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SLM 6031434 hydrochloride - ≥98%(HPLC), high purity , CAS No.1897379-34-8
Selective sphingosine kinase 2 (Sphk2) inhibitor
Basic Description Synonyms (2S)-2-[3-[4-(Octyloxy)-3-(trifluoromethyl)phenyl]-1,2,4-oxadiazol-5-yl]-1-pyrrolidinecarboximidamide hydrochloride Specifications & Purity ≥98%(HPLC) Biochemical and Physiological Mechanisms Sphk2 inhibitor (Ki= 0.4 μM for mouse Sphk2). Exhibits 40-fold selectivity for Sphk2 over Sphk1. Decreases levels of sphingosine-1-phosphate (S1P) in U937 cellsin vitroand increases blood levels of S1P in wild-type mice. Storage Temp Store at -20°C Shipped In Ice chest + Ice pads
Associated Targets(Human) Names and Identifiers IUPAC Name (2S)-2-[3-[4-octoxy-3-(trifluoromethyl)phenyl]-1,2,4-oxadiazol-5-yl]pyrrolidine-1-carboximidamide;hydrochloride INCHI InChI=1S/C22H30F3N5O2.ClH/c1-2-3-4-5-6-7-13-31-18-11-10-15(14-16(18)22(23,24)25)19-28-20(32-29-19)17-9-8-12-30(17)21(26)27;/h10-11,14,17H,2-9,12-13H2,1H3,(H3,26,27);1H/t17-;/m0./s1 InChi Key YIGAQKBPLMSWOD-LMOVPXPDSA-N Canonical SMILES CCCCCCCCOC1=C(C=C(C=C1)C2=NOC(=N2)C3CCCN3C(=N)N)C(F)(F)F.Cl Isomeric SMILES CCCCCCCCOC1=C(C=C(C=C1)C2=NOC(=N2)[C@@H]3CCCN3C(=N)N)C(F)(F)F.Cl PubChem CID 134812833 Molecular Weight 489.96
Chemical and Physical Properties Solubility Solvent:water, Max Conc. mg/mL: 9.8, Max Conc. mM: 20; Solvent:DMSO, Max Conc. mg/mL: 49, Max Conc. mM: 100
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