS | EK7798000 |
PubChem CID | 54454 |
Molecular Weight | 418.57 |
Reaxy-Rn | 4768037 |
ChEMBL Ligand | CHEMBL1064 |
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PubChem CID | 54454 |
CAS Registry No. | 79902-63-9 |
ChEBI | CHEBI:9150 |
DrugBank Ligand | DB00641 |
Wikipedia | Simvastatin |
PEP | simvastatin |
DrugCentral Ligand | 2445 |
Enter Lot Number to search for COA:
Find and download the COA for your product by matching the lot number on the packaging.
Lot Number | Certificate Type | Date | Item |
---|---|---|---|
J2408658 | Certificate of Analysis | Sep 12, 2024 | S129538 |
J2408659 | Certificate of Analysis | Sep 12, 2024 | S129538 |
J2408660 | Certificate of Analysis | Sep 12, 2024 | S129538 |
J2408662 | Certificate of Analysis | Sep 12, 2024 | S129538 |
J2408664 | Certificate of Analysis | Sep 12, 2024 | S129538 |
J2408670 | Certificate of Analysis | Sep 12, 2024 | S129538 |
L2301383 | Certificate of Analysis | Nov 17, 2023 | S129538 |
A2404354 | Certificate of Analysis | Nov 17, 2023 | S129538 |
L2301382 | Certificate of Analysis | Nov 17, 2023 | S129538 |
L2301381 | Certificate of Analysis | Nov 17, 2023 | S129538 |
L2301267 | Certificate of Analysis | Nov 17, 2023 | S129538 |
L2301266 | Certificate of Analysis | Nov 17, 2023 | S129538 |
I2414041 | Certificate of Analysis | Nov 17, 2023 | S129538 |
K2302026 | Certificate of Analysis | Sep 19, 2023 | S129538 |
L2103127 | Certificate of Analysis | Sep 19, 2023 | S129538 |
L2103128 | Certificate of Analysis | Sep 19, 2023 | S129538 |
L2103129 | Certificate of Analysis | Sep 19, 2023 | S129538 |
K2017174 | Certificate of Analysis | Sep 20, 2022 | S129538 |
G2315047 | Certificate of Analysis | Aug 25, 2021 | S129538 |
E2305057 | Certificate of Analysis | Aug 25, 2021 | S129538 |
D2328032 | Certificate of Analysis | Aug 25, 2021 | S129538 |
Solubility | Soluble in DMSO (>25 mg/ml), ethanol (>25 mg/ml), water (0.03 mg/l), and methanol. |
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Sensitivity | Moisture & Air sensitive |
Specific Rotation[α] | 293° (C=1,CH3CN) |
Melt Point(°C) | 134°C |
Pictogram(s) | GHS09, GHS07 |
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Signal | Warning |
Hazard Statements | H315:Causes skin irritation H410:Very toxic to aquatic life with long lasting effects H362:May cause harm to breast-fed children |
Precautionary Statements | P273:Avoid release to the environment. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P260:Do not breathe dust/fume/gas/mist/vapors/spray. P270:Do not eat, drink or smoke when using this product. P362+P364:Take off contaminated clothing and wash it before reuse. P391:Collect spillage. P263:Avoid contact during pregnancy/while nursing. P203:Obtain, read and follow all safety instructions before use. P318:if exposed or concerned, get medical advice. P332+P317:If skin irritation occurs: Get medical help. |
WGK Germany | 2 |
RTECS | EK7798000 |
Reaxy-Rn | 4768037 |
Merck Index | 8539 |
Starting at $51.90
1. Yulin Mo, Yanjun Yang, Jingqi Zeng, Weikun Ma, Yuxin Guan, Jingxi Guo, Xiaochun Wu, Dingkun Liu, Liang Feng, Xiaobin Jia, Bing Yang. (2023) Enhancing the Biopharmacological Characteristics of Asperosaponin VI: Unveiling Dynamic Self-Assembly Phase Transitions in the Gastrointestinal Environment. International Journal of Nanomedicine, [PMID:38084126] [10.2147/IJN.S436372] |
2. Xiaojie Xu, Jiahui Zuo, Huajing Zeng, Yuan Zhao, Zengjie Fan. (2023) Improving Osseointegration Potential of 3D Printed PEEK Implants with Biomimetic Periodontal Ligament Fiber Hydrogel Surface Modifications. ADVANCED FUNCTIONAL MATERIALS, (2308811). [PMID:] [10.1002/adfm.202308811] |
3. Xuejing Yang, Wenyu Cao, Xun Gu, Lijie Zheng, Qiuyue Wang, Yingying Li, Fang Wei, Tao Ma, Lu Zhang, Qingqing Wang. (2023) Simvastatin nanocrystals-based dissolving microneedles for wound healing. INTERNATIONAL JOURNAL OF PHARMACEUTICS, 647 (3): (123543). [PMID:37879572] [10.1016/j.ijpharm.2023.123543] |
4. Wei Peng, Yufeng Qian, Xuchen Qi. (2023) Efficacy of a novel glioma therapy based on ferroptosis induced by layered double hydroxide loaded with simvastatin. ENVIRONMENTAL RESEARCH, 238 (11): (117112). [PMID:37717807] [10.1016/j.envres.2023.117112] |
5. Qingxin Shi, Yuqi Lin, Lu Huang, Shuna Jin, Rongzeng Huang, Lijun Zhang, Chengwu Song, Lei Xu, Shiying Zhang. (2023) Elucidating the mechanisms underlying the anti-hyperlipidemic effects of Laportea bulbifera using integrated serum metabolomics and network pharmacology. BIOMEDICAL CHROMATOGRAPHY, 37 (10): (e5707). [PMID:37496197] [10.1002/bmc.5707] |
6. Yanbin Zhao, Peng He, Junyan Yao, Mei Li, Bin Wang, Linyuan Han, Zhihai Huang, Chao Guo, Jing Bai, Feng Xue, Yu Cong, Weihua Cai, Paul K. Chu, Chenglin Chu. (2023) pH/NIR-responsive and self-healing coatings with bacteria killing, osteogenesis, and angiogenesis performances on magnesium alloy. BIOMATERIALS, 301 (122237). [PMID:37467596] [10.1016/j.biomaterials.2023.122237] |
7. Qiao Bian, Chao Guo, Shuquan Cui, Jia Liu, Guohua Xu, Wei Feng. (2023) Accelerating bone regeneration in cranial defects using an injectable organic–inorganic composite hydrogel. Journal of Materials Chemistry B, 11 (16): (3713-3726). [PMID:37066627] [10.1039/D3TB00332A] |
8. Shuwen Xu, Zhiyong Wu, Gaofeng Cai, Yue Zhang, Song Peng, Lina Jiao, Zhenguang Liu, Yang Yang, Deyun Wang. (2023) Astragalus polysaccharides combined with simvastatin as an immunostimulant enhances the immune adjuvanticity of oil-in-water emulsion and immune responses in mice. VACCINE, 41 (1684). [PMID:36754767] [10.1016/j.vaccine.2023.01.069] |
9. Ling-Feng Zhang, Xing-Huan Wang, Cheng-Lu Zhang, Jaiwoo Lee, Bo-Wen Duan, Lei Xing, Ling Li, Yu-Kyoung Oh, Hu-Lin Jiang. (2022) Sequential Nano-Penetrators of Capillarized Liver Sinusoids and Extracellular Matrix Barriers for Liver Fibrosis Therapy. ACS Nano, 16 (9): (14029–14042). [PMID:36036898] [10.1021/acsnano.2c03858] |
10. Mohammed A. Al-Baadani, Kendrick Hii Ru Yie, Abdullrahman M. Al-Bishari, Bilal A. Alshobi, Zixin Zhou, Kai Fang, Binwei Dai, Yiding Shen, Jianfeng Ma, Jinsong Liu, Xinkun Shen. (2021) Co-electrospinning polycaprolactone/gelatin membrane as a tunable drug delivery system for bone tissue regeneration. MATERIALS & DESIGN, 209 (109962). [PMID:] [10.1016/j.matdes.2021.109962] |
11. Li-Jun Deng, Yan-Lin Wu, Xian-Hua He, Ke-Nan Xie, Lu Xie, Yi Deng. (2018) Simvastatin delivery on PEEK for bioactivity and osteogenesis enhancements. JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION, 29 (18): (2237-2251). [PMID:30307376] [10.1080/09205063.2018.1534668] |
1. Denys A et al.. (2022) Binge Ethanol Exposure in Mice Represses Expression of Genes Involved in Osteoblast Function and Induces Expression of Genes Involved in Osteoclast Differentiation Independently of Endogenous Catalase.. Toxicol Sci, 185 (2): (232-245). [PMID:34755883] |
2. Paškeviciute M & Petrikaite V. (2017) Differences of statin activity in 2D and 3D pancreatic cancer cell cultures.. Drug Des Devel Ther, 11 (3273-3280). [PMID:29180851] |
3. Wang KC et al.. (2016) Flow-dependent YAP/TAZ activities regulate endothelial phenotypes and atherosclerosis.. Proc Natl Acad Sci U S A, 113 (41): (11525-11530). [PMID:27671657] |
4. Peng Y et al.. (2017) Lovastatin Inhibits Cancer Stem Cells and Sensitizes to Chemo- and Photodynamic Therapy in Nasopharyngeal Carcinoma.. J Cancer, 8 (9): (1655-1664). [PMID:28775785] |
5. Dai B et al.. (2021) Synergistic effects of magnesium ions and simvastatin on attenuation of high-fat diet-induced bone loss.. Bioact Mater, 6 (8): (2511-2522). [PMID:33665494] |
6. Yulin Mo, Yanjun Yang, Jingqi Zeng, Weikun Ma, Yuxin Guan, Jingxi Guo, Xiaochun Wu, Dingkun Liu, Liang Feng, Xiaobin Jia, Bing Yang. (2023) Enhancing the Biopharmacological Characteristics of Asperosaponin VI: Unveiling Dynamic Self-Assembly Phase Transitions in the Gastrointestinal Environment. International Journal of Nanomedicine, [PMID:38084126] [10.2147/IJN.S436372] |
7. Xiaojie Xu, Jiahui Zuo, Huajing Zeng, Yuan Zhao, Zengjie Fan. (2023) Improving Osseointegration Potential of 3D Printed PEEK Implants with Biomimetic Periodontal Ligament Fiber Hydrogel Surface Modifications. ADVANCED FUNCTIONAL MATERIALS, (2308811). [PMID:] [10.1002/adfm.202308811] |
8. Xuejing Yang, Wenyu Cao, Xun Gu, Lijie Zheng, Qiuyue Wang, Yingying Li, Fang Wei, Tao Ma, Lu Zhang, Qingqing Wang. (2023) Simvastatin nanocrystals-based dissolving microneedles for wound healing. INTERNATIONAL JOURNAL OF PHARMACEUTICS, 647 (3): (123543). [PMID:37879572] [10.1016/j.ijpharm.2023.123543] |
9. Wei Peng, Yufeng Qian, Xuchen Qi. (2023) Efficacy of a novel glioma therapy based on ferroptosis induced by layered double hydroxide loaded with simvastatin. ENVIRONMENTAL RESEARCH, 238 (11): (117112). [PMID:37717807] [10.1016/j.envres.2023.117112] |
10. Qingxin Shi, Yuqi Lin, Lu Huang, Shuna Jin, Rongzeng Huang, Lijun Zhang, Chengwu Song, Lei Xu, Shiying Zhang. (2023) Elucidating the mechanisms underlying the anti-hyperlipidemic effects of Laportea bulbifera using integrated serum metabolomics and network pharmacology. BIOMEDICAL CHROMATOGRAPHY, 37 (10): (e5707). [PMID:37496197] [10.1002/bmc.5707] |
11. Yanbin Zhao, Peng He, Junyan Yao, Mei Li, Bin Wang, Linyuan Han, Zhihai Huang, Chao Guo, Jing Bai, Feng Xue, Yu Cong, Weihua Cai, Paul K. Chu, Chenglin Chu. (2023) pH/NIR-responsive and self-healing coatings with bacteria killing, osteogenesis, and angiogenesis performances on magnesium alloy. BIOMATERIALS, 301 (122237). [PMID:37467596] [10.1016/j.biomaterials.2023.122237] |
12. Qiao Bian, Chao Guo, Shuquan Cui, Jia Liu, Guohua Xu, Wei Feng. (2023) Accelerating bone regeneration in cranial defects using an injectable organic–inorganic composite hydrogel. Journal of Materials Chemistry B, 11 (16): (3713-3726). [PMID:37066627] [10.1039/D3TB00332A] |
13. Shuwen Xu, Zhiyong Wu, Gaofeng Cai, Yue Zhang, Song Peng, Lina Jiao, Zhenguang Liu, Yang Yang, Deyun Wang. (2023) Astragalus polysaccharides combined with simvastatin as an immunostimulant enhances the immune adjuvanticity of oil-in-water emulsion and immune responses in mice. VACCINE, 41 (1684). [PMID:36754767] [10.1016/j.vaccine.2023.01.069] |
14. Ling-Feng Zhang, Xing-Huan Wang, Cheng-Lu Zhang, Jaiwoo Lee, Bo-Wen Duan, Lei Xing, Ling Li, Yu-Kyoung Oh, Hu-Lin Jiang. (2022) Sequential Nano-Penetrators of Capillarized Liver Sinusoids and Extracellular Matrix Barriers for Liver Fibrosis Therapy. ACS Nano, 16 (9): (14029–14042). [PMID:36036898] [10.1021/acsnano.2c03858] |
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