Determine the necessary mass, volume, or concentration for preparing a solution.
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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S275256-5mg | 5mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $71.90 | |
S275256-10mg | 10mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $128.90 | |
S275256-50mg | 50mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $522.90 |
Highly potent GABA B agonist
Synonyms | 3-Apmpa | AKOS005468710 | Lopac0_000098 | NCGC00015015-04 | Phosphinic acid, (3-(aminopropyl)methyl)- | Phosphinic acid, P-(3-aminopropyl)-P-methyl- | Biomol-NT_000257 | 3-aminopropylmethylphosphinic acid | 3-aminopropyl-methylphosphinic acid | 3-aminopro |
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Specifications & Purity | Moligand™, ≥98% |
Biochemical and Physiological Mechanisms | Highly potent GABA B agonist, 10-fold more potent than Baclofen . (EC 50 values for depression of striatal synaptic potentials are 920 nM and 1.25 μM for SKF97541 and baclofen, |
Storage Temp | Room temperature,Desiccated |
Shipped In | Normal |
Grade | Moligand™ |
Action Type | AGONIST |
Mechanism of action | Agonist of GABA B receptor |
Note | Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details. |
Product Description | Store at Room Temperature. Store under desiccating conditions. The product can be stored for up to 12 months. |
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Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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IUPAC Name | 3-aminopropyl(methyl)phosphinic acid |
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INCHI | InChI=1S/C4H12NO2P/c1-8(6,7)4-2-3-5/h2-5H2,1H3,(H,6,7) |
InChi Key | NHVRIDDXGZPJTJ-UHFFFAOYSA-N |
Canonical SMILES | CP(=O)(CCCN)O |
Isomeric SMILES | CP(=O)(CCCN)O |
PubChem CID | 5230 |
Molecular Weight | 137.119 |
PubChem CID | 5230 |
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ChEMBL Ligand | CHEMBL112710 |
BindingDB Ligand | 24185 |
CAS Registry No. | 127729-35-5 |
Wikipedia | SKF-97,541 |
RCSB PDB Ligand | QD7 |
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Solubility | Soluble in water to 100 mM |
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Pictogram(s) | GHS06, GHS07 |
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Signal | Danger |
Hazard Statements | H319:Causes serious eye irritation H301:Toxic if swallowed |
Precautionary Statements | P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P270:Do not eat, drink or smoke when using this product. P330:Rinse mouth. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P301+P316:IF SWALLOWED: Get emergency medical help immediately. P337+P317:If eye irritation persists: Get medical help. |