SMC2 Antibody - Primary antibody, specific to SMC2, Rabbit IgG
Synonyms
Chromosome-associated protein E|hCAP-E|SMC protein 2|SMC-2|XCAP-E homolog
Specifications & Purity
ExactAb™, Validated, Carrier Free, 0.5 mg/mL
Host species
Rabbit
Specificity
SMC2
Immunogen
A synthetic peptide derived from human SMC2 (AA 1165-1197)
Positive Control
WB: Jurkat, A172, A549 lysates
Conjugation
Unconjugated
Grade
Carrier Free, ExactAb™, Validated
Product Description
Rabbit anti Human SMC2 Antibody, Polyclonal, could be used for WB and so on. Application: WB: 1/500-1/1000 Protein Function Central component of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases.
Product Properties
Isotype
Rabbit IgG
SDS-PAGE
150 kDa
Purification Method
Protein A purified
Form
Liquid
Concentration
0.5 mg/mL
Storage Temp
Store at -20°C,Avoid repeated freezing and thawing
Shipped In
Ice chest + Ice pads
Stability And Storage
Store at 4°C short term (1-2 weeks). Store at -20°C long term (24 months). Upon delivery aliquot. Avoid freeze/thaw cycle.
Associated Targets
SMC2Tchem Structural maintenance of chromosomes protein 2 0 Activities
1.Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M. (2009) Lysine acetylation targets protein complexes and co-regulates major cellular functions.. Science, 325 (5942):(834-40). [PMID:19608861]
2.Klaeger S, Heinzlmeir S and Wilhelm M et al. (2017) The target landscape of clinical kinase drugs.. Science, 358 (6367):[PMID:29191878]
3.Schmiesing, J A JA and 5 more authors.. (1998) Identification of two distinct human SMC protein complexes involved in mitotic chromosome dynamics.. Proceedings of the National Academy of Sciences of the United States of America, (27):[PMID:9789013]
4.Schmiesing, J A JA, Gregson, H C HC, Zhou, S S and Yokomori, K K.. (2000) A human condensin complex containing hCAP-C-hCAP-E and CNAP1, a homolog of Xenopus XCAP-D2, colocalizes with phosphorylated histone H3 during the early stage of mitotic chromosome condensation.. Molecular and cellular biology, [PMID:10958694]
5.Kimura, K K, Cuvier, O O and Hirano, T T.. (2001) Chromosome condensation by a human condensin complex in Xenopus egg extracts.. The Journal of biological chemistry, (23):[PMID:11136719]
6.Cobbe, Neville N and Heck, Margarete M S MM.. (2004) The evolution of SMC proteins: phylogenetic analysis and structural implications.. Molecular biology and evolution, [PMID:14660695]
7.Humphray, S J SJ and 147 more authors.. (2004) DNA sequence and analysis of human chromosome 9.. Nature, (27):[PMID:15164053]
8.Floyd, Scott R SR and 23 more authors.. (2013) The bromodomain protein Brd4 insulates chromatin from DNA damage signalling.. Nature, (13):[PMID:23728299]
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