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SM-21 maleate - ≥98%, high purity , CAS No.155058-71-2, Antagonist of σ2
Basic Description Specifications & Purity Moligand™, ≥98% Storage Temp Room temperature Shipped In Normal Grade Moligand™ Action Type ANTAGONIST Mechanism of action Antagonist of σ2 Product Description SM-21 maleate is a potent and selective σ receptor (σ2) antagonist with central effects following systemic administration. SM-21 maleate increases release of acetylcholine at central muscarinic synapses. SM-21 maleate is a potent analgesic (efficacy comparable to morphine) and nootropic agent.
Product Properties Ki Data Muscarinic acetylcholine receptor: Ki= 174 nM (rat)
Associated Targets(Human) Associated Targets(non-human) Names and Identifiers IUPAC Name (8-methyl-8-azabicyclo[3.2.1]octan-3-yl) 2-(4-chlorophenoxy)butanoate INCHI InChI=1S/C18H24ClNO3/c1-3-17(22-15-8-4-12(19)5-9-15)18(21)23-16-10-13-6-7-14(11-16)20(13)2/h4-5,8-9,13-14,16-17H,3,6-7,10-11H2,1-2H3 InChi Key WTPAXDRULIZRDJ-UHFFFAOYSA-N Canonical SMILES CCC(C(=O)OC1CC2CCC(C1)N2C)OC3=CC=C(C=C3)Cl Isomeric SMILES CCC(C(=O)OC1CC2CCC(C1)N2C)OC3=CC=C(C=C3)Cl PubChem CID 4679312 Molecular Weight 453.92
Chemical and Physical Properties Solubility Soluble in water (25 mM). Refractive Index n20D~1.56 (Predicted) Melt Point(°C) 94-99° C
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