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Sipatrigine - ≥99%(HPLC), high purity , CAS No.130800-90-7
NaVblocker; neuroprotective
Basic Description Synonyms Sipatrigine | 130800-90-7 | 2-(4-methylpiperazin-1-yl)-5-(2,3,5-trichlorophenyl)pyrimidin-4-amine | Sipatrigine [INN:BAN] | 619C89 | BW619C89 | BW 619C89 | BW-619C89 | OON9AVW1T3 | CHEMBL28854 | CHEBI:34977 | 2-(4-Methyl-1-piperazinyl)-5-(2,3,5-trichlorophenyl)-4-pyrimidinamin Specifications & Purity ≥99%(HPLC) Biochemical and Physiological Mechanisms Blocker of voltage-dependent sodium channels (NaV). Inhibits glutamate release; displays neuroprotective activity in rat models of cerebral ischemia. Also thought to block Ca2+channels. Analog of lamotrigine. Storage Temp Room temperature Shipped In Normal
Associated Targets(Human) Associated Targets(non-human) Names and Identifiers IUPAC Name 2-(4-methylpiperazin-1-yl)-5-(2,3,5-trichlorophenyl)pyrimidin-4-amine INCHI InChI=1S/C15H16Cl3N5/c1-22-2-4-23(5-3-22)15-20-8-11(14(19)21-15)10-6-9(16)7-12(17)13(10)18/h6-8H,2-5H2,1H3,(H2,19,20,21) InChi Key PDOCBJADCWMDGL-UHFFFAOYSA-N Canonical SMILES CN1CCN(CC1)C2=NC=C(C(=N2)N)C3=C(C(=CC(=C3)Cl)Cl)Cl Isomeric SMILES CN1CCN(CC1)C2=NC=C(C(=N2)N)C3=C(C(=CC(=C3)Cl)Cl)Cl PubChem CID 60803 Molecular Weight 372.68
Chemical and Physical Properties Solubility Solvent:DMSO, Max Conc. mg/mL: 37.27, Max Conc. mM: 100; Solvent:ethanol, Max Conc. mg/mL: 9.32, Max Conc. mM: 25
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