Basic Description

Synonyms	AC-36369 \| AKOS027254768 \| 2-phenyl-naphtho[2,3-d]oxazole-4,9-dione \| 2-PHENYLNAPHTHO[2,3-D]OXAZOLE-4,9-DIONE \| MFCD26960957 \| 2-phenyl-naphthoxazole-4,9-quinone \| A917582 \| GTPL12225 \| SJB2043 \| sjb2-043 \| 2-phenylbenzo[f][1,3]benzoxazole-4,9-dione \| CS-
Specifications & Purity	Moligand™, ≥98%
Biochemical and Physiological Mechanisms	IC50 Value: 0.544 uM (USP1) SJB2-043 is one of analogs/derivatives of C527, which is a novel and potent USP1 (ubiquitin-specific protease 1) inhibitor. Cells were treated with SJB2-043 for 24 hrs and cell extracts were incubated with HA-Ub-VS, followed b
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Grade	Moligand™
Action Type	INHIBITOR
Mechanism of action	Inhibitor of ubiquitin specific peptidase 1

Associated Targets(Human)

USP1 Tchem Ubiquitin carboxyl-terminal hydrolase 1 (1 Activities)

Discover Target: USP1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

HepG2 (196354 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

USP1 Tchem Ubiquitin carboxyl-terminal hydrolase 1 (22556 Activities)

Discover Target: USP1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

OTUB1 Tbio Ubiquitin thioesterase OTUB1 (157 Activities)

Discover Target: OTUB1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Associated Targets(non-human)

rep Replicase polyprotein 1ab (378 Activities)

Discover Target: rep

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

SARS-CoV-2 (38078 Activities)

Explore this target

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

IUPAC Name	2-phenylbenzo[f][1,3]benzoxazole-4,9-dione
INCHI	InChI=1S/C17H9NO3/c19-14-11-8-4-5-9-12(11)15(20)16-13(14)18-17(21-16)10-6-2-1-3-7-10/h1-9H
InChi Key	CMYQQADDUUDCCA-UHFFFAOYSA-N
Canonical SMILES	C1=CC=C(C=C1)C2=NC3=C(O2)C(=O)C4=CC=CC=C4C3=O
Isomeric SMILES	C1=CC=C(C=C1)C2=NC3=C(O2)C(=O)C4=CC=CC=C4C3=O
PubChem CID	509070
Molecular Weight	275.26

Database links

ChEMBL Ligand	CHEMBL3407552
PubChem CID	509070
CAS Registry No.	63388-44-3

Certificates

Certificate of Analysis(COA)

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6 results found

Lot Number	Certificate Type	Date	Item
C2210188	Certificate of Analysis	Dec 20, 2023	S126106
C2210190	Certificate of Analysis	Dec 20, 2023	S126106
C2210191	Certificate of Analysis	Dec 20, 2023	S126106
C2210192	Certificate of Analysis	Dec 20, 2023	S126106
C2210193	Certificate of Analysis	Dec 20, 2023	S126106
C2210663	Certificate of Analysis	Dec 20, 2023	S126106

Chemical and Physical Properties

Solubility	insoluble in H2O; insoluble in EtOH; ≥6.68 mg/mL in DMSO

References

1. Mistry H, Hsieh G, Buhrlage SJ, Huang M, Park E, Cuny GD, Galinsky I, Stone RM, Gray NS, D'Andrea AD et al.. (2013) Small-molecule inhibitors of USP1 target ID1 degradation in leukemic cells.. Mol Cancer Ther, 12 (12): (2651-62). [PMID:24130053]
2. Tan L, Shan H, Han C, Zhang Z, Shen J, Zhang X, Xiang H, Lu K, Qi C, Li Y et al.. (2022) Discovery of Potent OTUB1/USP8 Dual Inhibitors Targeting Proteostasis in Non-Small-Cell Lung Cancer.. J Med Chem, 71 (13): (1755-70). [PMID:36221183]

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SKU	Size	Availability	Price
S126106-1mg	1mg	In stock	$130.90
S126106-5mg	5mg	In stock	$276.90
S126106-10mg	10mg	In stock	$420.90
S126106-25mg	25mg	In stock	$947.90
S126106-50mg	50mg	In stock	$997.90
S126106-100mg	100mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$1,662.90

SJB2-043 - 98%, high purity , CAS No.63388-44-3, Inhibitor of ubiquitin specific peptidase 1