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SIS17 - 10mM in DMSO, high purity , CAS No.2374313-54-7
Basic Description Synonyms SIS17 | 2374313-54-7 | N'-Hexadecylthiophene-2-carbohydrazide | SIS-17 | CHEMBL4777961 | Hydroxypropyl methyl cellulose | C21H38N2OS | SIS 17; SIS17 | DTXSID701238689 | BCP31156 | EX-A6309 | ZUD31354 | BDBM50565135 | MFCD32201127 | s6687 | AKOS037649020 | BS-16273 | HY-128918 | CS-0102230 | D Specifications & Purity 10mM in DMSO Biochemical and Physiological Mechanisms SIS17 is a mammalian histone deacetylase 11 (HDAC 11)-specific inhibitor with IC50 of 0.83 μM. SIS17 inhibits the demyristoylation of HDAC11 substrate, serine hydroxymethyl transferase 2, without inhibiting other HDACs. Storage Temp Store at -80°C Shipped In Ice chest + Ice pads Product Description Information
SIS17 SIS17 is a mammalian histone deacetylase 11 (HDAC 11) -specific inhibitor with IC50 of 0.83 μM. SIS17 inhibits the demyristoylation of HDAC11 substrate, serine hydroxymethyl transferase 2, without inhibiting other HDACs.
Targets
HDAC11 (Cell-free assay) 0.83 μM
Product Properties ALogP 7.302 HBD Count 2 Rotatable Bond 17
Associated Targets(Human) Associated Targets(non-human) Mechanisms of Action Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References
Names and Identifiers IUPAC Name N'-hexadecylthiophene-2-carbohydrazide INCHI InChI=1S/C21H38N2OS/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18-22-23-21(24)20-17-16-19-25-20/h16-17,19,22H,2-15,18H2,1H3,(H,23,24) InChi Key HSHXDCVZWHOWCS-UHFFFAOYSA-N Canonical SMILES CCCCCCCCCCCCCCCCNNC(=O)C1=CC=CS1 Isomeric SMILES CCCCCCCCCCCCCCCCNNC(=O)C1=CC=CS1 PubChem CID 139035087 Molecular Weight 366.6
Chemical and Physical Properties DMSO(mg / mL) Max Solubility 73 DMSO(mM) Max Solubility 199.127114020731 Water(mg / mL) Max Solubility ＜1
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