IC50 Value: 0.544 uM (USP1)
SJB2-043 is one of analogs/derivatives of C527, which is a novel and potent USP1 (ubiquitin-specific protease 1) inhibitor.
Cells were treated with SJB2-043 for 24 hrs and cell extracts were incubated with HA-Ub-VS, followed b
1.Mistry H, Hsieh G, Buhrlage SJ, Huang M, Park E, Cuny GD, Galinsky I, Stone RM, Gray NS, D'Andrea AD et al.. (2013) Small-molecule inhibitors of USP1 target ID1 degradation in leukemic cells.. Mol Cancer Ther, 12 (12):(2651-62). [PMID:24130053]
2.Tan L, Shan H, Han C, Zhang Z, Shen J, Zhang X, Xiang H, Lu K, Qi C, Li Y et al.. (2022) Discovery of Potent OTUB1/USP8 Dual Inhibitors Targeting Proteostasis in Non-Small-Cell Lung Cancer.. J Med Chem, 129 (3):(589-97). [PMID:36221183]
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C2210188