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SKU | Size | Availability | Price | Qty |
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S650665-2mg | 2mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $66.90 | |
S650665-5mg | 5mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $286.90 | |
S650665-10mg | 10mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $432.90 | |
S650665-50mg | 50mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $1,026.90 | |
S650665-100mg | 100mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $1,596.90 |
Specifications & Purity | ≥99% |
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Biochemical and Physiological Mechanisms | SJB3-019A is a potent and novel USP1 inhibitor, 5 times more potent than SJB2-043 in promoting ID1 degradation and cytoxicity in K562 cells with IC 50 of 0.0781 μM. |
Storage Temp | Store at -20°C |
Shipped In | Ice chest + Ice pads |
Product Description | SJB3-019A is a potent and novel USP1 inhibitor, 5 times more potent than SJB2-043 in promoting ID1 degradation and cytoxicity in K562 cells with IC 50 of 0.0781 μM. In Vitro SJB3-019A (IC 50 =0.0781 μM) is 5 times more potent than SJB2-043 in promoting ID1 degradation and cytoxicity in K562 cells. SJB3-019A increases the levels of Ub-FANCD2 and Ub-PCNA, and decreases the HR activity. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:IC50: 78.1 nM (ID1) |
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IUPAC Name | 2-pyridin-3-ylbenzo[f][1,3]benzoxazole-4,9-dione |
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INCHI | InChI=1S/C16H8N2O3/c19-13-10-5-1-2-6-11(10)14(20)15-12(13)18-16(21-15)9-4-3-7-17-8-9/h1-8H |
InChi Key | DOYPPVCQHGJUBC-UHFFFAOYSA-N |
Canonical SMILES | C1=CC=C2C(=C1)C(=O)C3=C(C2=O)OC(=N3)C4=CN=CC=C4 |
Isomeric SMILES | C1=CC=C2C(=C1)C(=O)C3=C(C2=O)OC(=N3)C4=CN=CC=C4 |
PubChem CID | 78358325 |
Molecular Weight | 276.25 |
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Solubility | DMSO : 10 mg/mL (36.20 mM; Need ultrasonic) |
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