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SKF38393 HCl - 98%, high purity , CAS No.62717-42-4
D 1 -like dopamine receptor agonist
Basic Description Synonyms (y)-SKF-38393 hydrochloride | HY-12520A | ( inverted question mark)-1-Phenyl-2,3,4,5-tetrahydro-(1H)-3-benzazepine-7,8-diol hydrochloride | WIV5R2G7VP | CS-5354 | SKF38393 HCl | SKF-38393 HCl | Y10638 | EU-0100436 | SKF-38393A | (+/-)-Skf-38393 hydrochlor Specifications & Purity ≥98% Biochemical and Physiological Mechanisms D 1 -like dopamine receptor agonist. pK i values are 9 (D 1 ), 6.8 (D 2 ), 5.3 (D 3 ), 6.0 (D 4 ) and 9.3 (D 5 ). K i values are 151 and 2364 nM for D 1 -like and D 2 -like dopamine receptors, respectively. Centrally active upon systemic administration. Storage Temp Store at -20°C Shipped In Ice chest + Ice pads Note Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Associated Targets(Human) Associated Targets(non-human) Mechanisms of Action Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References
Names and Identifiers IUPAC Name 5-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine-7,8-diol;hydrochloride INCHI InChI=1S/C16H17NO2.ClH/c18-15-8-12-6-7-17-10-14(13(12)9-16(15)19)11-4-2-1-3-5-11;/h1-5,8-9,14,17-19H,6-7,10H2;1H InChi Key YEWHJCLOUYPAOH-UHFFFAOYSA-N Canonical SMILES C1CNCC(C2=CC(=C(C=C21)O)O)C3=CC=CC=C3.Cl Isomeric SMILES C1CNCC(C2=CC(=C(C=C21)O)O)C3=CC=CC=C3.Cl PubChem CID 147514 Molecular Weight 291.78
Chemical and Physical Properties Sensitivity Moisture sensitive.
Safety and Hazards(GHS) Pictogram(s) GHS07 Signal Warning Hazard Statements H315: Causes skin irritation
H319: Causes serious eye irritation
H335: May cause respiratory irritation
Precautionary Statements P261: Avoid breathing dust/fume/gas/mist/vapors/spray.
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352: IF ON SKIN: wash with plenty of water.
P321: Specific treatment (see ... on this label).
P405: Store locked up.
P501: Dispose of contents/container to ...
P264: Wash hands [and …] thoroughly after handling.
P271: Use only outdoors or in a well-ventilated area.
P304+P340: IF INHALED: Remove person to fresh air and keep comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P362+P364: Take off contaminated clothing and wash it before reuse.
P264+P265: Wash hands [and …] thoroughly after handling. Do not touch eyes.
P337+P317: If eye irritation persists: Get medical help.
P332+P317: If skin irritation occurs: Get medical help.
P319: Get medical help if you feel unwell.
References 1. Xie CL et al.. (2016) Inhibition of Glycogen Synthase Kinase-3ß (GSK-3ß) as potent therapeutic strategy to ameliorates L-dopa-induced dyskinesia in 6-OHDA parkinsonian rats.. Sci Rep, 6 (23527). [PMID:26997328 ]
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