Basic Description

Specifications & Purity	≥99%(HPLC)
Biochemical and Physiological Mechanisms	Inhibitor of Smoothened (Smo) signaling via a unique mechanism. Inhibits Shh-induced accumulation of Smo::EGFP fusion protein in the primary cilium (IC50= 1.1μM). Inhibits both wild-type Smo and an oncogenic form (SmoM2) with similar efficacy.
Storage Temp	Store at -20°C,Desiccated
Shipped In	Ice chest + Ice pads

Associated Targets(Human)

GLP1R Tclin Glucagon-like peptide 1 receptor (111429 Activities)

Discover Target: GLP1R

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

POLI Tchem DNA polymerase iota (116820 Activities)

Discover Target: POLI

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

APEX1 Tchem DNA-(apurinic or apyrimidinic site) lyase (38016 Activities)

Discover Target: APEX1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

EHMT2 Tchem Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 (93046 Activities)

Discover Target: EHMT2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

TDP1 Tchem Tyrosyl-DNA phosphodiesterase 1 (345557 Activities)

Discover Target: TDP1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Associated Targets(non-human)

Plasmodium falciparum (966862 Activities)

Explore this target

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

IUPAC Name	N-(4-bromophenyl)-3-(3,5-dimethylpiperidin-1-yl)propanamide;hydrochloride
INCHI	InChI=1S/C16H23BrN2O.ClH/c1-12-9-13(2)11-19(10-12)8-7-16(20)18-15-5-3-14(17)4-6-15;/h3-6,12-13H,7-11H2,1-2H3,(H,18,20);1H
InChi Key	XQESCHFXROUCOQ-UHFFFAOYSA-N
Canonical SMILES	CC1CC(CN(C1)CCC(=O)NC2=CC=C(C=C2)Br)C.Cl
Isomeric SMILES	CC1CC(CN(C1)CCC(=O)NC2=CC=C(C=C2)Br)C.Cl
PubChem CID	2900213
UN Number	3077
Packing Group	III
Molecular Weight	375.73

Certificates

Certificate of Analysis(COA)

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5 results found

Lot Number	Certificate Type	Date	Item
K2225118	Certificate of Analysis	Aug 25, 2022	S288275
K2225121	Certificate of Analysis	Aug 25, 2022	S288275
K2225134	Certificate of Analysis	Aug 25, 2022	S288275
K2225135	Certificate of Analysis	Aug 25, 2022	S288275
K2225329	Certificate of Analysis	Aug 25, 2022	S288275

Chemical and Physical Properties

Solubility	Solvent:water, Max Conc. mg/mL: 7.51, Max Conc. mM: 20; Solvent:DMSO, Max Conc. mg/mL: 37.57, Max Conc. mM: 100

Safety and Hazards(GHS)

Pictogram(s)	GHS08, GHS09, GHS07
Signal	Danger
Hazard Statements	H302:Harmful if swallowed H410:Very toxic to aquatic life with long lasting effects H372:Causes damage to organs through prolonged or repeated exposure H361:Suspected of damaging fertility or the unborn child
Precautionary Statements	P280:Wear protective gloves/protective clothing/eye protection/face protection. P312:Call a POISON CENTER or doctor/... if you feel unwell. P264:Wash hands [and …] thoroughly after handling. P201:Obtain special instructions before use. P301+P330+P331:IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
Class	9
RIDADR	UN30779/PGIII

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SKU	Size	Availability	Price
S288275-5mg	5mg	In stock	$68.90
S288275-10mg	10mg	In stock	$107.90
S288275-25mg	25mg	In stock	$216.90
S288275-50mg	50mg	In stock	$375.90
S288275-100mg	100mg	In stock	$642.90

SMANT hydrochloride - ≥99%(HPLC), high purity , CAS No.1177600-74-6