SKI II - 10mM in DMSO, high purity , CAS No.312636-16-1

Item Number

S423221

• Synonyms: SKI II | 312636-16-1 | 4-[[4-(4-Chlorophenyl)-2-thiazolyl]amino]phenol | SphK-I2 | SKI-II | 4-[[4-(4-chlorophenyl)-1,3-thiazol-2-yl]amino]phenol | Sphingosine Kinase Inhibitor 2 | 4-(4-(4-chlorophenyl)thiazol-2-ylamino)phenol | Sphingosine Kinase Inhibitor | 4-{[4-(4-chlor
• Specifications & Purity: Moligand™, 10mM in DMSO
• Biochemical and Physiological Mechanisms: SKI II is a selective non-lipid inhibitor of SphK(sphingosine kinase) (IC50 = 0.5 μM); does not act at ATP-binding site. SKI II displays no inhibition of ERK2, PI 3-kinase, or PKCα at concentrations up to 60 μM. Reduces levels of sphingosine-1-phosphate i
• Storage Temp: Store at -80°C
• Shipped In: Ice chest + Ice pads
• Grade: Moligand™

Product Description

SKI-II is a synthetic inhibitor of sphingosine kinase (SK) activity with IC50 of 78 μM for SK1 and 45 μM for SK2.
Human cisplatin-resistant gastric cancer cell line was treated with SKI-II to study the mechanism of reversion of multidrug resistance.