Basic Description

Synonyms	sjb2-043 \| 63388-44-3 \| 2-PHENYLNAPHTHO[2,3-D]OXAZOLE-4,9-DIONE \| 2-phenylbenzo[f][1,3]benzoxazole-4,9-dione \| CHEMBL3407552 \| SJB2 043 \| 2-Phenyl-naphth[2,3-d]oxazole-4,9-dione \| 2-phenyl-naphtho[2,3-d]oxazole-4,9-dione \| SCHEMBL7808226 \| GTPL12225 \| DTXSID40333501 \| SJB2043 \|
Specifications & Purity	Moligand™, 2mM in DMSO
Biochemical and Physiological Mechanisms	IC50 Value: 0.544 uM (USP1) SJB2-043 is one of analogs/derivatives of C527, which is a novel and potent USP1 (ubiquitin-specific protease 1) inhibitor. Cells were treated with SJB2-043 for 24 hrs and cell extracts were incubated with HA-Ub-VS, followed b
Storage Temp	Store at -80°C
Shipped In	Ice chest + Ice pads
Grade	Moligand™

Associated Targets(Human)

USP1 Tchem Ubiquitin carboxyl-terminal hydrolase 1 (1 Activities)

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

HepG2 (196354 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

USP1 Tchem Ubiquitin carboxyl-terminal hydrolase 1 (22556 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

OTUB1 Tbio Ubiquitin thioesterase OTUB1 (157 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

rep Replicase polyprotein 1ab (378 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

SARS-CoV-2 (38078 Activities)

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

IUPAC Name	2-phenylbenzo[f][1,3]benzoxazole-4,9-dione
INCHI	InChI=1S/C17H9NO3/c19-14-11-8-4-5-9-12(11)15(20)16-13(14)18-17(21-16)10-6-2-1-3-7-10/h1-9H
InChi Key	CMYQQADDUUDCCA-UHFFFAOYSA-N
Canonical SMILES	C1=CC=C(C=C1)C2=NC3=C(O2)C(=O)C4=CC=CC=C4C3=O
Isomeric SMILES	C1=CC=C(C=C1)C2=NC3=C(O2)C(=O)C4=CC=CC=C4C3=O
PubChem CID	509070
Molecular Weight	275.26

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