Determine the necessary mass, volume, or concentration for preparing a solution.
Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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SKU | Size | Availability | Price | Qty |
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S275861-5mg | 5mg | In stock | $49.90 | |
S275861-10mg | 10mg | In stock | $82.90 | |
S275861-25mg | 25mg | In stock | $186.90 | |
S275861-50mg | 50mg | In stock | $284.90 | |
S275861-100mg | 100mg | In stock | $414.90 | |
S275861-250mg | 250mg | In stock | $933.90 | |
S275861-1g | 1g | In stock | $3,361.90 | |
S275861-5g | 5g | In stock | $15,126.90 |
Neutrophil elastase inhibitor
Synonyms | LY544349 Sodium Hydrate | LY-544349 SODIUM HYDRATE | Tox21_112570 | (8R,9S,10R,13S,14S)-4-hydroxy-10,13-dimethyl-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthrene-3,17-quinone | CAS-201677-61-4 | EI-546 | Sivelestat (sodium salt hydrate) | A |
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Specifications & Purity | ≥98% |
Biochemical and Physiological Mechanisms | It is a competitive human neutrophil elastase (HNE) inhibitor (IC50 = 44 nm, Ki = 0.2 μ M)。 It also inhibited leukocyte elastase obtained from rabbits, rats, hamsters and mice (IC50 = 19 to 49 nm). But even at 100 μ At m, it also did not inhibit trypsin, |
Source | Synthetic |
Storage Temp | Store at -20°C |
Shipped In | Ice chest + Ice pads |
Note | Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details. |
Product Description | Store at Room Temperature. The product can be stored for up to 12 months. |
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Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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IUPAC Name | sodium;2-[[2-[[4-(2,2-dimethylpropanoyloxy)phenyl]sulfonylamino]benzoyl]amino]acetate;tetrahydrate |
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INCHI | InChI=1S/C20H22N2O7S.Na.4H2O/c1-20(2,3)19(26)29-13-8-10-14(11-9-13)30(27,28)22-16-7-5-4-6-15(16)18(25)21-12-17(23)24;;;;;/h4-11,22H,12H2,1-3H3,(H,21,25)(H,23,24);;4*1H2/q;+1;;;;/p-1 |
InChi Key | PLHREJBSQUSUCW-UHFFFAOYSA-M |
Canonical SMILES | CC(C)(C)C(=O)OC1=CC=C(C=C1)S(=O)(=O)NC2=CC=CC=C2C(=O)NCC(=O)[O-].O.O.O.O.[Na+] |
Isomeric SMILES | CC(C)(C)C(=O)OC1=CC=C(C=C1)S(=O)(=O)NC2=CC=CC=C2C(=O)NCC(=O)[O-].O.O.O.O.[Na+] |
PubChem CID | 23663985 |
Molecular Weight | 528.51 |
Enter Lot Number to search for COA:
Find and download the COA for your product by matching the lot number on the packaging.
Lot Number | Certificate Type | Date | Item |
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B2225300 | Certificate of Analysis | Sep 20, 2023 | S275861 |
B2225306 | Certificate of Analysis | Sep 20, 2023 | S275861 |
B2225815 | Certificate of Analysis | Sep 20, 2023 | S275861 |
B2225825 | Certificate of Analysis | Sep 20, 2023 | S275861 |
B2225826 | Certificate of Analysis | Sep 20, 2023 | S275861 |
B2225829 | Certificate of Analysis | Sep 20, 2023 | S275861 |
B2225831 | Certificate of Analysis | Sep 20, 2023 | S275861 |
B2225843 | Certificate of Analysis | Sep 20, 2023 | S275861 |
Solubility | Soluble in DMSO |
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1. Liu H et al.. (2019) Neutrophil elastase contributes to the pathological vascular permeability characteristic of diabetic retinopathy.. Diabetologia, 62 (12): (2365-2374). [PMID:31612267] |
2. Xia X et al.. (2022) Neutrophil extracellular traps promote metastasis in gastric cancer patients with postoperative abdominal infectious complications.. Nat Commun, 13 (1017). [PMID:35197446] |
3. Zhang H et al.. (2021) Tissue Factor-Enriched Neutrophil Extracellular Traps Promote Immunothrombosis and Disease Progression in Sepsis-Induced Lung Injury.. Front Cell Infect Microbiol, 11 (677902). [PMID:34336711] |