SKI II - ≥98%, high purity , CAS No.312636-16-1, Inhibitor of delta 4-desaturase; sphingolipid 1;Inhibitor of sphingosine kinase 1;Inhibitor of sphingosine kinase 2

Item Number

S129855

• Synonyms: SKI II | 312636-16-1 | 4-[[4-(4-Chlorophenyl)-2-thiazolyl]amino]phenol | SphK-I2 | SKI-II | 4-[[4-(4-chlorophenyl)-1,3-thiazol-2-yl]amino]phenol | Sphingosine Kinase Inhibitor 2 | 4-(4-(4-chlorophenyl)thiazol-2-ylamino)phenol | Sphingosine Kinase Inhibitor | 4-{[4-(4-chlor
• Specifications & Purity: Moligand™, ≥98%
• Biochemical and Physiological Mechanisms: SKI II is a selective non-lipid inhibitor of SphK(sphingosine kinase) (IC50 = 0.5 μM); does not act at ATP-binding site. SKI II displays no inhibition of ERK2, PI 3-kinase, or PKCα at concentrations up to 60 μM. Reduces levels of sphingosine-1-phosphate i
• Storage Temp: Store at -20°C
• Shipped In: Ice chest + Ice pads
• Grade: Moligand™
• Action Type: INHIBITOR
• Mechanism of action: Inhibitor of delta 4-desaturase; sphingolipid 1;Inhibitor of sphingosine kinase 1;Inhibitor of sphingosine kinase 2
• Note: Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Product Description

SKI-II is a synthetic inhibitor of sphingosine kinase (SK) activity with IC50 of 78 μM for SK1 and 45 μM for SK2.
Human cisplatin-resistant gastric cancer cell line was treated with SKI-II to study the mechanism of reversion of multidrug resistance.