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SMC2 Antibody - Primary antibody, specific to SMC2, Rabbit IgG

Carrier Free

Validated

ExactAb™

0.5 mg/mL

Features and benefits

Short Overview:
pAb; Rabbit anti Human SMC2 Antibody; WB; Unconjugated
Species reactivity(Reacts with): Human
Isotype: Rabbit IgG

Application:

Item Number

Ab128309

Grouped product items
SKU	Size	Availability	Price
Ab128309-10μl	10μl	In stock	$69.90
Ab128309-50μl	50μl	In stock	$199.90
Ab128309-100μl	100μl	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$309.90
Ab128309-1ml	1ml	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$2,899.90

pAb; Rabbit anti Human SMC2 Antibody; WB; Unconjugated

View related series

Click to view target information: SMC2

Accession#:O95347 Gene ID:10592

Basic Description

Product Name	SMC2 Antibody - Primary antibody, specific to SMC2, Rabbit IgG
Synonyms	Chromosome-associated protein E \| hCAP-E \| SMC protein 2 \| SMC-2 \| XCAP-E homolog \| CAP E antibody \| CAPE antibody \| Chromosome associated protein E antibody \| Chromosome-associated protein E antibody \| FLJ10093 antibody \| hCAP E antibody \| hCAP-E antibod
Specifications & Purity	ExactAb™, Validated, Carrier Free, 0.5 mg/mL
Host species	Rabbit
Specificity	SMC2
Immunogen	A synthetic peptide derived from human SMC2 (AA 1165-1197)
Positive Control	WB: Jurkat, A172, A549 lysates
Conjugation	Unconjugated
Grade	Carrier Free, ExactAb™, Validated
Product Description	Rabbit anti Human SMC2 Antibody, Polyclonal, could be used for WB and so on. Application: WB: 1/500-1/1000 Protein Function Central component of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases.

Product Properties

Isotype	Rabbit IgG
SDS-PAGE	150 kDa
Purification Method	Protein A purified
Form	Liquid
Concentration	0.5 mg/mL
Storage Temp	Store at -20°C,Avoid repeated freezing and thawing
Shipped In	Ice chest + Ice pads
Stability And Storage	Store at 4°C short term (1-2 weeks). Store at -20°C long term (24 months). Upon delivery aliquot. Avoid freeze/thaw cycle.

Associated Targets(Human)

SMC2 Tchem Structural maintenance of chromosomes protein 2 (0 Activities)

Discover Target: SMC2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

SMC2 Tchem Structural maintenance of chromosomes protein 2 (241 Activities)

Discover Target: SMC2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Application

Dilution info

1/500-1/1000

Certificates

Certificate of Analysis(COA)

Enter Lot Number to search for COA:

Find and download the COA for your product by matching the lot number on the packaging.

2 results found

Lot Number	Certificate Type	Date	Item
ZJ24F0505946	Certificate of Analysis	May 22, 2024	Ab128309
ZJ24F0505947	Certificate of Analysis	May 22, 2024	Ab128309

References

1. Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M. (2009) Lysine acetylation targets protein complexes and co-regulates major cellular functions.. Science, 325 (5942): (834-40). [PMID:19608861]
2. Klaeger S, Heinzlmeir S and Wilhelm M et al. (2017) The target landscape of clinical kinase drugs.. Science, 358 (6367): [PMID:29191878]
3. Schmiesing, J A JA and 5 more authors.. (1998) Identification of two distinct human SMC protein complexes involved in mitotic chromosome dynamics.. Proceedings of the National Academy of Sciences of the United States of America, (27): [PMID:9789013]
4. Schmiesing, J A JA, Gregson, H C HC, Zhou, S S and Yokomori, K K.. (2000) A human condensin complex containing hCAP-C-hCAP-E and CNAP1, a homolog of Xenopus XCAP-D2, colocalizes with phosphorylated histone H3 during the early stage of mitotic chromosome condensation.. Molecular and cellular biology, [PMID:10958694]
5. Kimura, K K, Cuvier, O O and Hirano, T T.. (2001) Chromosome condensation by a human condensin complex in Xenopus egg extracts.. The Journal of biological chemistry, (23): [PMID:11136719]
6. Cobbe, Neville N and Heck, Margarete M S MM.. (2004) The evolution of SMC proteins: phylogenetic analysis and structural implications.. Molecular biology and evolution, [PMID:14660695]
7. Humphray, S J SJ and 147 more authors.. (2004) DNA sequence and analysis of human chromosome 9.. Nature, (27): [PMID:15164053]
8. Floyd, Scott R SR and 23 more authors.. (2013) The bromodomain protein Brd4 insulates chromatin from DNA damage signalling.. Nature, (13): [PMID:23728299]

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