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Inhibitors of apoptosis (IAP) protein family
SM-122 , CAS No.S613627, Inhibitor of baculoviral IAP repeat containing 2;Inhibitor of baculoviral IAP repeat containing 3;Inhibitor of X-linked inhibitor of apoptosis

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SM-122 , CAS No.S613627, Inhibitor of baculoviral IAP repeat containing 2;Inhibitor of baculoviral IAP repeat containing 3;Inhibitor of X-linked inhibitor of apoptosis

Moligand™

PubChem CID: 24754886

Item Number

S613627

Grouped product items
SKU	Size	Availability	Price	Qty
S613627-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,072.90
S613627-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$3,216.90

View related series

baculoviral IAP repeat containing 2 Inhibitor baculoviral IAP repeat containing 3 Inhibitor X-linked inhibitor of apoptosis Inhibitor

Basic Description

Synonyms	compound 1;Smac peptide mimetic 20
Grade	Moligand™
Action Type	INHIBITOR
Mechanism of action	Inhibitor of baculoviral IAP repeat containing 2;Inhibitor of baculoviral IAP repeat containing 3;Inhibitor of X-linked inhibitor of apoptosis

Associated Targets

BIRC8 Tchem Baculoviral IAP repeat-containing protein 8 1 Activities

Discover Target: BIRC8

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

BIRC2 Tchem Baculoviral IAP repeat-containing protein 2 11 Activities

Discover Target: BIRC2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

BIRC3 Tchem Baculoviral IAP repeat-containing protein 3 8 Activities

Discover Target: BIRC3

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

XIAP Tchem E3 ubiquitin-protein ligase XIAP 15 Activities

Discover Target: XIAP

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Names and Identifiers

IUPAC Name	(3S,6S,10aS)-N-benzhydryl-6-[[(2S)-2-(methylamino)propanoyl]amino]-5-oxo-2,3,6,7,8,9,10,10a-octahydro-1H-pyrrolo[1,2-a]azocine-3-carboxamide
INCHI	InChI=1S/C28H36N4O3/c1-19(29-2)26(33)30-23-16-10-9-15-22-17-18-24(32(22)28(23)35)27(34)31-25(20-11-5-3-6-12-20)21-13-7-4-8-14-21/h3-8,11-14,19,22-25,29H,9-10,15-18H2,1-2H3,(H,30,33)(H,31,34)/t19-,22-,23-,24-/m0/s1
InChi Key	XBTLZUHJBOBKRG-HCUBDLJJSA-N
Canonical SMILES	CN[C@H](C(=O)N[C@H]1CCCC[C@@H]2N(C1=O)[C@@H](CC2)C(=O)NC(c1ccccc1)c1ccccc1)C
Isomeric SMILES	C[C@@H](C(=O)N[C@H]1CCCC[C@H]2CC[C@H](N2C1=O)C(=O)NC(C3=CC=CC=C3)C4=CC=CC=C4)NC
PubChem CID	24754886

Database links

ChEMBL Ligand	CHEMBL481422
PubChem CID	24754886

Certificates

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References

1. Peng Y, Sun H, Nikolovska-Coleska Z, Qiu S, Yang CY, Lu J, Cai Q, Yi H, Kang S, Yang D et al.. (2008) Potent, orally bioavailable diazabicyclic small-molecule mimetics of second mitochondria-derived activator of caspases.. J Med Chem, 51 (24): (8158-62). [PMID:19049347]

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