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Sivelestat sodium salt - ≥98%(HPLC), high purity , CAS No.150374-95-1

1 Citations

≥98%(HPLC)

CAS#: 150374-95-1
Formula: C₂₀H₂₁N₂NaO₇S
Molecular Weight: 456.44
PubChem CID: 23664980

Item Number

S287743

Grouped product items
SKU	Size	Availability	Price
S287743-5mg	5mg	In stock	$49.90
S287743-10mg	10mg	In stock	$82.90
S287743-25mg	25mg	In stock	$186.90
S287743-50mg	50mg	In stock	$284.90
S287743-100mg	100mg	In stock	$513.90

Selective leukocyte elastase inhibitor

View related series

Anti-infection Elastase Metabolic Enzyme/Protease SARS-CoV

Basic Description

Synonyms	Sivelestat (sodium) \| HY-17443A \| NCGC00261500-01 \| SIVELESTAT SODIUM SALT ANHYDROUS [MI] \| sodium;2-[[2-[[4-(2,2-dimethylpropanoyloxy)phenyl]sulfonylamino]benzoyl]amino]acetate \| A14073 \| Q27236615 \| CCG-222119 \| J-008691 \| Sivelestat sodium anhydrous \|
Specifications & Purity	≥98%(HPLC)
Biochemical and Physiological Mechanisms	Selective leukocyte elastase inhibitor (IC50= 44 nM) that displays no activity at a range of other proteases. Inhibits NF-κB activation and LTB4-induced neutrophil transmigrationin vitro. Significantly attenuates ischemia-induced spinal cord injury, decre
Storage Temp	Store at -20°C,Desiccated
Shipped In	Ice chest + Ice pads

Associated Targets(Human)

ELANE Tclin Neutrophil elastase (3 Activities)

Discover Target: ELANE

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ELANE Tclin Leukocyte elastase (8173 Activities)

Discover Target: ELANE

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Names and Identifiers

IUPAC Name	sodium;2-[[2-[[4-(2,2-dimethylpropanoyloxy)phenyl]sulfonylamino]benzoyl]amino]acetate
INCHI	InChI=1S/C20H22N2O7S.Na/c1-20(2,3)19(26)29-13-8-10-14(11-9-13)30(27,28)22-16-7-5-4-6-15(16)18(25)21-12-17(23)24;/h4-11,22H,12H2,1-3H3,(H,21,25)(H,23,24);/q;+1/p-1
InChi Key	ZAIFANJZUGNYCK-UHFFFAOYSA-M
Canonical SMILES	CC(C)(C)C(=O)OC1=CC=C(C=C1)S(=O)(=O)NC2=CC=CC=C2C(=O)NCC(=O)[O-].[Na+]
Isomeric SMILES	CC(C)(C)C(=O)OC1=CC=C(C=C1)S(=O)(=O)NC2=CC=CC=C2C(=O)NCC(=O)[O-].[Na+]
PubChem CID	23664980
Molecular Weight	456.44

Certificates

Certificate of Analysis(COA)

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5 results found

Lot Number	Certificate Type	Date	Item
C2218307	Certificate of Analysis	Feb 17, 2022	S287743
C2218308	Certificate of Analysis	Feb 17, 2022	S287743
C2218309	Certificate of Analysis	Feb 17, 2022	S287743
C2218310	Certificate of Analysis	Feb 17, 2022	S287743
C2218311	Certificate of Analysis	Feb 17, 2022	S287743

Citations of This Product

How to Cite Aladdin Scientific Products?

1. Hao-Dong Yang, Zhi-Shu Tang, Tao-Tao Xue, Huai-Li Xu, Bao-Long Hou, Ya-Ya Zhu, Zeng-Hu Su, Hong-Bo Xu. (2023) Monoterpenoids from the root bark of Acanthopanax gracilistylus and their inhibitory effects on neutrophil elastase, 5-lipoxygenase, andcyclooxygenase-2 in vitro. PHYTOCHEMISTRY, 215 (113851). [PMID:37683990] [10.1016/j.phytochem.2023.113851]

References

1. Hao-Dong Yang, Zhi-Shu Tang, Tao-Tao Xue, Huai-Li Xu, Bao-Long Hou, Ya-Ya Zhu, Zeng-Hu Su, Hong-Bo Xu. (2023) Monoterpenoids from the root bark of Acanthopanax gracilistylus and their inhibitory effects on neutrophil elastase, 5-lipoxygenase, andcyclooxygenase-2 in vitro. PHYTOCHEMISTRY, 215 (113851). [PMID:37683990] [10.1016/j.phytochem.2023.113851]

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