Sivelestat - 98% (HPLC), high purity , Leukocyte elastase inhibitor, CAS No.127373-66-4, Leukocyte elastase inhibitor

Item Number

S166827

• Synonyms: Sivelestat | 127373-66-4 | Ono-5046 | 331731-18-1 | 2-[[2-[[4-(2,2-dimethylpropanoyloxy)phenyl]sulfonylamino]benzoyl]amino]acetic acid | ONO5046 | LY544349 | ABT-D2E7 | EI546 | Sivelestat (ONO-5046) | UNII-FYS6T7F842 | CHEMBL76688 | DWI62G0P59 | LY-544349 | EI546;LY544349;ONO5046 | Pr
• Specifications & Purity: Moligand™, ≥98%(HPLC)
• Biochemical and Physiological Mechanisms: Potent, selective, substrate competitive neutrophil elastase inhibitor (IC 50 values are 19-49 nM and 5.6 μM for leukocyte and pancreas elastase respectively). Suppresses neutrophil-induced capillary permeability and leukocyte kinetics. Active in vivo. Si
• Storage Temp: Protected from light,Store at -20°C
• Shipped In: Ice chest + Ice pads
• Grade: Moligand™
• Action Type: INHIBITOR
• Mechanism of action: Leukocyte elastase inhibitor
• Note: Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Product Description

Product description

Sivelestat (EI546) is a competitive inhibitor of human neutrophil elastase, with an IC50 of 44 nM and a Ki of 200 nM. Sivelestat (EI546) has the potential for the study of acute lung injury/acute respiratory distress syndrome or disseminated intravascular coagulation in COVID-19