Sivelestat sodium tetrahydrate - ≥98%, high purity , CAS No.201677-61-4

  • ≥98%
Item Number
S275861
Grouped product items
SKUSizeAvailabilityPrice Qty
S275861-5mg
5mg
In stock
$49.90
S275861-10mg
10mg
In stock
$82.90
S275861-25mg
25mg
In stock
$186.90
S275861-50mg
50mg
In stock
$284.90
S275861-100mg
100mg
In stock
$414.90
S275861-250mg
250mg
In stock
$933.90
S275861-1g
1g
In stock
$3,361.90
S275861-5g
5g
In stock
$15,126.90

Neutrophil elastase inhibitor

Basic Description

SynonymsLY544349 Sodium Hydrate | LY-544349 SODIUM HYDRATE | Tox21_112570 | (8R,9S,10R,13S,14S)-4-hydroxy-10,13-dimethyl-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthrene-3,17-quinone | CAS-201677-61-4 | EI-546 | Sivelestat (sodium salt hydrate) | A
Specifications & Purity≥98%
Biochemical and Physiological MechanismsIt is a competitive human neutrophil elastase (HNE) inhibitor (IC50 = 44 nm, Ki = 0.2 μ M)。 It also inhibited leukocyte elastase obtained from rabbits, rats, hamsters and mice (IC50 = 19 to 49 nm). But even at 100 μ At m, it also did not inhibit trypsin,
SourceSynthetic
Storage TempStore at -20°C
Shipped InIce chest + Ice pads
NoteWherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description

Store at Room Temperature. The product can be stored for up to 12 months.

Associated Targets(non-human)

Galc Galactocerebrosidase (11 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Plasmodium falciparum (966862 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
rep Replicase polyprotein 1ab (378 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

Mechanisms of Action

Mechanism of ActionAction Typetarget IDTarget NameTarget TypeTarget OrganismBinding Site NameReferences

Names and Identifiers

IUPAC Name sodium;2-[[2-[[4-(2,2-dimethylpropanoyloxy)phenyl]sulfonylamino]benzoyl]amino]acetate;tetrahydrate
INCHI InChI=1S/C20H22N2O7S.Na.4H2O/c1-20(2,3)19(26)29-13-8-10-14(11-9-13)30(27,28)22-16-7-5-4-6-15(16)18(25)21-12-17(23)24;;;;;/h4-11,22H,12H2,1-3H3,(H,21,25)(H,23,24);;4*1H2/q;+1;;;;/p-1
InChi Key PLHREJBSQUSUCW-UHFFFAOYSA-M
Canonical SMILES CC(C)(C)C(=O)OC1=CC=C(C=C1)S(=O)(=O)NC2=CC=CC=C2C(=O)NCC(=O)[O-].O.O.O.O.[Na+]
Isomeric SMILES CC(C)(C)C(=O)OC1=CC=C(C=C1)S(=O)(=O)NC2=CC=CC=C2C(=O)NCC(=O)[O-].O.O.O.O.[Na+]
PubChem CID 23663985
Molecular Weight 528.51

Certificates

Certificate of Analysis(COA)

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8 results found

Lot NumberCertificate TypeDateItem
B2225300Certificate of AnalysisSep 20, 2023 S275861
B2225306Certificate of AnalysisSep 20, 2023 S275861
B2225815Certificate of AnalysisSep 20, 2023 S275861
B2225825Certificate of AnalysisSep 20, 2023 S275861
B2225826Certificate of AnalysisSep 20, 2023 S275861
B2225829Certificate of AnalysisSep 20, 2023 S275861
B2225831Certificate of AnalysisSep 20, 2023 S275861
B2225843Certificate of AnalysisSep 20, 2023 S275861

Chemical and Physical Properties

SolubilitySoluble in DMSO

Related Documents

References

1. Liu H et al..  (2019)  Neutrophil elastase contributes to the pathological vascular permeability characteristic of diabetic retinopathy..  Diabetologia,  62  (12): (2365-2374).  [PMID:31612267]
2. Xia X et al..  (2022)  Neutrophil extracellular traps promote metastasis in gastric cancer patients with postoperative abdominal infectious complications..  Nat Commun,  13  (1017).  [PMID:35197446]
3. Zhang H et al..  (2021)  Tissue Factor-Enriched Neutrophil Extracellular Traps Promote Immunothrombosis and Disease Progression in Sepsis-Induced Lung Injury..  Front Cell Infect Microbiol,  11  (677902).  [PMID:34336711]

Solution Calculators